Search Results - "Y.L. Tham, Christine"

Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease by Tan-Garcia, Alfonso, Wai, Lu-En, Zheng, Dahai, Ceccarello, Erica, Jo, Juandy, Banu, Nasirah, Khakpoor, Atefeh, Chia, Adeline, Y.L. Tham, Christine, Tan, Anthony T, Hong, Michelle, Keng, Choong Tat, Rivino, Laura, Tan, Kai Chah, Hoe Lee, Kang, Lim, Seng Gee, Newell, Evan W, Pavelka, Norman, Chen, Jinmiao, Ginhoux, Florent, Chen, Qingfeng, Bertoletti, Antonio, Dutertre, Charles-Antoine

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SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls by Le Bert, Nina, Tan, Anthony T., Kunasegaran, Kamini, Tham, Christine Y. L., Hafezi, Morteza, Chia, Adeline, Chng, Melissa Hui Yen, Lin, Meiyin, Tan, Nicole, Linster, Martin, Chia, Wan Ni, Chen, Mark I-Cheng, Wang, Lin-Fa, Ooi, Eng Eong, Kalimuddin, Shirin, Tambyah, Paul Anantharajah, Low, Jenny Guek-Hong, Tan, Yee-Joo, Bertoletti, Antonio

“…Memory T cells induced by previous pathogens can shape susceptibility to, and the clinical severity of, subsequent infections 1 . Little is known about the…”
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Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients by Tan, Anthony T., Linster, Martin, Tan, Chee Wah, Le Bert, Nina, Chia, Wan Ni, Kunasegaran, Kamini, Zhuang, Yan, Tham, Christine Y.L., Chia, Adeline, Smith, Gavin J.D., Young, Barnaby, Kalimuddin, Shirin, Low, Jenny G.H., Lye, David, Wang, Lin-Fa, Bertoletti, Antonio

“…Virus-specific humoral and cellular immunity act synergistically to protect the host from viral infection. We interrogate the dynamic changes of virological…”
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Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection by Le Bert, Nina, Clapham, Hannah E, Tan, Anthony T, Chia, Wan Ni, Tham, Christine Y L, Lim, Jane M, Kunasegaran, Kamini, Tan, Linda Wei Lin, Dutertre, Charles-Antoine, Shankar, Nivedita, Lim, Joey M E, Sun, Louisa Jin, Zahari, Marina, Tun, Zaw Myo, Kumar, Vishakha, Lim, Beng Lee, Lim, Siew Hoon, Chia, Adeline, Tan, Yee-Joo, Tambyah, Paul Anantharajah, Kalimuddin, Shirin, Lye, David, Low, Jenny G H, Wang, Lin-Fa, Wan, Wei Yee, Hsu, Li Yang, Bertoletti, Antonio, Tam, Clarence C

“…The efficacy of virus-specific T cells in clearing pathogens involves a fine balance between antiviral and inflammatory features. SARS-CoV-2-specific T cells…”
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An accelerated rabies vaccine schedule based on toll-like receptor 3 (TLR3) agonist PIKA adjuvant augments rabies virus specific antibody and T cell response in healthy adult volunteers by Wijaya, Limin, Tham, Christine Y.L, Chan, Yvonne F.Z, Wong, Abigail W.L, Li, L.T, Wang, Lin-Fa, Bertoletti, Antonio, Low, Jenny G

“…Abstract Background Rabies is a fatal disease where post-exposure prophylaxis (PEP) is crucial in preventing infection. However, deaths even after appropriate…”
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Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy by Tan-Garcia, Alfonso, Lai, Fritz, Yeong, Joe Poh Sheng, Irac, Sergio E., Ng, Pei Y., Msallam, Rasha, Lim, Jeffrey Chun Tatt, Wai, Lu-En, Tham, Christine Y.L., Choo, Su P., Lim, Tony, Young, Dan Y., D'Ambrosio, Roberta, Degasperi, Elisabetta, Perbellini, Riccardo, Newell, Evan, Le Bert, Nina, Ginhoux, Florent, Bertoletti, Antonio, Chen, Qingfeng, Dutertre, Charles-Antoine

“…Chronic liver inflammation leads to fibrosis and cirrhosis and is associated with an accumulation of intrahepatic TNFα-secreting CD206+ macrophages, which may…”
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Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes by Tham, Christine Y.L., Kah, Janine, Tan, Anthony T., Volz, Tassilo, Chia, Adeline, Giersch, Katja, Ladiges, Yvonne, Loglio, Alessandro, Borghi, Marta, Sureau, Camille, Lampertico, Pietro, Lütgehetmann, Marc, Dandri, Maura, Bertoletti, Antonio

