Search Results - "YAFFE, Michael B"

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks by Lee, Michael J., Ye, Albert S., Gardino, Alexandra K., Heijink, Anne Margriet, Sorger, Peter K., MacBeath, Gavin, Yaffe, Michael B.

“…Crosstalk and complexity within signaling pathways and their perturbation by oncogenes limit component-by-component approaches to understanding human disease…”
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Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series by Wang, Janice, Hajizadeh, Negin, Moore, Ernest E., McIntyre, Robert C., Moore, Peter K., Veress, Livia A., Yaffe, Michael B., Moore, Hunter B., Barrett, Christopher D.

“…A prothrombotic coagulopathy is commonly found in critically ill COVID‐19 patients with acute respiratory distress syndrome (ARDS). A unique feature of…”
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Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response by Reinhardt, H. Christian, Yaffe, Michael B.

“…Key Points Coordinated cell cycle progression is a complex challenge for eukaryotic cells. In response to DNA damage, a plethora of molecular signals must be…”
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Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks by van de Kooij, Bert, Kruswick, Alex, van Attikum, Haico, Yaffe, Michael B.

“…DNA double-strand breaks (DSB) are repaired by multiple distinct pathways, with outcomes ranging from error-free repair to mutagenesis and genomic loss…”
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BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage by Lam, Fred C., Kong, Yi Wen, Huang, Qiuying, Vu Han, Tu-Lan, Maffa, Amanda D., Kasper, Ekkehard M., Yaffe, Michael B.

“…Proper chromatin function and maintenance of genomic stability depends on spatiotemporal coordination between the transcription and replication machinery. Loss…”
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Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles by Lam, Fred C., Morton, Stephen W., Wyckoff, Jeffrey, Vu Han, Tu-Lan, Hwang, Mun Kyung, Maffa, Amanda, Balkanska-Sinclair, Elena, Yaffe, Michael B, Floyd, Scott R, Hammond, Paula T

“…Effective treatment for glioblastoma (GBM) is limited by the presence of the blood–brain barrier (BBB) and rapid resistance to single agent therapies. To…”
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Computational approaches for analyzing information flow in biological networks by Kholodenko, Boris, Yaffe, Michael B, Kolch, Walter

“…The advancements in "omics" (proteomics, genomics, lipidomics, and metabolomics) technologies have yielded large inventories of genes, transcripts, proteins,…”
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Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma by Braun, Christian J., Stanciu, Monica, Boutz, Paul L., Patterson, Jesse C., Calligaris, David, Higuchi, Fumi, Neupane, Rachit, Fenoglio, Silvia, Cahill, Daniel P., Wakimoto, Hiroaki, Agar, Nathalie Y.R., Yaffe, Michael B., Sharp, Phillip A., Hemann, Michael T., Lees, Jacqueline A.

“…Glioblastoma (GBM) is a devastating malignancy with few therapeutic options. We identify PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or…”
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Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation by Lunt, Sophia Y., Muralidhar, Vinayak, Hosios, Aaron M., Israelsen, William J., Gui, Dan Y., Newhouse, Lauren, Ogrodzinski, Martin, Hecht, Vivian, Xu, Kali, Acevedo, Paula N. Marín, Hollern, Daniel P., Bellinger, Gary, Dayton, Talya L., Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Vander Heiden, Matthew G.

“…Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms on tumor cells has been extensively studied, but whether PKM2 is…”
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MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis by Suarez-Lopez, Lucia, Sriram, Ganapathy, Kong, Yi Wen, Morandell, Sandra, Merrick, Karl A., Hernandez, Yuliana, Haigis, Kevin M., Yaffe, Michael B.

“…Chronic inflammation is a major risk factor for colorectal cancer. The p38/MAPKAP Kinase 2 (MK2) kinase axis controls the synthesis of proinflammatory…”
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The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling by Hsu, Peggy P., Kang, Seong A., Rameseder, Jonathan, Zhang, Yi, Ottina, Kathleen A., Lim, Daniel, Peterson, Timothy R., Choi, Yongmun, Gray, Nathanael S., Yaffe, Michael B., Marto, Jarrod A., Sabatini, David M.

