Search Results - "YAMASAKI, Motoo"

Activation of Calcitonin Gene-Related Peptide and Adrenomedullin Receptors by PEGylated Adrenomedullin by Akashi, Emiko, Nagata, Sayaka, Yamasaki, Motoo, Kitamura, Kazuo

“…Adrenomedullin (AM) improves colitis in animal models and patients with inflammatory bowel disease. We have developed a PEGylated AM derivative (PEG-AM) for…”
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Development of Long-Acting Human Adrenomedullin Fc-Fusion Proteins by Nagata, Sayaka, Yamasaki, Motoo, Kuroishi, Nobuko, Kitamura, Kazuo

“…(1) Background: Human adrenomedullin (hAM) is a hypotensive peptide hormone that exerts powerful anti-inflammatory effects. AM also had therapeutic effects in…”
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Anti‐Inflammatory Effects of PEGylated Human Adrenomedullin in a Mouse DSS‐Induced Colitis Model by Nagata, Sayaka, Yamasaki, Motoo, Kitamura, Kazuo

“…ABSTRACT Preclinical Research Human adrenomedullin (hAM), a hypotensive peptide, also has anti‐inflammatory effects. hAM can reduce the severity of the dextran…”
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Developments of human adrenomedullin-IgG1 Fc fusion proteins by Nagata, Sayaka, Yamasaki, Motoo, Kawano, Aya, Kitamura, Kazuo

“…Human adrenomedullin (hAM) is a hypotensive peptide hormone that exerts powerful anti-inflammatory effects. However, treatment required continuous…”
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The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity by Shinkawa, Toyohide, Nakamura, Kazuyasu, Yamane, Naoko, Shoji-Hosaka, Emi, Kanda, Yutaka, Sakurada, Mikiko, Uchida, Kazuhisa, Anazawa, Hideharu, Satoh, Mitsuo, Yamasaki, Motoo, Hanai, Nobuo, Shitara, Kenya

“…An anti-human interleukin 5 receptor (hIL-5R) humanized immunoglobulin G1 (IgG1) and an anti-CD20 chimeric IgG1 produced by rat hybridoma YB2/0 cell lines…”
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Identification of Highly Reactive Cysteine Residues at Less Exposed Positions in the Fab Constant Region for Site-Specific Conjugation by Shiraishi, Yasuhisa, Muramoto, Takashige, Nagatomo, Kazutaka, Shinmi, Daisuke, Honma, Emiko, Masuda, Kazuhiro, Yamasaki, Motoo

“…Engineered cysteine residues are currently used for the site-specific conjugation of antibody–drug conjugates (ADC). In general, positions on the protein…”
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Development of a novel human adrenomedullin derivative: human serum albumin-conjugated adrenomedullin by Kuroishi, Nobuko, Nagata, Sayaka, Akashi, Emiko, Ashizuka, Shinya, Kato, Johji, Yamasaki, Motoo, Kitamura, Kazuo

“…Abstract Adrenomedullin is a biologically active peptide with multiple functions. Here, we have developed a novel human serum albumin-adrenomedullin (HSA-AM)…”
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A Peptidomics Strategy for Discovering Endogenous Bioactive Peptides by Sasaki, Kazuki, Takahashi, Noriyuki, Satoh, Mitsuo, Yamasaki, Motoo, Minamino, Naoto

“…Peptide hormones and neuropeptides constitute an important class of naturally occurring peptides that are generated from precursor proteins by limited…”
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Molecular Characterization and Biological Function of Neuroendocrine Regulatory Peptide-3 in the Rat by Fujihara, Hiroaki, Sasaki, Kazuki, Mishiro-Sato, Emi, Ohbuchi, Toyoaki, Dayanithi, Govindan, Yamasaki, Motoo, Ueta, Yoichi, Minamino, Naoto

“…Neuroendocrine regulatory peptide (NERP)-3, derived from the neurosecretory protein VGF (non-aconymic), is a new biologically active peptide identified through…”
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20 kDa PEGylated Adrenomedullin as a New Therapeutic Candidate for Inflammatory Bowel Disease by Miki, Goro, Kuroishi, Nobuko, Tokashiki, Mariko, Nagata, Sayaka, Tamura, Masaji, Yoshiya, Taku, Yoshizawa-Kumagaye, Kumiko, Ashizuka, Shinya, Kato, Joji, Yamasaki, Motoo, Kitamura, Kazuo

“…Human adrenomedullin (AM), a hypotensive peptide, also has anti-colitis activity. We prepared a polyethylene glycol (PEG) ylated form of AM through the…”
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Increasing Effect of an Oral Intake of L-Hydroxyproline on the Soluble Collagen Content of Skin and Collagen Fragments in Rat Serum by AOKI, Mami, SUTO, Kouzou, KOMATSU, Miho, KAMIMURA, Ayako, MORISHITA, Koji, YAMASAKI, Motoo, TAKAO, Toshifumi

