Effects of the neonicotinoid insecticide, clothianidin, on the reproductive organ system in adult male rats

Abstract Clothianidin (CTD) is a novel, broad-spectrum insecticide. In the current study, it was aimed to study the effect of subchronic exposure to low doses of CTD (2, 8 and 24 mg/kg body weight/day) on the reproductive system in adult rats. CTD treatment did not significantly change serum testost...

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Bibliographic Details
Published in:	Drug and chemical toxicology (New York, N.Y. 1978) Vol. 36; no. 4; pp. 421 - 429
Main Authors:	Bal, Ramazan, Türk, Gaffari, Tuzcu, Mehmet, Y lmaz, Ökkes, Kulo lu, Tuncay, Bayda, G yasettin, Naziro lu, Mustafa, Yener, Zabit, Etem, Ebru, Tuzcu, Zeynep
Format:	Journal Article
Language:	English
Published:	United States Informa Healthcare USA, Inc 01-10-2013 Taylor & Francis
Subjects:	alpha-Tocopherol - metabolism Analysis of Variance Animals Apoptosis Cholesterol - metabolism clothianidin DNA fragmentation DNA Fragmentation - drug effects Dose-Response Relationship, Drug Epididymis - drug effects fatty acid composition Genitalia, Male - drug effects Glutathione - metabolism Guanidines - toxicity Insecticides - toxicity lipid peroxidation Male Neonicotinoids Rats Seminal Vesicles - drug effects sperm characteristics Spermatozoa - drug effects Testosterone - blood Thiazoles - toxicity Thiobarbituric Acid Reactive Substances - metabolism Toxicity Tests
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Summary:	Abstract Clothianidin (CTD) is a novel, broad-spectrum insecticide. In the current study, it was aimed to study the effect of subchronic exposure to low doses of CTD (2, 8 and 24 mg/kg body weight/day) on the reproductive system in adult rats. CTD treatment did not significantly change serum testosterone level or sperm parameters (e.g. concentration, motility and morphology), but caused significant decreases in weights of epididymis, right cauda epididymis and seminal vesicles. CTD treatment did not cause sperm DNA fragmentation and did not change the apoptotic index in the seminiferous tubules and levels of α-tocopherol and glutathione, but increased the level of thiobarbituric acid-reactive substances and cholesterol levels significantly at all doses. CTD exposure caused significant elevations in palmitic, linoleic and arachidonic acids in testis in all CTD-exposed groups. There was a drop in 20:4/18:2 (arachidonic acid/linoleic acid) ratio and an increase in 18:1n-9/18:0 (oleic acid/stearic acid) ratios in all CTD groups, in comparison to the control group. In conclusion, CTD had little detectable detrimental effects on the reproductive system of male rats over the measured parameters.
ISSN:	0148-0545 1525-6014
DOI:	10.3109/01480545.2013.776575