Search Results - "YAMAMOTO, KOUJIROU"

Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants by Yamaguchi, Yuki, Akiyoshi, Takeshi, Kawamura, Go, Imaoka, Ayuko, Miyazaki, Mitsue, Guengerich, F. Peter, Nakamura, Katsunori, Yamamoto, Koujirou, Ohtani, Hisakazu

“…Cytochrome P450 (CYP) 3A4 is one of the major drug-metabolizing enzymes. Genetic variants of CYP3A4 with altered activity are one of the factors responsible…”
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Patient resuscitated after cardiopulmonary arrest exhibits abnormally increased phenytoin metabolic rate due to unknown factors: a case report by Nagamine, Ayumu, Araki, Takuya, Yashima, Hideaki, Oshima, Kiyohiro, Obayashi, Kyoko, Yamamoto, Koujirou

“…Fosphenytoin (FOS) is a prodrug of phenytoin (PHT) with a metabolism that exhibits Michaelis-Menten-type kinetics. Genetic polymorphisms of the metabolic…”
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Blood Concentration of Cabazitaxel in a Patient Whose General Condition Worsened with Concomitant Use of Clarithromycin by Katsumi, Shigeaki, Araki, Takuya, Yashima, Hideaki, Miyazawa, Yoshiyuki, Suzuki, Kazuhiro, Yamamoto, Koujirou

“…Abstract We encountered a case in which the general condition of a patient receiving cabazitaxel worsened with concomitant use of clarithromycin. Cabazitaxel…”
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The influence of Javanese turmeric (Curcuma xanthorrhiza) on the pharmacokinetics of warfarin in rats with single and multiple-dose studies by Rusdiana, Taofik, Mardhiani, Yanni D., Putriana, Norisca A., Gozali, Dolih, Nagano, Daisuke, Araki, Takuya, Yamamoto, Koujirou

“…Co-administration between warfarin (WF) and Curcuma xanthorrhiza Roxb. (Zingiberaceae) (CX) is found in Indonesian patients and need to be evaluated. This…”
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Influence of Hemodynamic Variations on the Pharmacokinetics of Landiolol in Patients Undergoing Cardiovascular Surgery by Matsumoto, Naoki, Aomori, Tohru, Kanamoto, Masafumi, Usui, Tadashi, Shiga, Tatsuya, Yamamoto, Koujirou, Saito, Shigeru

“…Although landiolol is useful in the emergency management of atrial fibrillation, atrial flutter, and tachycardia, as well as in perioperative arrhythmia…”
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Mechanism-based Inhibition Profiles of Erythromycin and Clarithromycin with Cytochrome P450 3A4 Genetic Variants by Akiyoshi, Takeshi, Ito, Marie, Murase, Saori, Miyazaki, Mitsue, Peter Guengerich, F., Nakamura, Katsunori, Yamamoto, Koujirou, Ohtani, Hisakazu

“…Inhibition of cytochrome P450 (CYP) 3A4 is the major cause of drug-drug interactions (DDI). We have previously reported that the genetic variation of CYP3A4…”
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Defective Activity of Recombinant Cytochromes P450 3A4.2 and 3A4.16 in Oxidation of Midazolam, Nifedipine, and Testosterone by MIYAZAKI, Mitsue, NAKAMURA, Katsunori, FUJITA, Yukiyoshi, GUENGERICH, F. Peter, HORIUCHI, Ryuya, YAMAMOTO, Koujirou

“…Cytochrome P4503A4 (CYP3A4) is the most abundant cytochrome P450 in adult human liver and small intestine and oxidizes numerous clinically, physiologically,…”
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Ruthenium-Catalyzed Cycloisomerization and Its Application to the Synthesis of (±)-Cinchonaminone by Ogawa, Takao, Nakamura, Tomonori, Araki, Takuya, Yamamoto, Koujirou, Shuto, Satoshi, Arisawa, Mitsuhiro

“…Ru‐catalyzed cycloisomerization of a 1,3‐diene and the alkene of an N‐dienyl‐2‐vinylaniline substrate proceeded smoothly, leading to a…”
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Risk of Falling and Hypnotic Drugs: Retrospective Study of Inpatients by Obayashi, Kyoko, Araki, Takuya, Nakamura, Katsunori, Kurabayashi, Masahiko, Nojima, Yoshihisa, Hara, Katsuyuki, Nakamura, Tomonori, Yamamoto, Koujirou

“…Background Falls and related injuries remain a concern for patient safety in many hospitals and nursing care facilities. In particular, reports examining the…”
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Comparison of the Inhibitory Profiles of Itraconazole and Cimetidine in Cytochrome P450 3A4 Genetic Variants by AKIYOSHI, Takeshi, SAITO, Takashi, MURASE, Saori, MIYAZAKI, Mitsue, MURAYAMA, Norie, YAMAZAKI, Hiroshi, GUENGERICH, F. Peter, NAKAMURA, Katsunori, YAMAMOTO, Koujirou, OHTANI, Hisakazu