“…Hepatitis delta virus (HDV) requires hepatitis B virus (HBV) to complete its infection cycle and causes severe hepatitis, with limited therapeutic options. To…”
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Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 by Swadling, Leo, Diniz, Mariana O., Schmidt, Nathalie M., Amin, Oliver E., Chandran, Aneesh, Shaw, Emily, Pade, Corinna, Gibbons, Joseph M., Le Bert, Nina, Tan, Anthony T., Jeffery-Smith, Anna, Tan, Cedric C. S., Tham, Christine Y. L., Kucykowicz, Stephanie, Aidoo-Micah, Gloryanne, Rosenheim, Joshua, Davies, Jessica, Johnson, Marina, Jensen, Melanie P., Joy, George, McCoy, Laura E., Valdes, Ana M., Chain, Benjamin M., Goldblatt, David, Altmann, Daniel M., Boyton, Rosemary J., Manisty, Charlotte, Treibel, Thomas A., Moon, James C., van Dorp, Lucy, Balloux, Francois, McKnight, Áine, Noursadeghi, Mahdad, Bertoletti, Antonio, Maini, Mala K.

“…Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity,…”
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Safety and effectiveness of up to 3 years’ bulevirtide monotherapy in patients with HDV-related cirrhosis by Loglio, Alessandro, Ferenci, Peter, Uceda Renteria, Sara Colonia, Tham, Christine Y.L., Scholtes, Caroline, Holzmann, Heidemarie, van Bömmel, Florian, Borghi, Marta, Perbellini, Riccardo, Rimondi, Alessandro, Farina, Elisa, Trombetta, Elena, Manunta, Maria, Porretti, Laura, Prati, Daniele, Ceriotti, Ferruccio, Zoulim, Fabien, Bertoletti, Antonio, Lampertico, Pietro

“…The entry inhibitor bulevirtide (BLV) received conditional approval from the EMA in July 2020 for the treatment of adult patients with compensated chronic…”
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Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study by Chia, Wan Ni, Zhu, Feng, Ong, Sean Wei Xiang, Young, Barnaby Edward, Fong, Siew-Wai, Le Bert, Nina, Tan, Chee Wah, Tiu, Charles, Zhang, Jinyan, Tan, Seow Yen, Pada, Surinder, Chan, Yi-Hao, Tham, Christine Y L, Kunasegaran, Kamini, Chen, Mark I-C, Low, Jenny G H, Leo, Yee-Sin, Renia, Laurent, Bertoletti, Antonio, Ng, Lisa F P, Lye, David Chien, Wang, Lin-Fa

“…Studies have found different waning rates of neutralising antibodies compared with binding antibodies against SARS-CoV-2. The impact of neutralising antibody…”
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Excellent safety and effectiveness of high-dose myrcludex-B monotherapy administered for 48 weeks in HDV-related compensated cirrhosis: A case report of 3 patients by Loglio, Alessandro, Ferenci, Peter, Uceda Renteria, Sara Colonia, Tham, Christine Y.L., van Bömmel, Florian, Borghi, Marta, Holzmann, Heidemarie, Perbellini, Riccardo, Trombetta, Elena, Giovanelli, Silvia, Greco, Letizia, Porretti, Laura, Prati, Daniele, Ceriotti, Ferruccio, Lunghi, Giovanna, Bertoletti, Antonio, Lampertico, Pietro

“…Short-term administration of the entry inhibitor myrcludex-B (MyrB) has been shown to be safe and effective in phase II studies in patients coinfected with…”
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Nonlytic Lymphocytes Engineered to Express Virus-Specific T-Cell Receptors Limit HBV Infection by Activating APOBEC3 by Koh, Sarene, Kah, Janine, Tham, Christine Y.L., Yang, Ninghan, Ceccarello, Erica, Chia, Adeline, Chen, Margaret, Khakpoor, Atefeh, Pavesi, Andrea, Tan, Anthony T., Dandri, Maura, Bertoletti, Antonio

“…Strategies to develop virus-specific T cells against hepatic viral infections have been hindered by safety concerns. We engineered nonlytic human T cells to…”
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Pre-existing T cell-mediated cross-reactivity to SARS-CoV-2 cannot solely be explained by prior exposure to endemic human coronaviruses by Tan, Cedric C.S., Owen, Christopher J., Tham, Christine Y.L., Bertoletti, Antonio, van Dorp, Lucy, Balloux, Francois

