Search Results - "Xu, Zhanwang"

Network Pharmacology-Based Pharmacological Mechanism of the Chinese Medicine Rhizoma drynariae Against Osteoporosis by Gan, Donghao, Xu, Xiaowei, Chen, Deqiang, Feng, Peng, Xu, Zhanwang

“…d_abstr_R Rhizoma drynariae is the main traditional Chinese medicine used for the treatment of osteoporosis, but its anti-osteoporotic targeting mechanism has…”
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Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration by Li, Zhichao, Wu, Yan, Tan, Guoqing, Xu, Zhanwang, Xue, Haipeng

“…Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor…”
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Cell life-or-death events in osteoporosis: All roads lead to mitochondrial dynamics by Li, Zhichao, Liang, Songlin, Ke, Liqing, Wang, Mengjie, Gao, Kuanhui, Li, Dandan, Xu, Zhanwang, Li, Nianhu, Zhang, Peng, Cheng, Wenxiang

“…Mitochondria exhibit heterogeneous shapes and networks within and among cell types and tissues, also in normal or osteoporotic bone tissues with complex cell…”
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Proteomic Analysis Based on TMT Regarding the Therapeutic Action of Rhizoma Drynariae on Rats in an Osteoporosis Model by Su, Hui, Yan, Binghan, Wang, Ruochong, Li, Zhichao, Xu, Zhanwang, Xue, Haipeng, Tan, Guoqing

“…Primary osteoporosis has increasingly become one of the risk factors affecting human health, and the clinical effect and action mechanism of traditional…”
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Regulatory mechanisms of autophagy-related ncRNAs in bone metabolic diseases by Yan, Binghan, Li, Zhichao, Su, Hui, Xue, Haipeng, Qiu, Daodi, Xu, Zhanwang, Tan, Guoqing

“…Bone metabolic diseases have been tormented and are plaguing people worldwide due to the lack of effective and thorough medical interventions and the poor…”
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Autophagy: An important target for natural products in the treatment of bone metabolic diseases by Li, Zhichao, Li, Dandan, Su, Hui, Xue, Haipeng, Tan, Guoqing, Xu, Zhanwang

“…Bone homeostasis depends on a precise dynamic balance between bone resorption and bone formation, involving a series of complex and highly regulated steps. Any…”
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Naringin promotes osteoblast differentiation and effectively reverses ovariectomy-associated osteoporosis by Xu, Zhanwang, Li, Nianhu, Wooley, Paul H., Yang, Shang-You, Jiang, Yunpeng

“…Osteoporosis is a common pathological condition that influences 20% of women over 50years of age. This condition decreases bone strength and increases the risk…”
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Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis by Gan, Donghao, Cheng, Wenxiang, Ke, Liqing, Sun, Antonia RuJia, Jia, Qingyun, Chen, Jianhai, Lin, Jietao, Li, Jian, Xu, Zhanwang, Zhang, Peng

“…Clinical studies have shown that pirfenidone (PFD) effectively relieves joint pain in rheumatoid arthritis (RA) patients. However, the detailed mechanisms…”
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Magnetic resonance imaging classification in a percutaneous needle injury rat model of intervertebral disc degeneration by Liang, Songlin, Li, Nianhu, Zhan, Jiawen, Li, Zhichao, Tie, Changjun, Zhu, Yanjie, Guo, Hongyan, Ke, Liqing, Li, Jian, Xu, Zhanwang, Zhang, Peng, Cheng, Wenxiang

“…During the development of disease-modifying intervertebral disc degeneration (IDD) drugs, the rat model of IDD is frequently used for disease progression…”
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Biphasic Effect of Pirfenidone on Angiogenesis by Gan, Donghao, Cheng, Wenxiang, Ke, Liqing, Sun, Antonia RuJia, Jia, Qingyun, Chen, Jianhai, Xu, Zhanwang, Xu, Juan, Zhang, Peng

“…Pirfenidone (PFD), a synthetic arsenic compound, has been found to inhibit angiogenesis at high concentrations. However, the biphasic effects of different PFD…”
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Effect of Rhizoma Drynariae on differential gene expression in ovariectomized rats with osteoporosis based on transcriptome sequencing by Su, Hui, Xue, Haipeng, Gao, Shang, Yan, Binghan, Wang, Ruochong, Tan, Guoqing, Xu, Zhanwang, Zeng, Lingfeng

