Search Results - "YAMANE, JUNKO"

Novel computational model of gastrula morphogenesis to identify spatial discriminator genes by self-organizing map (SOM) clustering by Mori, Tomoya, Takaoka, Haruka, Yamane, Junko, Alev, Cantas, Fujibuchi, Wataru

“…Deciphering the key mechanisms of morphogenesis during embryonic development is crucial to understanding the guiding principles of the body plan and promote…”
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Sialomucin and phosphorylated-ERM are inhibitors for cadherin-mediated aggregate formation by Tachibana, Kouichi, Yamane, Junko, Haghparast, Seyed Mohammad Ali, Miyake, Jun

“…Cell adhesion is mediated by adhesion molecules, but also regulated by adhesion inhibitory molecules. Molecules such as leukocyte sialomucin and…”
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eSPRESSO: topological clustering of single-cell transcriptomics data to reveal informative genes for spatio-temporal architectures of cells by Mori, Tomoya, Takase, Toshiro, Lan, Kuan-Chun, Yamane, Junko, Alev, Cantas, Kimura, Azuma, Osafune, Kenji, Yamashita, Jun K, Akutsu, Tatsuya, Kitano, Hiroaki, Fujibuchi, Wataru

“…Bioinformatics capability to analyze spatio-temporal dynamics of gene expression is essential in understanding animal development. Animal cells are spatially…”
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Human ES and iPS cells display less drug resistance than differentiated cells, and naïve-state induction further decreases drug resistance by Panina, Yulia, Yamane, Junko, Kobayashi, Kenta, Sone, Hideko, Fujibuchi, Wataru

“…Pluripotent stem cells (PSCs) possess unique characteristics that distinguish them from other cell types. Human embryonic stem (ES) cells are recently gaining…”
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Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells by Yamane, Junko, Aburatani, Sachiyo, Imanishi, Satoshi, Akanuma, Hiromi, Nagano, Reiko, Kato, Tsuyoshi, Sone, Hideko, Ohsako, Seiichiroh, Fujibuchi, Wataru

“…Predictive toxicology using stem cells or their derived tissues has gained increasing importance in biomedical and pharmaceutical research. Here, we show that…”
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SERPINI1 regulates epithelial–mesenchymal transition in an orthotopic implantation model of colorectal cancer by Matsuda, Yasufumi, Miura, Koh, Yamane, Junko, Shima, Hiroshi, Fujibuchi, Wataru, Ishida, Kazuyuki, Fujishima, Fumiyoshi, Ohnuma, Shinobu, Sasaki, Hiroyuki, Nagao, Munenori, Tanaka, Naoki, Satoh, Kennichi, Naitoh, Takeshi, Unno, Michiaki

“…An increasingly accepted concept is that the progression of colorectal cancer is accompanied by epithelial–mesenchymal transition (EMT). In our study, in order…”
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AMPK activation reverts mouse epiblast stem cells to naive state by Liu, Yajing, Yamane, Junko, Tanaka, Akito, Fujibuchi, Wataru, Yamashita, Jun K.

“…Despite increasing knowledge on primed and naive pluripotency, the cell signaling that regulates the pluripotency type in stem cells remains not fully…”
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Real-time imaging of interaction between macrophages and lymphatic vessels in an in vitro model to study inflammatory resolution by Matsumoto-Okazaki, Yuko, Yamane, Junko, Kajiya, Kentaro

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Effects of methylmercury exposure on neuronal differentiation of mouse and human embryonic stem cells by He, Xiaoming, Imanishi, Satoshi, Sone, Hideko, Nagano, Reiko, Qin, Xian-Yang, Yoshinaga, Jun, Akanuma, Hiromi, Yamane, Junko, Fujibuchi, Wataru, Ohsako, Seiichiroh

“…► Novel EST systems using mESC- and hESC-derived neural developmental models were established. ► Toxicity of MeHg was examined using functional, morphological,…”
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Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic by Yamane, Junko, Kubo, Akiharu, Nakayama, Kazuhisa, Yuba-Kubo, Akiko, Katsuno, Tatsuya, Tsukita, Shoichiro, Tsukita, Sachiko

“…The small GTPase Rab6 regulates retrograde membrane traffic from endosomes to the Golgi apparatus and from the Golgi to the endoplasmic reticulum (ER). We…”
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Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells by YAMANEGI, KOJI, YAMANE, JUNKO, KOBAYASHI, KENTA, OHYAMA, HIDEKI, NAKASHO, KEIJI, YAMADA, NAOKO, HATA, MASAKI, FUKUNAGA, SATORU, FUTANI, HIROYUKI, OKAMURA, HARUKI, TERADA, NOBUYUKI

