Search Results - "YAMASHINA, Shunhei"

Nonalcoholic fatty liver disease and alcohol-related liver disease: From clinical aspects to pathophysiological insights by Ikejima, Kenichi, Kon, Kazuyoshi, Yamashina, Shunhei

“…Two major causes of steatohepatitis are alcohol and metabolic syndrome. Although the underlying causes of alcoholrelated liver disease (ALD) and nonalcoholic…”
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Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease by Fukuo, Yuka, Yamashina, Shunhei, Sonoue, Hiroshi, Arakawa, Atsushi, Nakadera, Eisuke, Aoyama, Tomonori, Uchiyama, Akira, Kon, Kazuyoshi, Ikejima, Kenichi, Watanabe, Sumio

“…Aim Recent evidences indicate that hepatic steatosis suppresses autophagic proteolysis. The present study evaluated the correlation between autophagic function…”
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Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression by Inami, Yoshihiro, Yamashina, Shunhei, Izumi, Kousuke, Ueno, Takashi, Tanida, Isei, Ikejima, Kenichi, Watanabe, Sumio

“…► Acidification of autophagosome was blunted in steatotic hepatocytes. ► Hepatic steatosis did not disturb fusion of isolated autophagosome and lysosome. ►…”
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Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress by Kusama, Hiromi, Kon, Kazuyoshi, Ikejima, Kenichi, Arai, Kumiko, Aoyama, Tomonori, Uchiyama, Akira, Yamashina, Shunhei, Watanabe, Sumio

“…Background Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis. Previous studies have indicated that…”
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Loss of autophagy promotes murine acetaminophen hepatotoxicity by Igusa, Yuki, Yamashina, Shunhei, Izumi, Kousuke, Inami, Yoshihiro, Fukada, Hiroo, Komatsu, Masaaki, Tanaka, Keiji, Ikejima, Kenichi, Watanabe, Sumio

“…Background Previous reports indicate that mitochondrial dysfunction is essential for the development of liver injury due to acetaminophen. On the other hand,…”
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Formation of p62‐positive inclusion body is associated with macrophage polarization in non‐alcoholic fatty liver disease by Fukushima, Hirofumi, Yamashina, Shunhei, Arakawa, Atsushi, Taniguchi, Gentaro, Aoyama, Tomonori, Uchiyama, Akira, Kon, Kazuyoshi, Ikejima, Kenichi, Watanabe, Sumio

“…Aim Hepatic inclusion composed of autophagy‐specific substrate p62 is one of the histological features of non‐alcoholic fatty liver disease (NAFLD) and can be…”
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Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy by Mizui, Tomokazu, Yamashina, Shunhei, Tanida, Isei, Takei, Yoshiyuki, Ueno, Takashi, Sakamoto, Naoya, Ikejima, Kenichi, Kitamura, Tsuneo, Enomoto, Nobuyuki, Sakai, Tatsuo, Kominami, Eiki, Watanabe, Sumio

“…Background Autophagy has been reported to play a pivotal role on the replication of various RNA viruses. In this study, we investigated the role of autophagy…”
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Reply to the letter “Autophagy and acetaminophen hepatotoxicity: how useful are Atg7-deficient mice?” by Yamashina, Shunhei

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Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease by Morinaga, Maki, Kon, Kazuyoshi, Uchiyama, Akira, Fukada, Hiroo, Fukuhara, Kyoko, Yaginuma, Reiko, Nakadera, Eisuke, Yamashina, Shunhei, Ikejima, Kenichi

“…Background The prevalence of nonalcoholic fatty liver disease (NAFLD) and alcohol-associated/related liver disease (ALD) with metabolic syndrome is increasing…”
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Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice by Ishizuka, Kei, Kon, Kazuyoshi, Lee‐Okada, Hyeon‐Cheol, Arai, Kumiko, Uchiyama, Akira, Yamashina, Shunhei, Yokomizo, Takehiko, Ikejima, Kenichi

“…Background and Aim Aging is an independent risk factor for the progression of non‐alcoholic steatohepatitis. Here, we investigated the role of age‐related…”
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Benefit of an action camera in endoscopy education for medical students under COVID-19 by Uchiyama, Akira, Yamashina, Shunhei, Sato, Toshifumi, Sakuma, Satoshi, Tomiki, Yuichi, Isayama, Hiroyuki, Nagahara, Akihito, Ikejima, Kenichi

