Search Results - "YAMAMOTO, K. R"

An affective disorder in zebrafish with mutation of the glucocorticoid receptor by Ziv, L, Muto, A, Schoonheim, P J, Meijsing, S H, Strasser, D, Ingraham, H A, Schaaf, M J M, Yamamoto, K R, Baier, H

“…Upon binding of cortisol, the glucocorticoid receptor (GR) regulates the transcription of specific target genes, including those that encode the stress…”
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The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain by Nissen, Robert M., Yamamoto, Keith R.

“…Glucocorticoids repress NFκB-mediated activation of proinflammatory genes such as interleukin-8 (IL-8) and ICAM-1. Our experiments suggest that the…”
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Allosteric effects of DNA on transcriptional regulators by Lefstin, Jeffrey A, Yamamoto, Keith R

“…Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global…”
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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA by Luisi, B. F, Xu, W. X, Otwinowski, Z, Freedman, L. P, Yamamoto, K. R, Sigler, P. B

“…Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two…”
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Two signals mediate hormone‐dependent nuclear localization of the glucocorticoid receptor by Picard, D., Yamamoto, K. R.

“…We have detected nuclear localization signals within the 795 amino acid rat glucocorticoid receptor. Using a transient expression assay, we monitored by…”
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Isolation of Hsp90 Mutants by Screening for Decreased Steroid Receptor Function by Bohen, Sean P., Yamamoto, Keith R.

“…The 90-kDa heat shock protein Hsp90 represents a highly conserved strongly expressed gene family; in Saccharomyces cerevisiae, Hsp90 proteins are essential for…”
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Mineralocorticoid and Glucocorticoid Receptor Activities Distinguished by Nonreceptor Factors at a Composite Response Element by Pearce, David, Yamamoto, Keith R.

“…Mineralocorticoid and glucocorticoid hormones elicit distinct physiologic responses, yet the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR)…”
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Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor by Krstic, Marija D., Rogatsky, Inez, Yamamoto, Keith R., Garabedian, Michael J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Steroid Receptor Regulated Transcription of Specific Genes and Gene Networks by Yamamoto, K R

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Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids by IMAI, E, MINER, J. N, MITCHELL, J. A, YAMAMOTO, K. R, GRANNER, D. K

“…The phosphoenolpyruvate carboxykinase (PEPCK) gene encodes the rate-limiting enzyme in gluconeogenesis. Glucocorticoids enhance PEPCK gene expression through a…”
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Roles of SWI1, SWI2, and SWI3 Proteins for Transcriptional Enhancement by Steroid Receptors by Yoshinaga, Steven K., Peterson, Craig L., Herskowitz, Ira, Yamamoto, Keith R.

“…The SWI1, SWI2, and SWI3 proteins, which are required for regulated transcription of numerous yeast genes, were found also to be essential for rat…”
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Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene by SAKAI, D. D, HELMS, S, CARLSTEDT-DUKE, J, GUSTAFSSON, J.-A, ROTTMAN, F. M, YAMAMOTO, K. R

“…We have defined and characterized a region upstream of the bovine prolactin gene that confers repression by glucocorticoids. This 'negative glucocorticoid…”
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Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor by Rusconi, S., Yamamoto, K. R.

“…We have identified two separate regions of the 795 amino acid rat glucocorticoid receptor that interact with hormonal ligands and DNA respectively. The…”
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LEM1, an ATP-Binding-Cassette Transporter, Selectively Modulates the Biological Potency of Steroid Hormones by Kralli, Anastasia, Bohen, Sean P., Yamamoto, Keith R.

“…The rat glucocorticoid receptor confers hormone-dependent transcriptional enhancement when expressed in yeast, thereby enabling the genetic identification of…”
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Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities by SCHENA, M, FREEDMAN, L. P, YAMAMOTO, K. R

“…Mammalian glucocorticoid receptors bind specifically to glucocorticoid response element (GRE) DNA sequences and enhance transcription from GRE-linked promoters…”
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The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element by MINER, J. N, YAMAMOTO, K. R

“…Unrelated factors collaborate at composite response elements to confer novel patterns of transcriptional regulation. For example, AP-1 and glucocorticoid…”
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Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells by Eilers, Martin, Picard, Didier, Yamamoto, Keith R, Bishop, J. Michael

“…The human proto-oncogene myc encodes a nuclear phosphoprotein whose primary biochemical function is still unknown. To facilitate further study of that…”
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Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain by Härd, Torleif, Kellenbach, Edwin, Boelens, Rolf, Maler, Bonnie A., Dahlman, Karin, Freedman, Leonard P., Carlstedt-Duke, Jan, Yamamoto, Keith R., Gustafsson, Jan-Åke, Kaptein, Robert

“…The three-dimensional structure of the DNA-binding domain (DBD) of the glucocorticoid receptor has been determined by nuclear magnetic resonance spectroscopy…”
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Disassembly of Transcriptional Regulatory Complexes by Molecular Chaperones by Freeman, Brian C., Yamamoto, Keith R.

“…Many biological processes are initiated by cooperative assembly of large multicomponent complexes; however, mechanisms for modulating or terminating the…”
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Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA by van Tilborg, M A, Lefstin, J A, Kruiskamp, M, Teuben, J, Boelens, R, Yamamoto, K R, Kaptein, R

“…Two previously isolated mutations in the glucocorticoid receptor DNA-binding domain (DBD), S459A and P493R, have been postulated to mimic DNA-induced…”
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