Search Results - "YAMANO, Shotaro"

Anti‐PD‐L1 treatment enhances antitumor effect of everolimus in a mouse model of renal cell carcinoma by Hirayama, Yukiyoshi, Gi, Min, Yamano, Shotaro, Tachibana, Hirokazu, Okuno, Takahiro, Tamada, Satoshi, Nakatani, Tatsuya, Wanibuchi, Hideki

“…Immunotherapy based on blockade of the programmed death‐1 (PD‐1)/programmed death‐ligand 1 (PD‐L1) axis has shown promising clinical activity for renal cell…”
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Nuclear import of IER5 is mediated by a classical bipartite nuclear localization signal and is required for HSF1 full activation by Yamano, Shotaro, Kimura, Makoto, Chen, Yu, Imamoto, Naoko, Ohki, Rieko

“…IER5 gene encodes an activator of HSF1 and is a p53 target gene. The IER5 protein forms a ternary complex with HSF1 and PP2A, and promotes PP2A-dependent…”
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Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model by Goto, Yuko, Saito, Arata, Takanobu, Kenji, Senoh, Hideki, Saito, Misae, Umeda, Yumi, Yamano, Shotaro

“…2-Bromopropane (2-BP) is a colorless liquid at room temperature and is used in closed systems in factories, mainly as an intermediate for medicines,…”
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Distribution of genetic alterations in high-risk early-stage cervical cancer patients treated with postoperative radiation therapy by Murakami, Naoya, Asami, Yuka, Yoshida, Hiroshi, Takayanagi, Daisuke, Hirose, Sou, Kuno, Ikumi, Takahashi, Kazuaki, Matsuda, Maiko, Shimada, Yoko, Yamano, Shotaro, Sunami, Kuniko, Honda, Takayuki, Nakahara, Tomomi, Watanabe, Tomoko, Okuma, Kae, Kuroda, Takafumi, Kohno, Takashi, Kato, Tomoyasu, Shiraishi, Kouya, Itami, Jun

“…Somatic genetic alteration analysis was performed for post-hysterectomy high-risk early-stage uterine cervical cancer patients who underwent post-operative…”
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Respiratory disease in workers handling cross-linked water-soluble acrylic acid polymer by Kishimoto, Takumi, Okamoto, Kenzo, Koda, Shigeki, Ono, Mariko, Umeda, Yumi, Yamano, Shotaro, Takeda, Tomoki, Rai, Kammei, Kato, Katsuya, Nishimura, Yasumitsu, Kobashi, Yoichiro, Kawamura, Tetsuji

“…Eight workers involved in packing cross-linked water-soluble acrylic acid polymer, an organic substance, developed pulmonary fibrosis, and the upper lobe was…”
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Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway by Inaba, Hironori, Goto, Hidemasa, Kasahara, Kousuke, Kumamoto, Kanako, Yonemura, Shigenobu, Inoko, Akihito, Yamano, Shotaro, Wanibuchi, Hideki, He, Dongwei, Goshima, Naoki, Kiyono, Tohru, Hirotsune, Shinji, Inagaki, Masaki

“…Primary cilia protrude from the surface of quiescent cells and disassemble at cell cycle reentry. We previously showed that ciliary reassembly is suppressed by…”
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Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study by Yamano, Shotaro, Goto, Yuko, Takeda, Tomoki, Hirai, Shigeyuki, Furukawa, Yusuke, Kikuchi, Yoshinori, Kasai, Tatsuya, Misumi, Kyohei, Suzuki, Masaaki, Takanobu, Kenji, Senoh, Hideki, Saito, Misae, Kondo, Hitomi, Umeda, Yumi

“…Most toxicological studies on titanium dioxide (TiO.sub.2) particles to date have concentrated on carcinogenicity and acute toxicity, with few studies focusing…”
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Genomic alterations in STK11 can predict clinical outcomes in cervical cancer patients by Hirose, Sou, Murakami, Naoya, Takahashi, Kazuaki, Kuno, Ikumi, Takayanagi, Daisuke, Asami, Yuka, Matsuda, Maiko, Shimada, Yoko, Yamano, Shotaro, Sunami, Kuniko, Yoshida, Kazushi, Honda, Takayuki, Nakahara, Tomomi, Watanabe, Tomoko, Komatsu, Masaaki, Hamamoto, Ryuji, Kato, Mayumi Kobayashi, Matsumoto, Koji, Okuma, Kae, Kuroda, Takafumi, Okamoto, Aikou, Itami, Jun, Kohno, Takashi, Kato, Tomoyasu, Shiraishi, Kouya, Yoshida, Hiroshi