“…Valproic acid, a histone deacetylase inhibitor, increases the expression of cell surface MHC class I-related chain molecules (MICs) A and B (MICA and B) in…”
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Formation of microvilli and phosphorylation of ERM family proteins by CD43, a potent inhibitor for cell adhesion: Cell detachment is a potential cue for ERM phosphorylation and organization of cell morphology by Yamane, Junko, Ohnishi, Hiroe, Sasaki, Hiroyuki, Narimatsu, Hisashi, Ohgushi, Hajime, Tachibana, Kouichi

“…CD43/sialophorin/leukosialin, a common leukocyte antigen, is known as an inhibitor for cell adhesion. The ectodomain of CD43 is considered as a molecular…”
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ヒトES細胞を用いた高精度の化合物毒性予測システムの構築 by 山根, 順子, 油谷, 幸代, 今西, 哲, 赤沼, 宏美, 永野, 麗子, 加藤, 毅, 曽根, 秀子, 大迫, 誠一郎, 藤渕, 航

“…「はじめに」創薬において化合物の毒性評価は必須であるが, 倫理的にも直接人体への毒性影響を検証することは難しく, 従来は動物モデルを用いた検証が行われてきた. しかしながら, 動物体内の作用機序と人体内の作用機序が異なることも少なくないため, 動物モデルを用いて検証された結果を直接ヒトに外挿できない場合がある…”
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Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus by Kamatani, Takashi, Hagizawa, Hiroki, Yarimitsu, Seido, Morioka, Miho, Koyamatsu, Saeko, Sugimoto, Michihiko, Kodama, Joe, Yamane, Junko, Ishiguro, Hiroyuki, Shichino, Shigeyuki, Abe, Kuniya, Fujibuchi, Wataru, Fujie, Hiromichi, Kaito, Takashi, Tsumaki, Noriyuki

“…The loss of nucleus pulposus (NP) precedes the intervertebral disk (IVD) degeneration that causes back pain. Here, we demonstrate that the implantation of…”
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Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells by Yamane, Junko, Aburatani, Sachiyo, Imanishi, Satoshi, Akanuma, Hiromi, Nagano, Reiko, Kato, Tsuyoshi, Sone, Hideko, Ohsako, Seiichiroh, Fujibuchi, Wataru

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Construction of a High-precision Chemical Prediction System Using Human ESCs by Yamane, Junko, Aburatani, Sachiyo, Imanishi, Satoshi, Akanuma, Hiromi, Nagano, Reiko, Kato, Tsuyoshi, Sone, Hideko, Ohsako, Seiichiroh, Fujibuchi, Wataru

“…Toxicity prediction based on stem cells and tissue derived from stem cells plays a very important role in the fields of biomedicine and pharmacology. Here we…”
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Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death by YAMANEGI, Koji, YAMANE, Junko, OKAMURA, Haruki, TERADA, Nobuyuki, KOBAYASHI, Kenta, KATO-KOGOE, Nahoko, OHYAMA, Hideki, NAKASHO, Keui, YAMADA, Naoko, HATA, Masaki, FUKUNAGA, Satoru, FUTANI, Hiroyuki

“…We investigated the effects of valproic acid (VPA), a histone deacetylase inhibitor, in combination with hydralazine, a DNA methylation inhibitor, on the…”
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Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity by YAMANEGI, Koji, YAMANE, Junko, FUTANI, Hiroyuki, OKAMURA, Haruki, TERADA, Nobuyuki, KOBAYASHI, Kenta, KATO-KOGOE, Nahoko, OHYAMA, Hideki, NAKASHO, Keiji, YAMADA, Naoko, HATA, Masaki, NISHIOKA, Toshihiro, FUKUNAGA, Satoru

“…MHC class I-related chain molecules A and B (MICA and B) expressed on the cell-surface of tumor cells are ligands for an activating receptor, NKG2D, expressed…”
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StemPanTox: A fast and wide-target drug assessment system for tailor-made safety evaluations using personalized iPS cells by Yamane, Junko, Wada, Takumi, Otsuki, Hironori, Inomata, Koji, Suzuki, Mutsumi, Hisaki, Tomoka, Sekine, Shuichi, Kouzuki, Hirokazu, Kobayashi, Kenta, Sone, Hideko, Yamashita, Jun K., Osawa, Mitsujiro, Saito, Megumu K., Fujibuchi, Wataru

“…An alternative model that reliably predicts human-specific toxicity is necessary because the translatability of effects on animal models for human disease is…”
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Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death by Yamanegi, Koji, Yamane, Junko, Hata, Masaki, Ohyama, Hideki, Yamada, Naoko, Kato-Kogoe, Nahoko, Futani, Hiroyuki, Nakasho, Keiji, Okamura, Haruki, Terada, Nobuyuki

“…Purpose Effects of valproic acid (VPA), a histone deacetylase inhibitor, on the susceptibility to cell death induced by agonistic anti-Fas antibody were…”
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