Search Results - "YAMAGUCHI, KOSUKE"

Epigenetic modifications and reprogramming in paternal pronucleus: sperm, preimplantation embryo, and beyond by Okada, Yuki, Yamaguchi, Kosuke

“…Pronuclear/zygotic stage is the very first stage of life. In this period, paternal pronucleus undergoes massive chromatin remodeling called “paternal…”
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Utilization of Ni as a Non-Noble-Metal Co-catalyst for Ceria-Supported Rhenium Oxide in Combination of Deoxydehydration and Hydrogenation of Vicinal Diols by Yamaguchi, Kosuke, Nakagawa, Yoshinao, Li, Congcong, Yabushita, Mizuho, Tomishige, Keiichi

“…Removal of vicinal diols by combination of deoxydehydration and hydrogenation (DODH + HG) was carried out over the mixture of ReO x /CeO2 and CeO2-supported…”
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Re-evaluating the Localization of Sperm-Retained Histones Revealed the Modification-Dependent Accumulation in Specific Genome Regions by Yamaguchi, Kosuke, Hada, Masashi, Fukuda, Yuko, Inoue, Erina, Makino, Yoshinori, Katou, Yuki, Shirahige, Katsuhiko, Okada, Yuki

“…The question of whether retained histones in the sperm genome localize to gene-coding regions or gene deserts has been debated for years. Previous…”
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Vascular endothelial growth factor signaling in VE-cadherin expression and tube-like formation by rheumatoid arthritic synovial fibroblast-like cells by Yamaguchi, Kosuke, Sudo, Haruka, Imai, Kazushi

“…An increase in the vasculature is one of most representative changes in the synovial tissue of joints in rheumatoid arthritis (RA) and is closely associated…”
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Adsorption of Keggin-Type Polyoxometalates on Rh Metal Particles under Reductive Conditions by Nakagawa, Yoshinao, Kuwata, Ayaka, Yamaguchi, Kosuke, Tamura, Masazumi, Yabushita, Mizuho, Tomishige, Keiichi

“…The adsorption of POMs on Rh/SiO2 in water solvent under strongly reductive conditions was investigated. Aqueous solutions of α-Keggin type silicotungstate and…”
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Structural basis for activation of DNMT1 by Kikuchi, Amika, Onoda, Hiroki, Yamaguchi, Kosuke, Kori, Satomi, Matsuzawa, Shun, Chiba, Yoshie, Tanimoto, Shota, Yoshimi, Sae, Sato, Hiroki, Yamagata, Atsushi, Shirouzu, Mikako, Adachi, Naruhiko, Sharif, Jafar, Koseki, Haruhiko, Nishiyama, Atsuya, Nakanishi, Makoto, Defossez, Pierre-Antoine, Arita, Kyohei

“…DNMT1 is an essential enzyme that maintains genomic DNA methylation, and its function is regulated by mechanisms that are not yet fully understood. Here, we…”
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Histone functions as a cell-surface receptor for AGEs by Itakura, Masanori, Yamaguchi, Kosuke, Kitazawa, Roma, Lim, Sei-Young, Anan, Yusuke, Yoshitake, Jun, Shibata, Takahiro, Negishi, Lumi, Sugawa, Hikari, Nagai, Ryoji, Uchida, Koji

“…Reducing sugars can covalently react with proteins to generate a heterogeneous and complex group of compounds called advanced glycation end products (AGEs)…”
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Antibody-Dependent Cellular Cytotoxicity Mediated by Cetuximab against Lung Cancer Cell Lines by KURAI, Jun, CHIKUMI, Hiroki, NAKAMOTO, Masaki, BURIOKA, Naoto, SHIMIZU, Eiji, HASHIMOTO, Kiyoshi, YAMAGUCHI, Kosuke, YAMASAKI, Akira, SAKO, Takanori, TOUGE, Hirokazu, MAKINO, Haruhiko, TAKATA, Miyako, MIYATA, Masanori

“…Purpose: Epidermal growth factor receptor (EGFR) is commonly overexpressed in lung cancer. Cetuximab is a chimeric mouse-human antibody targeted against EGFR…”
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Identification of a variant-specific phosphorylation of TH2A during spermiogenesis by Hada, Masashi, Masuda, Koji, Yamaguchi, Kosuke, Shirahige, Katsuhiko, Okada, Yuki

“…Tissue-specific histone variant incorporation into chromatin plays dynamic and important roles in tissue development. Testis is one such tissue, and a number…”
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Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells by Yamaguchi, Kosuke, Chen, Xiaoying, Rodgers, Brianna, Miura, Fumihito, Bashtrykov, Pavel, Bonhomme, Frédéric, Salinas-Luypaert, Catalina, Haxholli, Deis, Gutekunst, Nicole, Aygenli, Bihter Özdemir, Ferry, Laure, Kirsh, Olivier, Laisné, Marthe, Scelfo, Andrea, Ugur, Enes, Arimondo, Paola B., Leonhardt, Heinrich, Kanemaki, Masato T., Bartke, Till, Fachinetti, Daniele, Jeltsch, Albert, Ito, Takashi, Defossez, Pierre-Antoine

“…DNA methylation is an essential epigenetic chromatin modification, and its maintenance in mammals requires the protein UHRF1. It is yet unclear if UHRF1…”
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Large-Scale Chromatin Rearrangements in Cancer by Yamaguchi, Kosuke, Chen, Xiaoying, Oji, Asami, Hiratani, Ichiro, Defossez, Pierre-Antoine

