Search Results - "YAMAGUCHI, Naoto"

Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6 by Yamaguchi, Noritaka, Nakayama, Yuji, Yamaguchi, Naoto

“…The selective estrogen receptor (ER) modulator tamoxifen inhibits ER signaling in breast cancer cells, and it is used for the treatment of ER-positive breast…”
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Role of Cyclin B1 Levels in DNA Damage and DNA Damage-Induced Senescence by Nakayama, Yuji, Yamaguchi, Naoto

“…The cyclin B1–Cdk1 complex is a key regulator of mitotic entry. A large number of proteins are phosphorylated by the cyclin B1–Cdk1 complex prior to mitotic…”
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Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway by Hori, Naoto, Okada, Kazuyuki, Takakura, Yuki, Takano, Hiroyuki, Yamaguchi, Naoto, Yamaguchi, Noritaka

“…Vestigial-like 3 (VGLL3) is a member of the VGLL family, whose members serve as cofactors for TEA domain–containing transcription factors (TEADs). TEADs…”
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VGLL3 increases the dependency of cancer cells on de novo nucleotide synthesis through GART expression by Kawamura, Tomohiro, Takehora, Yuki, Hori, Naoto, Takakura, Yuki, Yamaguchi, Naoto, Takano, Hiroyuki, Yamaguchi, Noritaka

“…Vestigial‐like family member 3 (VGLL3) is a member of the VGLL family that serves as cofactors for TEA‐domain transcription factors. Although VGLL3 is involved…”
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FOXA1 Induces E-Cadherin Expression at the Protein Level via Suppression of Slug in Epithelial Breast Cancer Cells by Anzai, Erina, Hirata, Kensuke, Shibazaki, Misato, Yamada, Chiaki, Morii, Mariko, Honda, Takuya, Yamaguchi, Naoto, Yamaguchi, Noritaka

“…Epithelial-to-mesenchymal transition (EMT) is an important process during embryonic development and tumor progression by which adherent epithelial cells…”
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The promoting role of lysosome-localized c-Src in autophagosome-lysosome fusion by Suzuki, Ko, Honda, Takuya, Akatsu, Aki, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Src-family kinases (SFKs), such as c-Src, Lyn and Fyn, belong to non-receptor-type tyrosine kinases and play key roles in cell proliferation, adhesion, and…”
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Nuclear translocation promotes proteasomal degradation of human Rad17 protein through the N-terminal destruction boxes by Fukumoto, Yasunori, Ikeuchi, Masayoshi, Qu, Liang, Hoshino, Tyuji, Yamaguchi, Naoto, Nakayama, Yuji, Ogra, Yasumitsu

“…The ATR pathway is one of the major DNA damage checkpoints, and Rad17 is a DNA-binding protein that is phosphorylated upon DNA damage by ATR kinase. Rad17…”
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In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components ( Humulus lupulus) addressing acne vulgaris by Yamaguchi, Naoto, Satoh-Yamaguchi, Keiko, Ono, Mitsunori

“…Seven naturally derived components from hop plant ( Humulus lupulus L.) extracts were tested for evaluation of biological activities affecting acne vulgaris…”
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Golgi Distribution of Lyn to Caveolin- and Giantin-Positive cis-Golgi Membranes and the Caveolin-Negative, TGN46-Positive trans-Golgi Network by Okamoto, Aya, Morinaga, Takao, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Src-family tyrosine kinases, classified as cytosolic enzymes, have crucial roles in regulating cell proliferation, differentiation, migration and cell-shape…”
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Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells by Kuga, Takahisa, Yamane, Yuka, Hayashi, Soujirou, Taniguchi, Masanari, Yamaguchi, Naoto, Yamagishi, Nobuyuki

“…There are eight human Src-family tyrosine kinases (SFKs). SFK members c-Src, c-Yes, Fyn, and Lyn are expressed in various cancer cells. SFK kinase activity is…”
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The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis by Mishima, Yuta, Miyagi, Satoru, Saraya, Atsunori, Negishi, Masamitsu, Endoh, Mitsuhiro, Endo, Takaho A., Toyoda, Tetsuro, Shinga, Jun, Katsumoto, Takuo, Chiba, Tetsuhiro, Yamaguchi, Naoto, Kitabayashi, Issay, Koseki, Haruhiko, Iwama, Atsushi

