Transferrin Saturation, Serum Ferritin, and C-Reactive Protein vs. Serum Ferritin for an optimal Iron Deficiency Diagnosis in Candidates for Bariatric Surgery

Introduction Iron has different physiological processes and is regulated by hepcidin that is also an acute phase reactant, which increases with inflammation. Obesity produces a pro-inflammatory state, affecting directly the normal regulation of iron, causing ferritin (FER) deficiency. FER is used as...

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Bibliographic Details
Published in:	Obesity surgery Vol. 34; no. 4; pp. 1174 - 1184
Main Authors:	Muñoz, M. Patricia Sánchez, Ramirez, Zuleyma P. Bello, Rodriguez, Eduardo L. Martínez, Blandón, José D. Reyes, Aguiñaga, Soledad Aldana, Orozco, César A. Ortiz, Yáñez, Allison R. Esparza
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-04-2024 Springer Nature B.V
Subjects:	Diagnostic tests Gastrointestinal surgery Iron Medicine Medicine & Public Health Obesity Original Contributions Surgery Iron deficiency C-reactive protein Ferritin
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Summary:	Introduction Iron has different physiological processes and is regulated by hepcidin that is also an acute phase reactant, which increases with inflammation. Obesity produces a pro-inflammatory state, affecting directly the normal regulation of iron, causing ferritin (FER) deficiency. FER is used as the only indicator of the status of iron in patients with obesity, so the majority of them would be underdiagnosed, leading to a high prevalence of iron deficiency (ID) and anemia. The aim of this study is to evaluate the diagnostic tests: transferrin saturation (TS), FER, and C-reactive protein (CRP) vs. FER with the objective of analyzing the most accurate variable for the diagnosis of ID. Materials and Methods We present a cross-sectional, analytical, and retrospective study, evaluating the diagnostic tests in 96 patients, to whom two methods were applied for the diagnosis of ID: method 1 (FER < 30 ng/mL) and method 2 divided into 2A (FER < 30 ng/mL), 2B (FER 30–100 ng/mL + CRP ≥ 5 mg/L), 2C (FER 100–300 ng/mL + CRP ≥ 5 mg/L + TS < 20%), and 2D (TS < 20%). Results The prevalence of ID obtained using method 1 was 30.2% while 69.8% presented ID using total method 2, confirming an underdiagnosis of 39.6%. Conclusion The inflammatory state in patients with obesity must be considered in the diagnosis of ID. The use of TS, FER, and CRP has greater validity than the use of serum FER for the diagnosis of ID in patients with obesity. Graphical Abstract
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-8923 1708-0428
DOI:	10.1007/s11695-024-07081-z