“…We examined the effects of oral L-hydroxyproline (Hyp) on collagen in the body. After 2 weeks' administration of Hyp (0.5 or 1 g/kg) to F344 male rats, the…”
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Preparation and properties of branched oligoglycerol modifiers for stabilization of liposomes by Ishihara, Atsushi, Yamauchi, Masahiro, Kusano, Hiroko, Mimura, Yukiteru, Nakakura, Masashi, Kamiya, Masaaki, Katagiri, Ayato, Kawano, Masaki, Nemoto, Hisao, Suzawa, Toshiyuki, Yamasaki, Motoo

“…We examined the effect on drug delivery of liposomes with surfaces that were modified with branched oligoglycerols (BGLs) and explored possible formulation…”
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Modification of protein with BGL06, a novel branched oligoglycerol derivative by Hiroyuki, Yamaguchi, Toshiyuki, Suzawa, Takaaki, Araki, Masaki, Kamiya, Hisao, Nemoto, Motoo, Yamasaki

“…A branched oligoglycerol derivative, BGL06, with a cascade-like structure of glycerol units was used as a novel reagent for protein modification. Modification…”
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Specific Targeting, Biodistribution, and Lack of Immunogenicity of Chimeric Anti-GD3 Monoclonal Antibody KM871 in Patients With Metastatic Melanoma: Results of a Phase I Trial by SCOTT, Andrew M, LEE, Fook-Thean, HANAI, Nobuo, INOUE, Kengo, YAMASAKI, Motoo, BRECHBIEL, Martin W, DAVIS, Ian D, MURPHY, Roger, HANNAH, Anthony, LIM-JOON, Michael, CHAN, Tony, CHONG, Geoffrey, HOPKINS, Wendie, RITTER, Gerd, HOFFMAN, Eric W, BURGESS, Antony W, OLD, Lloyd J, CEBON, Jonathan S, WHEATLEY, Jennifer M, ZHANQI LIU, SMYTH, Fiona E, MURONE, Carmel, STURROCK, Susan, MACGREGOR, Duncan

“…KM871 is a chimeric monoclonal antibody against the ganglioside antigen GD3, which is highly expressed on melanoma cells. We conducted an open-label, dose…”
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PS-BPB09-2: DEVELOPMENT OF LONG-ACTING HUMAN ADRENOMEDULLIN FC FUSION PROTEINS by Nagata, Sayaka, Yamasaki, Motoo, Kuroishi, Nobuko, Kitamura, Kazuo

“…Background: Human adrenomedullin (hAM) is a hypotensive peptide hormone with strong anti-inflammatory effects. AM consists of 52 amino acid residues with an…”
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Polyethylene glycol-conjugated human adrenomedullin as a possible treatment for vascular dementia by Nagata, Sayaka, Yamasaki, Motoo, Kitamura, Kazuo

“…•A long-acting human AM derivative was conjugated with 60 kDa PEG.•PEG-AM treatment reduced the escape latency of mice in a hidden platform test.•PEG-AM…”
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Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein by Bowen, Sharon, Tare, Nadine, Inoue, Tomoaki, Yamasaki, Motoo, Okabe, Masami, Horii, Ikuo, Eliason, James F

“…Proteins conjugated with polyethylene glycol (PEG) have increased in vivo activity compared to native proteins. We examined the activity of a variety of PEG…”
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Abstract P334: Persistent Adrenomedullin Derivative Inhibits Development of Hypertension by Nagata, Sayaka, Yamasaki, Motoo, Kitamura, Kazuo

“…Abstract only Human adrenomedullin (hAM) consists of a 52 amino acid peptide that is amidated and has a disulfide bond. The bioactive peptide hAM has a variety…”
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Synthesis of a novel duocarmycin derivative DU-257 and its application to immunoconjugate using poly(ethylene glycol)-dipeptidyl linker capable of tumor specific activation by SUZAWA, T, NAGAMURA, S, SAITO, H, OHTA, S, HANAI, N, YAMASAKI, M

“…Novel anti-tumor agent, duocarmycin derivative DU-257, was designed and synthesized to prepare immunoconjugate in order to confirm the feasibility of…”
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Somatostatin-, Vasoactive Intestinal Peptide-, and Granulin-like Peptides Isolated from Intestinal Extracts of Goldfish, Carassius auratus by Uesaka, Toshihiro, Yano, Kenchi, Yamasaki, Motoo, Ando, Masaaki

“…Three new peptides were originally isolated from intestinal extracts of goldfish. They were structurally related with somatostatin, vasoactive intestinal…”
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