Search Results - "YAKSH, T. L."

Spinal glial TLR4‐mediated nociception and production of prostaglandin E2 and TNF by Saito, O, Svensson, CI, Buczynski, MW, Wegner, K, Hua, X‐Y, Codeluppi, S, Schaloske, RH, Deems, RA, Dennis, EA, Yaksh, TL

“…Background and purpose:  Toll‐like receptor 4 (TLR4) expressed on spinal microglia and astrocytes has been suggested to play an important role in the…”
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Pharmacology and mechanisms of opioid analgesic activity by YAKSH, T. L.

“…Opiates by an action at specific receptors can induce a highly selective alteration in the response of humans and animals to strong and otherwise aversive…”
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Quantitative assessment of tactile allodynia in the rat paw by Chaplan, S R, Bach, F W, Pogrel, J W, Chung, J M, Yaksh, T L

“…We applied and validated a quantitative allodynia assessment technique, using a recently developed rat surgical neuropathy model wherein nocifensive behaviors…”
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The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation by Park, H.J., Sandor, K., McQueen, J., Woller, S.A., Svensson, C.I., Corr, M., Yaksh, T.L.

“…Background Glucose‐6‐phosphate isomerase and collagen type II antibody‐induced arthritis models (K/BxN and CAIA, respectively) have an inflammatory and a…”
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Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition by Malmberg, A. B., Yaksh, T. L.

“…Inhibition of cyclooxygenase by nonsteroidal anti-inflammatory drugs (NSAIDs) in the periphery is commonly accepted as the primary mechanism by which these…”
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Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat by Malmberg, A B, Yaksh, T L

“…Subcutaneous injection of formalin into the dorsal surface of the hindpaw evoked a two-phased flinching (phase 1:0-9 min; phase 2: 10-60 min) of the injected…”
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Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia by Fuchigami, T, Kakinohana, O, Hefferan, M.P, Lukacova, N, Marsala, S, Platoshyn, O, Sugahara, K, Yaksh, T.L, Marsala, M

“…Abstract Background: spasticity and rigidity are serious complications associated with spinal traumatic or ischemic injury. Clinical studies show that…”
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Spinal release of tumour necrosis factor activates c-Jun N-terminal kinase and mediates inflammation-induced hypersensitivity by Bas, D.B., Abdelmoaty, S., Sandor, K., Codeluppi, S., Fitzsimmons, B., Steinauer, J., Hua, X.Y., Yaksh, T.L., Svensson, C.I.

“…Background Mounting evidence points to individual contributions of tumour necrosis factor‐alpha (TNF) and the c‐Jun N‐terminal kinase (JNK) pathway to the…”
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Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: A qualitative and quantitative electrophysiological and histopathological study by Kakinohana, O., Hefferan, M.P., Nakamura, S., Kakinohana, M., Galik, J., Tomori, Z., Marsala, J., Yaksh, T.L., Marsala, M.

“…Transient spinal cord ischemia may lead to a progressive degeneration of spinal interneurons and subsequently to increased hind limb motor tone. In the present…”
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The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat by Hwang, J H, Yaksh, T L

“…This study evaluated the effects of spinal gamma-aminobutyric acid (GABA) receptor agonists on the tactile allodynia observed in rats with ligation of the…”
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Spinal N -methyl- d -aspartate receptors and nociception-evoked release of primary afferent substance P by Nazarian, A, Gu, G, Gracias, N.G, Wilkinson, K, Hua, X.-Y, Vasko, M.R, Yaksh, T.L

“…Abstract Dorsal horn N -methyl- d -aspartate (NMDA) receptors contribute significantly to spinal nociceptive processing through an effect postsynaptic to…”
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Role of voltage-dependent calcium channel subtypes in experimental tactile allodynia by Chaplan, S R, Pogrel, J W, Yaksh, T L

“…Peripheral nerve lesions can result in exaggerated pain responses to low intensity mechanical stimuli (tactile allodynia). In the present work, the…”
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Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism by Christianson, C.A, Fitzsimmons, B.L, Shim, J.-H, Agrawal, A, Cohen, S.M, Hua, X.-Y, Yaksh, T.L

“…Abstract Matrix metalloproteinases (MMPs) have been implicated in the modulation of synaptic plasticity, glial activation, and long-term potentiation in the…”
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Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model by Dirig, D M, Yaksh, T L

“…Both gamma-aminobutyric acid (GABA)A and GABAB receptor subtypes have been implicated in spinally mediated antinociception in acute pain models. In the current…”
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Concentration-effect relationship of intravenous lidocaine on the allodynia of Complex Regional Pain Syndrome types I and II by WALLACE, M. S, RIDGEWAY, B. M, LEUNG, A. Y, GERAYLI, A, YAKSH, T. L

“…Several lines of evidence suggest that neuropathic pain (including Complex Regional Pain Syndrome [CRPS] I and CRPS II) is mediated in part by an increase in…”
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Comparison of the antinociceptive effects of Pre- and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat by YAMAMOTO, T, YAKSH, T. L

“…Current thinking emphasizes that protracted small afferent input can evoke mechanisms that mediate a significant potentiation of spinal nociceptive processing…”
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Neuronal Nitric Oxide Synthase mRNA Upregulation in Rat Sensory Neurons after Spinal Nerve Ligation: Lack of a Role in Allodynia Development by Luo, Z. David, Chaplan, S. R, Scott, B. P, Cizkova, D, Calcutt, N. A, Yaksh, T. L

“…Pharmacological evidence suggests a functional role for spinal nitric oxide (NO) in the modulation of thermal and/or inflammatory hyperalgesia. To assess the…”
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Spinal distribution and metabolism of 2′- O-(2-methoxyethyl)-modified oligonucleotides after intrathecal administration in rats by Butler, M., Hayes, C.S., Chappell, A., Murray, S.F., Yaksh, T.L., Hua, X.-Y.

“…Intrathecal (IT) delivery of antisense oligodeoxynucleotides (ASO) has been used to study the function of specific gene products in spinal nociception…”
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Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists by Yaksh, T L, Pogrel, J W, Lee, Y W, Chaplan, S R

“…After nerve injury, a sympathetically dependent allodynia may be observed. Spinal alpha-2 agonists inhibit preganglionic neurons. The nature of the effect of…”
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Spinal phospholipase A2 in inflammatory hyperalgesia : Role of the small, secretory phospholipase A2 by SVENSSON, C. I, LUCAS, K. K, HUA, X.-Y, POWELL, H. C, DENNIS, E. A, YAKSH, T. L

“…Current work emphasizes that peripheral tissue injury and inflammation results in a heightened sensitivity to subsequent noxious input (hyperalgesia) that is…”
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