“…Cervical cancer is the fourth most common cause of cancer-related deaths in Asian women, due to its poor prognosis. This study aimed to decipher genomic…”
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No evidence for carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model by Yamano, Shotaro, Takeda, Tomoki, Goto, Yuko, Hirai, Shigeyuki, Furukawa, Yusuke, Kikuchi, Yoshinori, Kasai, Tatsuya, Misumi, Kyohei, Suzuki, Masaaki, Takanobu, Kenji, Senoh, Hideki, Saito, Misae, Kondo, Hitomi, Umeda, Yumi

“…With the rapid development of alternative methods based on the spirit of animal welfare, the publications of animal studies evaluating endpoints such as cancer…”
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Carcinogenicity and chronic toxicity of acrolein in rats and mice by two-year inhalation study by Matsumoto, Michiharu, Yamano, Shotaro, Senoh, Hideki, Umeda, Yumi, Hirai, Shigeyuki, Saito, Arata, Kasai, Tatsuya, Aiso, Shigetoshi

“…The carcinogenicity and chronic toxicity of acrolein was examined by whole body inhalation to groups of 50 F344/DuCrlCrlj rats and 50 B6D2F1/Crlj mice of both…”
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Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway by Nakai, Kazuki, Lin, Hancheng, Yamano, Shotaro, Tanaka, Shinya, Kitamoto, Sho, Saitoh, Hitoshi, Sakuma, Kenta, Kurauchi, Junpei, Akter, Eilma, Konno, Masamitsu, Ishibashi, Kojiro, Kamata, Ryo, Ohashi, Akihiro, Koseki, Jun, Takahashi, Hirotaka, Yokoyama, Hideshi, Shiraki, Yukihiro, Enomoto, Atsushi, Abe, Sohei, Hayakawa, Yoku, Ushiku, Tetsuo, Mutoh, Michihiro, Fujita, Yasuyuki, Kon, Shunsuke

“…Normal epithelial cells exert their competitive advantage over RasV12-transformed cells and eliminate them into the apical lumen via cell competition. However,…”
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Role of deltaNp63posCD44vpos cells in the development of N‐nitroso‐tris‐chloroethylurea‐induced peripheral‐type mouse lung squamous cell carcinomas by Yamano, Shotaro, Gi, Min, Tago, Yoshiyuki, Doi, Kenichiro, Okada, Satoshi, Hirayama, Yukiyoshi, Tachibana, Hirokazu, Ishii, Naomi, Fujioka, Masaki, Tatsumi, Kumiko, Wanibuchi, Hideki

“…The role of cells expressing stem cell markers deltaNp63 and CD44v has not yet been elucidated in peripheral‐type lung squamous cell carcinoma (pLSCC)…”
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Mechanisms of pulmonary disease in F344 rats after workplace-relevant inhalation exposure to cross-linked water-soluble acrylic acid polymers by Yamano, Shotaro, Takeda, Tomoki, Goto, Yuko, Hirai, Shigeyuki, Furukawa, Yusuke, Kikuchi, Yoshinori, Misumi, Kyohei, Suzuki, Masaaki, Takanobu, Kenji, Senoh, Hideki, Saito, Misae, Kondo, Hitomi, Kobashi, Yoichiro, Okamoto, Kenzo, Kishimoto, Takumi, Umeda, Yumi