“…Osteoporosis is increasingly becoming a serious problem affecting the quality of life of the older population. Several experimental studies have shown that…”
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The effect and mechanism of QufengZhitong capsule for the treatment of osteoarthritis in a rat model by Cheng, Wenxiang, Gan, Donghao, Hu, Yiping, Zheng, Zhengtan, Zeng, Qingqiang, Li, Ling, Wang, Xinluan, Zhang, Yong, Xu, Zhanwang, Qin, Ling, Zhang, Peng

“…The purpose of this study was to evaluate the therapeutic effects and mechanism of Qufeng Zhitong (QFZT)capsule for the treatment of osteoarthritis (OA) in a…”
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Effect of Bushenhuoxue formula on interleukin-1 beta and discoidin domain receptor 2 levels in a rat model of osteoarthritis by Nianhu, Li, Lei, Xia, Sheng, Yi, Jianhui, Yu, Yi, Zhai, Zhanwang, Xu

“…To determine the effects of Bushenhuoxue formula (BHF) on interleukin-1 beta (IL-1β), transforming growth factor beta 1 (TGF-β1), discoidin domain receptor 2…”
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Effects of estradiol on reduction of osteoarthritis in rabbits through effect on matrix metalloproteinase proteins by Wang, Weiguo, Wang, Lin, Xu, Zhanwang, Yin, Yanxia, Su, Jun, Niu, Xiufeng, Cao, Xuecheng

“…Osteoarthritis (OA), as a known degenerative joint disease, is the most common form of arthritis. In this study, we aimed to elucidate unclear pathogenesis of…”
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Individually integrated traditional Chinese medicine approach in the management of knee osteoarthritis: study protocol for a randomized controlled trial by Cao, Yuelong, Zhan, Hongsheng, Pang, Jian, Li, Feiyue, Xu, Shaojian, Gao, Jinghua, Xu, Zhanwang, Li, Gang, Liu, Ting, Guo, Chaoqing, Shi, Yinyu

“…Knee osteoarthritis (OA) is considered a major public health issue causing chronic disability worldwide with the increasing number of aging people. In China…”
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Cell death regulation: A new way for natural products to treat osteoporosis by Li, Zhichao, Li, Dandan, Chen, Renchang, Gao, Shang, Xu, Zhanwang, Li, Nianhu

“…Osteoporosis is a common metabolic bone disease that results from the imbalance of homeostasis within the bone. Intra-bone homeostasis is dependent on a…”
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Exploring the Mechanism of Acupuncture's Influence on the Protease Activity and Free Radical Damage in Synovial Fluid of Rheumatoid Arthritis Rats Induced by Type II Collagen from the Release of Active Oxygen by Cui, Kaiying, Bi, Dezhong, Wang, Fuyan, Hou, Pengfei, Guo, Jinxing, Xu, Zhanwang

“…Acupuncture was studied to investigate the mechanism of its effect on protease vitality and free radical damage in Type I CIA rats induced by type II collagen…”
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Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis by Gao, Kuanhui, Lv, Longlong, Li, Zhichao, Wang, Chenmoji, Zhang, Jiahao, Qiu, Daodi, Xue, Haipeng, Xu, Zhanwang, Tan, Guoqing

“…ABSTRACT Degenerative bone and joint diseases (DBJDs), characterized by osteoporosis, osteoarthritis, and chronic inflammation of surrounding soft tissues, are…”
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Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways by Jia, Qingyun, Cheng, Wenxiang, Yue, Ye, Hu, Yipping, Zhang, Jian, Pan, Xiaohua, Xu, Zhanwang, Zhang, Peng

“…Increasing studies indicated that Cucurbitacin E (CuE), a compound isolated from Cucurbitaceae, has been shown anti-inflammatory effect. However, the effect of…”
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Therapeutic effects of naringin on degenerative human nucleus pulposus cells for discogenic low back pain by Li, Nianhu, Whitaker, Camden, Xu, Zhanwang, Heggeness, Michael, Yang, Shang-You

“…Abstract Background Over half the population of the world will suffer moderate or severe low back pain (LBP) during their life span. Studies have shown that…”
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