“…Abstract Background Endoscopy is an important form of clinical gastroenterology education because it gives students the opportunity to learn about diagnosis…”
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The Chemical Chaperone 4‐Phenylbutyric Acid Prevents Alcohol‐Induced Liver Injury in Obese KK‐Ay Mice by Suzuki, Maiko, Kon, Kazuyoshi, Ikejima, Kenichi, Arai, Kumiko, Uchiyama, Akira, Aoyama, Tomonori, Yamashina, Shunhei, Ueno, Takashi, Watanabe, Sumio

“…Background Co‐occurrence of metabolic syndrome and chronic alcohol consumption is increasing worldwide. The present study investigated the effect of the…”
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Cathepsin L-deficiency enhances liver regeneration after partial hepatectomy by Sato, Toshifumi, Yamashina, Shunhei, Izumi, Kosuke, Ueno, Takashi, Koike, Masato, Ikejima, Kenichi, Peters, Christoph, Watanabe, Sumio

“…Cathepsin L (Ctsl) plays a pivotal role in lysosomal and autophagic proteolysis. Previous investigations revealed that partial hepatectomy (PH) decreases…”
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Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis by Nakadera, Eisuke, Yamashina, Shunhei, Izumi, Kousuke, Inami, Yoshihiro, Sato, Toshifumi, Fukushima, Hirofumi, Kon, Kazuyoshi, Ikejima, Kenichi, Ueno, Takashi, Watanabe, Sumio

“…Recent investigations revealed that dysfunction of autophagy involved in the progression of chronic liver diseases such as alcoholic and nonalcoholic…”
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Interleukin-11 links oxidative stress and compensatory proliferation by Nishina, Takashi, Komazawa-Sakon, Sachiko, Yanaka, Saeko, Piao, Xuehua, Zheng, Dong-Mei, Piao, Jiang-Hu, Kojima, Yuko, Yamashina, Shunhei, Sano, Emiko, Putoczki, Tracy, Doi, Takahiro, Ueno, Takashi, Ezaki, Junji, Ushio, Hiroko, Ernst, Matthias, Tsumoto, Kouhei, Okumura, Ko, Nakano, Hiroyasu

“…Apoptotic cells can stimulate the compensatory proliferation of surrounding cells to maintain tissue homeostasis. Although oxidative stress is associated with…”
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Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity by Takashima, Shiori, Ikejima, Kenichi, Arai, Kumiko, Yokokawa, Junko, Kon, Kazuyoshi, Yamashina, Shunhei, Watanabe, Sumio

“…Strategies for prevention and treatment of nonalcoholic steatohepatitis remain to be established. We evaluated the effect of glycine on metabolic…”
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Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease by Takeda, Kazuyoshi, Kojima, Yuko, Ikejima, Kenichi, Harada, Kenichi, Yamashina, Shunhei, Okumura, Kyoko, Aoyama, Tomonori, Frese, Steffen, Ikeda, Hiroko, Haynes, Nicole M, Cretney, Erika, Yagita, Hideo, Sueyoshi, Noriyoshi, Sato, Nobuhiro, Nakanuma, Yasuni, Smyth, Mark J, Okumura, Ko

“…Chronic cholestasis often results in premature death from liver failure with fibrosis; however, the molecular mechanisms contributing to biliary cirrhosis are…”
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A Customized Online Nutrition Guidance System Is Effective for Treating Patients with Nonalcoholic Fatty Liver Disease by Supporting Continuity of Diet Therapy at Home: A Pilot Study by Aoyama, Tomonori, Takada, Hidekatsu, Uchiyama, Akira, Kon, Kazuyoshi, Yamashina, Shunhei, Ikejima, Kenichi, Ban, Hideyuki, Watanabe, Sumio

“…Continuity is required for diet therapy, but it depends on patients. We examined the utility of a new tool, the customized online nutrition guidance system, in…”
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Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat by Ikejima, Kenichi, Takei, Yoshiyuki, Honda, Hajime, Hirose, Miyoko, Yoshikawa, Mutsuko, Zhang, Yan-Jun, Lang, Tie, Fukuda, Toru, Yamashina, Shunhei, Kitamura, Tsuneo, Sato, Nobuhiro

“…In this study, we investigated the role of leptin and its receptors (Ob-R) in profibrogenic responses in the liver using Zucker (fa/fa) rats, a natural…”
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L‐carnitine prevents metabolic steatohepatitis in obese diabetic KK‐Ay mice by Kon, Kazuyoshi, Ikejima, Kenichi, Morinaga, Maki, Kusama, Hiromi, Arai, Kumiko, Aoyama, Tomonori, Uchiyama, Akira, Yamashina, Shunhei, Watanabe, Sumio

“…Aim Pharmacological treatment for metabolic syndrome‐related non‐alcoholic steatohepatitis has not been established. We investigated the effect of L‐carnitine,…”
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