“…CYP3A4, an important drug-metabolizing enzyme, is known to have genetic variants. We have previously reported that CYP3A4 variants such as CYP3A4.2, 7, 16, and…”
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Quantitative evaluation of biliary elimination of gadoxetate, a magnetic resonance imaging contrast agent, via geometrical isomer-specific transporting system in rats by Ogawa, Junji, Yokota, Azusa, Araki, Takuya, Aomori, Tohru, Nakamura, Tomonori, Yamamoto, Koujirou, Koshiishi, Ichiro

“…ABSTRACT Gadoxetate, a magnetic resonance imaging contrast agent, is eliminated into bile. Gadoxetate geometrical isomers are chromatographically classified…”
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Rapid Single-Nucleotide Polymorphism Detection of Cytochrome P450 (CYP2C9) and Vitamin K Epoxide Reductase (VKORC1) Genes for the Warfarin Dose Adjustment by the SMart-Amplification Process Version 2 by Aomori, Tohru, Yamamoto, Koujirou, Oguchi-Katayama, Atsuko, Kawai, Yuki, Ishidao, Takefumi, Mitani, Yasumasa, Kogo, Yasushi, Lezhava, Alexander, Fujita, Yukiyoshi, Obayashi, Kyoko, Nakamura, Katsunori, Kohnke, Hugo, Wadelius, Mia, Ekstrom, Lena, Skogastierna, Cristine, Rane, Anders, Kurabayashi, Masahiko, Murakami, Masami, Cizdziel, Paul E, Hayashizaki, Yoshihide, Horiuchi, Ryuya

“…Polymorphisms of the CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9) gene (CYP2C9*2, CYP2C9*3) and the VKORC1 (vitamin K epoxide reductase…”
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Human kidneys play an important role in the elimination of propofol by TAKIZAWA, Daisuke, HIRAOKA, Haruhiko, GOTO, Fumio, YAMAMOTO, Koujirou, HORIUCHI, Ryuya

“…Extrahepatic clearance of propofol has been suggested because its total body clearance exceeds hepatic blood flow. However, it remains uncertain which organs…”
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Review of the Treatment of Non-Small Cell Lung Cancer with Gefitinib by Araki, Takuya, Yashima, Hideaki, Shimizu, Kimihiro, Aomori, Tohru, Hashita, Tadahiro, Kaira, Kyoichi, Nakamura, Tomonori, Yamamoto, Koujirou

“…In the past decade, molecular-targeted drugs have been focused upon for the treatment of cancer. In 2002, gefitinib, an epidermal growth factor receptor (EGFR)…”
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Effect of genetic polymorphisms on effectiveness of low-dose azathioprine in Japanese patients with systemic lupus erythematosus by Nagamine, Ayumu, Takenaka, Miki, Aomori, Tohru, Okada, Yuko, Hiromura, Keiju, Nojima, Yoshihisa, Araki, Takuya, Nakamura, Tomonori, Yamamoto, Koujirou

“…The effect of genetic polymorphisms on the effectiveness of low-dose azathioprine in Japanese patients with systemic lupus erythematosus (SLE) was studied…”
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Pharmacy residency system in Gunma University Hospital by Matsushita, Asami, Nagano, Daisuke, Shimone, Mikako, Obayashi, Kyoko, Araki, Takuya, Yamamoto, Koujirou

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Determination of Isepamicin in Human Plasma by HPLC with Fluorescence Detection after Derivatization Using 6-Aminoquinolyl-N-hydroxysuccinimidyl-carbamate by Hosokawa, Shin, Nakamura, Katsunori, Fujita, Yukiyoshi, Horiuchi, Ryuya, Yamamoto, Koujirou

“…A simple and rapid high-performance liquid chromatographic method has been developed for determination in human plasma of isepamicin (ISP), an aminoglycoside…”
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Significance of three step prescription checking by pharmacists by Shimone, Mikako, Nagano, Daisuke, Matsushita, Asami, Tsukamoto, Junko, Yanai, Yu, Kaneta, Akiko, Obayashi, Kyoko, Araki, Takuya, Yamamoto, Koujirou

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Effect of Ethanol in Paclitaxel Injections on the Ethanol Concentration in Exhaled Breath by Aomori, Tohru, Makino, Hironori, Sekizuka, Masayuki, Hashita, Tadahiro, Araki, Takuya, Iizuka, Keiko, Nakamura, Tomonori, Yamamoto, Koujirou

“…Background Ethanol is included in certain injectable preparations of anticancer drugs to increase their solubility. Since the volume of ethanol in these…”
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Prediction of total propofol clearance based on enzyme activities in microsomes from human kidney and liver by AL-JAHDARI, Wael S, YAMAMOTO, Koujirou, HIRAOKA, Haruhiko, NAKAMURA, Katsunori, GOTO, Fumio, HORIUCHI, Ryuya

“…Propofol is commonly used for anesthesia and sedation in intensive care units. Approximately 53% of injected propofol is excreted in the urine as the…”
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