“…The histone acetyltransferases (HATs) of the MYST family include TIP60, HBO1, MOZ/MORF, and MOF and function in multisubunit protein complexes…”
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The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1 by Horiuchi, Maria, Kuga, Takahisa, Saito, Youhei, Nagano, Maiko, Adachi, Jun, Tomonaga, Takeshi, Yamaguchi, Naoto, Nakayama, Yuji

“…The nonreceptor tyrosine kinase v-Src is an oncogene first identified in Rous sarcoma virus. The oncogenic effects of v-Src have been intensively studied;…”
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Vestigial‐like family member 3 stimulates cell motility by inducing high‐mobility group AT‐hook 2 expression in cancer cells by Hori, Naoto, Takakura, Yuki, Sugino, Ayumi, Iwasawa, Shuto, Nomizo, Kota, Yamaguchi, Naoto, Takano, Hiroyuki, Yamaguchi, Noritaka

“…Vestigial‐like family member 3 (VGLL3) is a cofactor for TEA domain transcription factors (TEADs). Although VGLL3 is known to be highly expressed and stimulate…”
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Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling by Nakajo, Haruna, Ishibashi, Kenichi, Aoyama, Kazumasa, Kubota, Sho, Hasegawa, Hitomi, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Protein-tyrosine kinases transmit signals by phosphorylating their substrates in diverse cellular events. The receptor-type tyrosine kinase ErbB4, a member of…”
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Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17 by Fukumoto, Yasunori, Takahashi, Kazuaki, Suzuki, Noriyuki, Ogra, Yasumitsu, Nakayama, Yuji, Yamaguchi, Naoto

“…An interaction between the Rad17-RFC2-5 and 9-1-1 complexes is essential for ATR-Chk1 signaling, which is one of the major DNA damage checkpoints. Recently, we…”
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Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis by Nakayama, Yuji, Soeda, Shuhei, Ikeuchi, Masayoshi, Kakae, Keiko, Yamaguchi, Naoto

“…v-Src, an oncogene found in Rous sarcoma virus, is a constitutively active variant of c-Src. Activation of Src is observed frequently in colorectal and breast…”
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Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity by Takakura, Yuki, Machida, Moeka, Terada, Natsumi, Katsumi, Yuka, Kawamura, Seika, Horie, Kenta, Miyauchi, Maki, Ishikawa, Tatsuya, Akiyama, Nobuko, Seki, Takao, Miyao, Takahisa, Hayama, Mio, Endo, Rin, Ishii, Hiroto, Maruyama, Yuya, Hagiwara, Naho, Kobayashi, Tetsuya J., Yamaguchi, Naoto, Takano, Hiroyuki, Akiyama, Taishin, Yamaguchi, Noritaka

“…Autophagy is primarily activated by cellular stress, such as starvation or mitochondrial damage. However, stress-independent autophagy is activated by unclear…”
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Cancer-Type OATP1B3 mRNA in Extracellular Vesicles as a Promising Candidate for a Serum-Based Colorectal Cancer Biomarker by Morio, Hanae, Sun, Yuchen, Harada, Manami, Ide, Hideyuki, Shimozato, Osamu, Zhou, Xujia, Higashi, Kenjirou, Yuki, Ryuzaburo, Yamaguchi, Naoto, Hofbauer, Josefina Piñón, Guttmann-Gruber, Christina, Anzai, Naohiko, Akita, Hidetaka, Chiba, Kan, Furihata, Tomomi

“…Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA is a variant isoform of the liver-type OATP1B3. Because Ct-OATP1B3 mRNA shows an…”
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The tyrosine kinase v‐Src modifies cytotoxicities of anticancer drugs targeting cell division by Yuki, Ryuzaburo, Hagino, Mari, Ueno, Sachi, Kuga, Takahisa, Saito, Youhei, Fukumoto, Yasunori, Yamaguchi, Noritaka, Yamaguchi, Naoto, Nakayama, Yuji

“…ABSTRACT v‐Src oncogene causes cell transformation through its strong tyrosine kinase activity. We have revealed that v‐Src‐mediated cell transformation occurs…”
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Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain by Sato, Izumi, Obata, Yuuki, Kasahara, Kousuke, Nakayama, Yuji, Fukumoto, Yasunori, Yamasaki, Takahito, Yokoyama, Kazunari K, Saito, Takashi, Yamaguchi, Naoto

“…Src-family tyrosine kinases (SFKs), which participate in a variety of signal transduction events, are known to localize to the cytoplasmic face of the plasma…”
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