Search Results - "Xu, Zhijiao"

Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing by Gu, Xi, Wang, Daqi, Xu, Zhijiao, Wang, Jinghan, Guo, Luo, Chai, Renjie, Li, Genglin, Shu, Yilai, Li, Huawei

“…Aging, noise, infection, and ototoxic drugs are the major causes of human acquired sensorineural hearing loss, but treatment options are limited. CRISPR/Cas9…”
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Rescue of autosomal dominant hearing loss by in vivo delivery of mini dCas13X-derived RNA base editor by Xiao, Qingquan, Xu, Zhijiao, Xue, Yuanyuan, Xu, Chunlong, Han, Lei, Liu, Yuanhua, Wang, Fang, Zhang, Runze, Han, Shuang, Wang, Xing, Li, Geng-Lin, Li, Huawei, Yang, Hui, Shu, Yilai

“…Programmable RNA editing tools enable the reversible correction of mutant transcripts, reducing the potential risk associated with permanent genetic changes…”
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Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system by Qiu, Wenqing, Xu, Zhijiao, Zhang, Min, Zhang, Dandan, Fan, Hui, Li, Taotao, Wang, Qianfeng, Liu, Peiru, Zhu, Zaihua, Du, Duo, Tan, Minjia, Wen, Bo, Liu, Yun

“…Abstract The architecture and function of chromatin are largely regulated by local interacting molecules, such as transcription factors and noncoding RNAs…”
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Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing by Zheng, Ziwen, Li, Guo, Cui, Chong, Wang, Fang, Wang, Xiaohan, Xu, Zhijiao, Guo, Huiping, Chen, Yuxin, Tang, Honghai, Wang, Daqi, Huang, Mingqian, Chen, Zheng-Yi, Huang, Xingxu, Li, Huawei, Li, Geng-Lin, Hu, Xiaoxiang, Shu, Yilai

“…CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave single-strand RNAs, which is a promising treatment for various disorders by…”
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Rescue of mis-splicing of a common SLC26A4 mutant associated with sensorineural hearing loss by antisense oligonucleotides by Feng, Pengchao, Xu, Zhijiao, Chen, Jialin, Liu, Meizhen, Zhao, Yu, Wang, Daqi, Han, Lei, Wang, Li, Wan, Bo, Xu, Xingshun, Li, Dali, Shu, Yilai, Hua, Yimin

“…A wide spectrum of SLC26A4 mutations causes Pendred syndrome and enlarged vestibular aqueduct, both associated with sensorineural hearing loss (SNHL). A…”
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Distributional comparison of different AAV vectors after unilateral cochlear administration by Han, Shuang, Xu, Zhijiao, Wang, Shengyi, Tang, Honghai, Hu, Shaowei, Wang, Hui, Guan, Guofang, Shu, Yilai

“…The adeno-associated virus (AAV) gene therapy has been widely applied to mouse models for deafness. But, AAVs could transduce non-targeted organs after inner…”
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Treatment of autosomal recessive hearing loss via in vivo CRISPR/Cas9-mediated optimized homology-directed repair in mice by Gu, Xi, Hu, Xinde, Wang, Daqi, Xu, Zhijiao, Wang, Fang, Li, Di, Li, Geng-lin, Yang, Hui, Li, Huawei, Zuo, Erwei, Shu, Yilai

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Gene editing in a Myo6 semi-dominant mouse model rescues auditory function by Xue, Yuanyuan, Hu, Xinde, Wang, Daqi, Li, Di, Li, Yige, Wang, Fang, Huang, Mingqian, Gu, Xi, Xu, Zhijiao, Zhou, Jinan, Wang, Jinghan, Chai, Renjie, Shen, Jun, Chen, Zheng-Yi, Li, Geng-Lin, Yang, Hui, Li, Huawei, Zuo, Erwei, Shu, Yilai

“…Myosin VI（MYO6） is an unconventional myosin that is vital for auditory and vestibular function. Pathogenic variants in the human MYO6 gene cause…”
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