Search Results - "YAMAGUCHI, Noritaka"

Multiple Roles of Vestigial-Like Family Members in Tumor Development by Yamaguchi, Noritaka

“…Vestigial-like family (VGLL) members are mammalian orthologs of vestigial gene in Drosophila , and they consist of four homologs (VGLL1–4). VGLL members have…”
Get full text

Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6 by Yamaguchi, Noritaka, Nakayama, Yuji, Yamaguchi, Naoto

“…The selective estrogen receptor (ER) modulator tamoxifen inhibits ER signaling in breast cancer cells, and it is used for the treatment of ER-positive breast…”
Get full text

Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway by Hori, Naoto, Okada, Kazuyuki, Takakura, Yuki, Takano, Hiroyuki, Yamaguchi, Naoto, Yamaguchi, Noritaka

“…Vestigial-like 3 (VGLL3) is a member of the VGLL family, whose members serve as cofactors for TEA domain–containing transcription factors (TEADs). TEADs…”
Get full text

Autophagy and proteasomes in thymic epithelial cells: essential bulk protein degradation systems for immune homeostasis maintenance by Yamaguchi, Noritaka, Takakura, Yuki, Akiyama, Taishin

“…The thymus is a central organ that controls T cell development. Thymic epithelial cells (TECs) create a unique microenvironment essential for the…”
Get full text

VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression by Kawamura, Tomohiro, Takehora, Yuki, Hori, Naoto, Takakura, Yuki, Yamaguchi, Naoto, Takano, Hiroyuki, Yamaguchi, Noritaka

“…Vestigial‐like family member 3 (VGLL3) is a member of the VGLL family that serves as cofactors for TEA‐domain transcription factors. Although VGLL3 is involved…”
Get full text

FOXA1 Induces E-Cadherin Expression at the Protein Level via Suppression of Slug in Epithelial Breast Cancer Cells by Anzai, Erina, Hirata, Kensuke, Shibazaki, Misato, Yamada, Chiaki, Morii, Mariko, Honda, Takuya, Yamaguchi, Naoto, Yamaguchi, Noritaka

“…Epithelial-to-mesenchymal transition (EMT) is an important process during embryonic development and tumor progression by which adherent epithelial cells…”
Get full text

The promoting role of lysosome-localized c-Src in autophagosome-lysosome fusion by Suzuki, Ko, Honda, Takuya, Akatsu, Aki, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Src-family kinases (SFKs), such as c-Src, Lyn and Fyn, belong to non-receptor-type tyrosine kinases and play key roles in cell proliferation, adhesion, and…”
Get full text

Golgi Distribution of Lyn to Caveolin- and Giantin-Positive cis-Golgi Membranes and the Caveolin-Negative, TGN46-Positive trans-Golgi Network by Okamoto, Aya, Morinaga, Takao, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Src-family tyrosine kinases, classified as cytosolic enzymes, have crucial roles in regulating cell proliferation, differentiation, migration and cell-shape…”
Get full text

Vestigial‐like family member 3 stimulates cell motility by inducing high‐mobility group AT‐hook 2 expression in cancer cells by Hori, Naoto, Takakura, Yuki, Sugino, Ayumi, Iwasawa, Shuto, Nomizo, Kota, Yamaguchi, Naoto, Takano, Hiroyuki, Yamaguchi, Noritaka

“…Vestigial‐like family member 3 (VGLL3) is a cofactor for TEA domain transcription factors (TEADs). Although VGLL3 is known to be highly expressed and stimulate…”
Get full text

Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling by Nakajo, Haruna, Ishibashi, Kenichi, Aoyama, Kazumasa, Kubota, Sho, Hasegawa, Hitomi, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Protein-tyrosine kinases transmit signals by phosphorylating their substrates in diverse cellular events. The receptor-type tyrosine kinase ErbB4, a member of…”
Get full text

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity by Takakura, Yuki, Machida, Moeka, Terada, Natsumi, Katsumi, Yuka, Kawamura, Seika, Horie, Kenta, Miyauchi, Maki, Ishikawa, Tatsuya, Akiyama, Nobuko, Seki, Takao, Miyao, Takahisa, Hayama, Mio, Endo, Rin, Ishii, Hiroto, Maruyama, Yuya, Hagiwara, Naho, Kobayashi, Tetsuya J., Yamaguchi, Naoto, Takano, Hiroyuki, Akiyama, Taishin, Yamaguchi, Noritaka