“…Epigenetic abnormalities are extremely widespread in cancer. Some of them are mere consequences of transformation, but some actively contribute to cancer…”
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Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins by Anan, Yusuke, Itakura, Masanori, Shimoda, Tatsuya, Yamaguchi, Kosuke, Lu, Peng, Nagata, Koji, Dong, Jinhua, Ueda, Hiroshi, Uchida, Koji

“…Anti-DNA antibodies (Abs), serological hallmarks of systemic lupus erythematosus (SLE) and markers for diagnosis and disease activity, show a specificity for…”
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DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair by Yanai, Masaaki, Makino, Haruhiko, Ping, Bingqiong, Takeda, Kenichi, Tanaka, Natsumi, Sakamoto, Tomohiro, Yamaguchi, Kosuke, Kodani, Masahiro, Yamasaki, Akira, Igishi, Tadashi, Shimizu, Eiji

“…[ABSTRACT] [Background] DNA double-strand breaks (DSBs) are the most cytotoxic form of DNA damage and are induced by ionizing radiation and specific…”
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Bronchodilator Reversibility Occurring during the Acute Phase of Paragonimiasis westermani Infection by Harada, Tomoya, Kawasaki, Yuji, Tsukada, Akira, Osawa, Yoichi, Takami, Hiroki, Yamaguchi, Kosuke, Kurai, Jun, Yamasaki, Akira, Shimizu, Eiji

“…A 43-year-old woman was referred to our hospital with peripheral blood hypereosinophilia and abnormal chest X-ray findings. Her pleural effusion revealed…”
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Pembrolizumab-induced asthma exacerbation with hypereosinophilia and elevated interleukin-5 in endometrial cancer: A case report by Harada, Tomoya, Uetani, Naoki, Inui, Genki, Ishikawa, Hiroki, Funaki, Yoshihiro, Takata, Miki, Okazaki, Ryota, Yamaguchi, Kosuke, Morita, Masato, Kitatani, Shin, Yamasaki, Akira

“…Pembrolizumab is an anti-programmed cell death-1 (PD-1) antibody used to treat various cancer types. Treatments with such immune checkpoint inhibitors cause…”
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Diagnostic and prognostic impact of serum‐soluble UL16‐binding protein 2 in lung cancer patients by Yamaguchi, Kosuke, Chikumi, Hiroki, Shimizu, Asuka, Takata, Miyako, Kinoshita, Naoki, Hashimoto, Kiyoshi, Nakamoto, Masaki, Matsunaga, Shinji, Kurai, Jun, Miyake, Naomi, Matsumoto, Shingo, Watanabe, Masanari, Yamasaki, Akira, Igishi, Tadashi, Burioka, Naoto, Shimizu, Eiji

“…UL16‐binding protein 2 (ULBP2) is one of the ligands for NKG2D (NKG2DL). ULBP2 expression is induced in transformed cells and is recognized by immune effector…”
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Effect of Cetuximab and EGFR Small Interfering RNA Combination Treatment in NSCLC Cell Lines with Wild Type EGFR and Use of KRAS as a Possible Biomarker for Treatment Responsiveness by Miyake, Naomi, Chikumi, Hiroki, Yamaguchi, Kosuke, Takata, Miyako, Takata, Miki, Okada, Kensaku, Kitaura, Tsuyoshi, Nakamoto, Masaki, Yamasaki, Akira

“…The epidermal growth factor receptor (EGFR) is a therapeutic target for patients with non-small cell lung cancer (NSCLC). Cetuximab is an anti-EGFR monoclonal…”
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Photocatalytic decomposition of 2-propanol in air by mechanical mixtures of TiO2 crystalline particles and silicalite adsorbent : The complete conversion of organic molecules strongly adsorbed within zeolitic channels by YAMAGUCHI, Kosuke, INUMARU, Kei, OUMI, Yasunori, SANO, Tsuneji, YAMANAKA, Shoji

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Evaluation of antigen‐positive toxin‐negative enzyme immunoassay results for the diagnosis of toxigenic Clostridium difficile infection by Akamatsu, Yukinobu, Morishita, Shota, Chikumi, Hiroki, Okamoto, Ryo, Okada, Kensaku, Kitaura, Tsuyoshi, Miyake, Naomi, Yamaguchi, Kosuke, Nakamoto, Masaki, Shimohiro, Hisashi, Takata, Miyako, Yamasaki, Akira, Burioka, Naoto, Shimizu, Eiji

“…Clostridium difficile (C. difficile)‐associated diarrhea (CDAD) is a challenging nosocomial infectious disease. C. DIFF Quik Chek Complete assay is widely used…”
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A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers by Yamaguchi, Kosuke, Iglesias-Bartolomé, Ramiro, Wang, Zhiyong, Callejas-Valera, Juan Luis, Amornphimoltham, Panomwat, Molinolo, Alfredo A, Cohen, Ezra E, Califano, Joseph A, Lippman, Scott M, Luo, Ji, Gutkind, J Silvio

“…mTOR inhibition has emerged as a promising strategy for head and neck squamous cell carcinomas (HNSCC) treatment. However, most targeted therapies ultimately…”
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