Urinary biomarkers of early renal injury in antiretroviral‐naïve HIV‐positive persons in Shanghai, China: comparison with the general population

Objectives People living with HIV (PLWH) have a high risk of kidney injury. Measurement of serum creatinine, along with proteinuria, is not sensitive to detect early kidney injury. Here, we investigated novel urinary biomarkers of early renal injury in PLWH. Methods We performed a cross‐sectional st...

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Bibliographic Details
Published in:	HIV medicine Vol. 22; no. 8; pp. 750 - 758
Main Authors:	Le, XQ, Liu, DP, Chen, J, Gong, ZY, Xun, JN, Wang, JR, Sun, JJ, Steinhart, C, Liu, L, Shen, YZ, Qi, TK, Wang, ZY, Zhang, X, Tang, Y, Song, W, Lu, HZ, Zhang, RF
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-09-2021 John Wiley and Sons Inc
Subjects:	Albumins Antiretroviral agents Biomarkers CD4 antigen China - epidemiology Cholesterol Creatinine Cross-Sectional Studies Epidermal growth factor Gelatinase Glomerular filtration rate Glucosaminidase Growth factors Health risks HIV HIV infection HIV Infections - complications HIV Infections - drug therapy HIV Infections - urine Human immunodeficiency virus Humans Injuries Kidney kidney injury Kidneys Leukocytes (neutrophilic) Lipocalin Lipocalin-2 Original Research propensity score matching Proteinuria Risk analysis Risk factors urinary biomarkers China urinary biomarkers propensity score matching kidney injury HIV infection
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Summary:	Objectives People living with HIV (PLWH) have a high risk of kidney injury. Measurement of serum creatinine, along with proteinuria, is not sensitive to detect early kidney injury. Here, we investigated novel urinary biomarkers of early renal injury in PLWH. Methods We performed a cross‐sectional study of 166 antiretroviral‐naïve PLWH and 99 HIV‐negative persons who all had an estimated glomerular filtration rate > 90 mL/min/1.73 m2. We compared the levels of seven urinary biomarkers between the two groups using the propensity score matching (PSM) approach and explored the risk factors associated with elevated urinary biomarkers in PLWH. Results Eighty‐three pairs were successfully matched based on PSM. Compared with the HIV‐negative group, the HIV‐positive group had higher ratios of N‐acetyl‐β‐D‐glucosaminidase (NAG) to urine creatinine (UCr), alpha1‐microglobulin (α1‐M) to UCr, kidney injury marker‐1 (KIM‐1) to UCr, neutrophil gelatinase‐associated lipocalin to UCr, and epidermal growth factor to UCr, whereas the Tamm–Horsfall protein to UCr ratio and the abnormal albumin to UCr ratio were not significantly different. Positive correlations were observed between HIV RNA level and NAG: UCr (rs = 0.32; P < 0.001) and α1‐M:UCr (rs = 0.24; P = 0.002) ratios, and negative correlations were observed between CD4 cell count and NAG:UCr (rs = –0.34; P < 0.001), KIM‐1:UCr (rs = –0.16; P = 0.042) and α1‐M:UCr (rs = –0.36; P < 0.001) ratios. In multivariate linear regression analyses, older age, lower total cholesterol and higher HIV RNA were independently associated with higher NAG:UCr; older age, lower total cholesterol and lower CD4 cell count were independently associated with higher α1‐M:UCr. Conclusions In comparioson with HIV‐negative participants, PLWH were more likely to have tubular injury. Early antiretroviral treatment might mitigate the development of kidney injury.
Bibliography:	These authors contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1464-2662 1468-1293
DOI:	10.1111/hiv.13123