“…Autophagy is primarily activated by cellular stress, such as starvation or mitochondrial damage. However, stress-independent autophagy is activated by unclear…”
Get full text

The tyrosine kinase v‐Src modifies cytotoxicities of anticancer drugs targeting cell division by Yuki, Ryuzaburo, Hagino, Mari, Ueno, Sachi, Kuga, Takahisa, Saito, Youhei, Fukumoto, Yasunori, Yamaguchi, Noritaka, Yamaguchi, Naoto, Nakayama, Yuji

“…ABSTRACT v‐Src oncogene causes cell transformation through its strong tyrosine kinase activity. We have revealed that v‐Src‐mediated cell transformation occurs…”
Get full text

Role of Membrane Cholesterol Levels in Activation of Lyn upon Cell Detachment by Morinaga, Takao, Yamaguchi, Noritaka, Nakayama, Yuji, Tagawa, Masatoshi, Yamaguchi, Naoto

“…Cholesterol, a major component of the plasma membrane, determines the physicalproperties of biological membranes and plays a critical role in the assembly of…”
Get full text

Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle by Morii, Mariko, Kubota, Sho, Hasegawa, Chizu, Takeda, Yumi, Kometani, Shiori, Enomoto, Kyoko, Suzuki, Takayuki, Yanase, Sayuri, Sato, Rika, Akatsu, Aki, Hirata, Kensuke, Honda, Takuya, Kuga, Takahisa, Tomonaga, Takeshi, Nakayama, Yuji, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Src-family tyrosine kinases (SFKs) play important roles in a number of signal transduction events during mitosis, such as spindle formation. A relationship has…”
Get full text

Constitutive activation of nuclear factor‐κB is preferentially involved in the proliferation of basal‐like subtype breast cancer cell lines by Yamaguchi, Noritaka, Ito, Taku, Azuma, Sakura, Ito, Emi, Honma, Reiko, Yanagisawa, Yuka, Nishikawa, Akira, Kawamura, Mika, Imai, Jun‐ichi, Watanabe, Shinya, Semba, Kentaro, Inoue, Jun‐ichiro

“…Constitutive nuclear factor (NF)‐κB activation is thought to be involved in survival, invasion, and metastasis in various types of cancers. However, neither…”
Get full text

Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells by Morinaga, Takao, Yanase, Sayuri, Okamoto, Aya, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Src-family kinases, expressed in a wide variety of cell types, are anchored to cellular membranes through posttranslational lipid modifications and involved in…”
Get full text

Fyn Accelerates M Phase Progression by Promoting the Assembly of Mitotic Spindle Microtubules by Okamoto, Mai, Nakayama, Yuji, Kakihana, Ayana, Yuki, Ryuzaburo, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…ABSTRACT The mitotic spindle is the major piece of cellular machinery essential for faithful chromosome segregation. Whereas Fyn, a member of Src‐family…”
Get full text

Protective role for lipid modifications of Src-family kinases against chromosome missegregation by Honda, Takuya, Soeda, Shuhei, Tsuda, Kunihiko, Yamaguchi, Chihiro, Aoyama, Kazumasa, Morinaga, Takao, Yuki, Ryuzaburo, Nakayama, Yuji, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Src-family tyrosine kinases, which are expressed in various cell types, play critical roles in cell signalling at the cytoplasmic side of the plasma membrane…”
Get full text

Activation of Lyn Tyrosine Kinase through Decreased Membrane Cholesterol Levels during a Change in Its Membrane Distribution upon Cell Detachment by Morinaga, Takao, Abe, Kohei, Nakayama, Yuji, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Cellular membranes, which can serve as scaffolds for signal transduction, dynamically change their characteristics upon cell detachment. Src family kinases…”
Get full text

Activation of the Prereplication Complex Is Blocked by Mimosine through Reactive Oxygen Species-activated Ataxia Telangiectasia Mutated (ATM) Protein without DNA Damage by Kubota, Shoichi, Fukumoto, Yasunori, Ishibashi, Kenichi, Soeda, Shuhei, Kubota, Sho, Yuki, Ryuzaburo, Nakayama, Yuji, Aoyama, Kazumasa, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Mimosine is an effective cell synchronization reagent used for arresting cells in late G1 phase. However, the mechanism underlying mimosine-induced G1 cell…”
Get full text