“…T-cell-mediated immunity to SARS-CoV-2-derived peptides in individuals unexposed to SARS-CoV-2 has been previously reported. This pre-existing immunity was…”
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Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset by Kalimuddin, Shirin, Tham, Christine Y L, Qui, Martin, de Alwis, Ruklanthi, Sim, Jean X Y, Lim, Joey M E, Tan, Hwee-Cheng, Syenina, Ayesa, Zhang, Summer L, Le Bert, Nina, Tan, Anthony T, Leong, Yan Shan, Yee, Jia Xin, Ong, Eugenia Z, Ooi, Eng Eong, Bertoletti, Antonio, Low, Jenny G

“…RNA vaccines against coronavirus disease 2019 (COVID-19) have demonstrated ∼95% efficacy in phase III clinical trials. Although complete vaccination consisted…”
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PS-079-HDV co-infection modifies the immunoproteasome profile of HBV infected hepatocytes leading to increased CD8 T-cell recognition: Implication for immunotherapy by Tham, Christine Y.L., Kah, Janine, Tan, Anthony, Loglio, Alessandro, Sureau, Camille, Lütgehetmann, Marc, Lampertico, Pietro, Dandri, Maura, Bertoletti, Antonio

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T‐cell immunity against Severe Acute Respiratory Syndrome Coronavirus 2 proteins in patients with type 1 diabetes by Palmieri, Camillo, Santamaria, Gianluca, Cristiani, Costanza Maria, Garofalo, Cinzia, Tham, Christine Y. L., Abatino, Antonio, Cutruzzolà, Antonio, Parise, Martina, Aversa, Ilenia, Malanga, Donatella, Gallo, Raffaella, Cuda, Giovanni, Viglietto, Giuseppe, Costanzo, Francesco, Bertoletti, Antonio, Gnasso, Agostino, Irace, Concetta

“…Aims Individuals with type 1 diabetes (T1D) do not appear to have an elevated risk of severe Coronavirus Disease 19 (COVID‐19). Pre‐existing immune reactivity…”
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Adverse effects following anti-COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes by Syenina, Ayesa, Gan, Esther S, Toh, Justin Z N, de Alwis, Ruklanthi, Lin, Lowell Z, Tham, Christine Y L, Yee, Jia Xin, Leong, Yan Shan, Sam, Huizhen, Cheong, Charlene, Teh, Yii Ean, Wee, Ian L E, Ng, Dorothy H L, Chan, Kuan Rong, Sim, Jean X Y, Kalimuddin, Shirin, Ong, Eugenia Z, Low, Jenny G, Ooi, Eng Eong

“…Ensuring high vaccination and even booster vaccination coverage is critical in preventing severe Coronavirus Disease 2019 (COVID-19). Among the various…”
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Safety and efficacy of up to 76 weeks 10 mg (high dose) bulevirtide monotherapy in compensated cirrhotics with delta hepatitis by Loglio, Alessandro, Ferenci, Peter, Schlund, Franziska, Tham, Christine Y.L., van Bommel, Florian, Uceda Renteria, Sara Colonia, Borghi, Marta, Holzmann, Heidemarie, Perbellini, Riccardo, Trombetta, Elena, Giovanelli, Silvia, Porretti, Laura, Prati, Daniele, Ceriotti, Ferruccio, Lunghi, Giovanna, Bertoletti, Antonio, Urban, Stephan, Lampertico, Pietro

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SAT417 - Safety and efficacy of up to 76 weeks 10 mg (high dose) bulevirtide monotherapy in compensated cirrhotics with delta hepatitis by Loglio, Alessandro, Ferenci, Peter, Schlund, Franziska, Tham, Christine Y.L., van Bommel, Florian, Uceda Renteria, Sara Colonia, Borghi, Marta, Holzmann, Heidemarie, Perbellini, Riccardo, Trombetta, Elena, Giovanelli, Silvia, Porretti, Laura, Prati, Daniele, Ceriotti, Ferruccio, Lunghi, Giovanna, Bertoletti, Antonio, Urban, Stephan, Lampertico, Pietro

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Electron transport chain capacity expands yellow fever vaccine immunogenicity by Mok, Darren ZL, Tng, Danny JH, Yee, Jia Xin, Chew, Valerie SY, Tham, Christine YL, Ooi, Justin SG, Tan, Hwee Cheng, Zhang, Summer L, Lin, Lowell Z, Ng, Wy Ching, Jeeva, Lavanya Lakshmi, Murugayee, Ramya, Goh, Kelvin K-K, Lim, Tze-Peng, Cui, Liang, Cheung, Yin Bun, Ong, Eugenia Z, Chan, Kuan Rong, Ooi, Eng Eong, Low, Jenny G

“…Vaccination has successfully controlled several infectious diseases although better vaccines remain desirable. Host response to vaccination studies have…”
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