“…The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse…”
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Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis by Banko, Max R., Allen, Jasmina J., Schaffer, Bethany E., Wilker, Erik W., Tsou, Peiling, White, Jamie L., Villén, Judit, Wang, Beatrice, Kim, Sara R., Sakamoto, Kei, Gygi, Steven P., Cantley, Lewis C., Yaffe, Michael B., Shokat, Kevan M., Brunet, Anne

“…The energy-sensing AMP-activated protein kinase (AMPK) is activated by low nutrient levels. Functions of AMPK, other than its role in cellular metabolism, are…”
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RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly by Huen, Michael S.Y., Grant, Robert, Manke, Isaac, Minn, Kay, Yu, Xiaochun, Yaffe, Michael B., Chen, Junjie

“…DNA-damage signaling utilizes a multitude of posttranslational modifiers as molecular switches to regulate cell-cycle checkpoints, DNA repair, cellular…”
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TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal by Peerani, Raheem, Yaffe, Michael B, Rao, Balaji M, Dembowy, Joanna, Varelas, Xaralabos, Samavarchi-Tehrani, Payman, Sakuma, Rui, Zandstra, Peter W, Wrana, Jeffrey L

“…Transforming growth fazctor-β (TGFβ) family members regulate many developmental and pathological events through Smad transcriptional modulators. How nuclear…”
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How do 14-3-3 proteins work? – Gatekeeper phosphorylation and the molecular anvil hypothesis by Yaffe, Michael B

“…14-3-3 proteins were the first signaling molecules to be identified as discrete phosphoserine/threonine binding modules. This family of proteins, which…”
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Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition by Shaul, Yoav D., Freinkman, Elizaveta, Comb, William C., Cantor, Jason R., Tam, Wai Leong, Thiru, Prathapan, Kim, Dohoon, Kanarek, Naama, Pacold, Michael E., Chen, Walter W., Bierie, Brian, Possemato, Richard, Reinhardt, Ferenc, Weinberg, Robert A., Yaffe, Michael B., Sabatini, David M.

“…It is increasingly appreciated that oncogenic transformation alters cellular metabolism to facilitate cell proliferation, but less is known about the metabolic…”
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A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways by Morton, Stephen W, Lee, Michael J, Deng, Zhou J, Dreaden, Erik C, Siouve, Elise, Shopsowitz, Kevin E, Shah, Nisarg J, Yaffe, Michael B, Hammond, Paula T

“…Exposure to the EGFR (epidermal growth factor receptor) inhibitor erlotinib promotes the dynamic rewiring of apoptotic pathways, which sensitizes cells within…”
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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery by Macůrek, Libor, Lindqvist, Arne, Lim, Dan, Lampson, Michael A., Klompmaker, Rob, Freire, Raimundo, Clouin, Christophe, Taylor, Stephen S., Yaffe, Michael B., Medema, René H.

“…Cell division: PLK1 and aurora A at the checkpoint Polo-like kinase-1 (PLK1) is an essential mitotic kinase regulating multiple aspects of the cell division…”
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Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells by Segal, Brahm H., Giridharan, Thejaswini, Suzuki, Sora, Khan, ANM Nazmul H., Zsiros, Emese, Emmons, Tiffany R., Yaffe, Michael B., Gankema, Angela A. F., Hoogeboom, Mark, Goetschalckx, Ines, Matlung, Hanke L., Kuijpers, Taco W.

“…Summary Neutrophils sense microbes and host inflammatory mediators, and traffic to sites of infection where they direct a broad armamentarium of antimicrobial…”
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Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis by Dong, Ting, Hu, Guangan, Fan, Zhongqi, Wang, Huirui, Gao, Yinghui, Wang, Sisi, Xu, Hao, Yaffe, Michael B., Vander Heiden, Matthew G., Lv, Guoyue, Chen, Jianzhu

“…Kupffer cells are liver resident macrophages and play critical role in fatty liver disease, yet the underlying mechanisms remain unclear. Here, we show that…”
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