“…Recently in Japan, six workers at a chemical plant that manufactures resins developed interstitial lung diseases after being involved in loading and packing…”
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Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2 by Osawa, Tsuyoshi, Shimamura, Teppei, Saito, Kyoko, Hasegawa, Yoko, Ishii, Naoko, Nishida, Miyuki, Ando, Ritsuko, Kondo, Ayano, Anwar, Muyassar, Tsuchida, Rika, Hino, Shinjiro, Sakamoto, Akihisa, Igarashi, Kaori, Saitoh, Kaori, Kato, Keiko, Endo, Keiko, Yamano, Shotaro, Kanki, Yasuharu, Matsumura, Yoshihiro, Minami, Takashi, Tanaka, Toshiya, Anai, Motonobu, Wada, Youichiro, Wanibuchi, Hideki, Hayashi, Mitsuhiro, Hamada, Akinobu, Yoshida, Masayuki, Yachida, Shinichi, Nakao, Mitsuyoshi, Sakai, Juro, Aburatani, Hiroyuki, Shibuya, Masabumi, Hanada, Kentaro, Miyano, Satoru, Soga, Tomoyoshi, Kodama, Tatsuhiko

“…Tolerance to severe tumor microenvironments, including hypoxia and nutrient starvation, is a common feature of aggressive cancer cells and can be targeted…”
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Lung carcinogenicity by whole body inhalation exposure to Anatase-type Nano-titanium Dioxide in rats by Kasai, Tatsuya, Hirai, Shigeyuki, Furukawa, Yuske, Misumi, Kyouhei, Takeda, Tomoki, Goto, Yuko, Takanobu, Kenji, Yoneyama, Kengo, Yamano, Shotaro, Senoh, Hideki, Umeda, Yumi

“…To investigate the carcinogenicity of anatase-type nano-titanium dioxide (aNTiO2), F344/DuCrlCrlj rats were exposed to aNTiO2 aerosol at concentrations of 0,…”
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Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats by Takeda, Tomoki, Yamano, Shotaro, Goto, Yuko, Hirai, Shigeyuki, Furukawa, Yusuke, Kikuchi, Yoshinori, Misumi, Kyohei, Suzuki, Masaaki, Takanobu, Kenji, Senoh, Hideki, Saito, Misae, Kondo, Hitomi, Daghlian, George, Hong, Young-Kwon, Yoshimatsu, Yasuhiro, Hirashima, Masanori, Kobashi, Yoichiro, Okamoto, Kenzo, Kishimoto, Takumi, Umeda, Yumi

“…In Japan, six workers handling cross-linked water-soluble acrylic acid polymer (CWAAP) at a chemical plant suffered from lung diseases, including fibrosis,…”
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Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis by Kakehashi, Anna, Chariyakornkul, Arpamas, Suzuki, Shugo, Khuanphram, Napaporn, Tatsumi, Kumiko, Yamano, Shotaro, Fujioka, Masaki, Gi, Min, Wongpoomchai, Rawiwan, Wanibuchi, Hideki

“…In the present study, potential molecular biomarkers of NASH hepatocarcinogenesis were investigated using the STAM mice NASH model, characterized by impaired…”
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DDX39 acts as a suppressor of invasion for bladder cancer by Kato, Minoru, Wei, Min, Yamano, Shotaro, Kakehashi, Anna, Tamada, Satoshi, Nakatani, Tatsuya, Wanibuchi, Hideki

“…The object of the present study was to identify markers for predicting urinary bladder cancer progression by comparative proteome analysis of bladder cancers…”
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Correction to: Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats by Takeda, Tomoki, Yamano, Shotaro, Goto, Yuko, Hirai, Shigeyuki, Furukawa, Yusuke, Kikuchi, Yoshinori, Misumi, Kyohei, Suzuki, Masaaki, Takanobu, Kenji, Senoh, Hideki, Saito, Misae, Kondo, Hitomi, Daghlian, George, Hong, Young-Kwon, Yoshimatsu, Yasuhiro, Hirashima, Masanori, Kobashi, Yoichiro, Okamoto, Kenzo, Kishimoto, Takumi, Umeda, Yumi

“…Graphic abstract…”
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CDCP1 promotes compensatory renal growth by integrating Src and Met signaling by Kajiwara, Kentaro, Yamano, Shotaro, Aoki, Kazuhiro, Okuzaki, Daisuke, Matsumoto, Kunio, Okada, Masato

“…Compensatory growth of organs after loss of their mass and/or function is controlled by hepatocyte growth factor (HGF), but the underlying regulatory…”
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