Magnetic resonance imaging in screening women at high risk of breast cancer: A meta-analysis

Magnetic resonance imaging (MRI) is more accurate than mammography in screening for breast cancer. Exposure to ionizing radiation from repeated diagnostic X-rays may be a cause of breast cancer. We conducted systematic searches on PubMed, Cochrane and Embase to identify studies on women who underwen...

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Bibliographic Details
Published in:	Medicine (Baltimore) Vol. 102; no. 10; p. e33146
Main Authors:	Ding, Wu, Fan, Zaiwei, Xu, Yuehuai, Wei, Chunshou, Li, Zhian, Lin, Yingli, Zhu, Jianming, Ruan, Guodong
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins 10-03-2023
Subjects:	Breast Neoplasms - pathology Early Detection of Cancer - methods Female Humans Magnetic Resonance Imaging - methods Mammography - methods Risk Factors Systematic Review and Meta-Analysis
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Summary:	Magnetic resonance imaging (MRI) is more accurate than mammography in screening for breast cancer. Exposure to ionizing radiation from repeated diagnostic X-rays may be a cause of breast cancer. We conducted systematic searches on PubMed, Cochrane and Embase to identify studies on women who underwent mammography or MRI screening. A meta-analysis was performed to compare the detection rate of breast cancer by mammography, MRI or both. A total of 18 diagnostic publications were identified and included in the meta-analysis. Among the 1000 screened women, MRI alone increased the detection rate of breast cancer by 8 compared with mammography alone (RR 0.48, 95% CI 0.42-0.54), and MRI plus mammography increased the detection rate of breast cancer by 1 compared with MRI alone (RR 0.86, 95% CI 0.78-0.96). Subgroup analysis demonstrated that the diagnostic efficacy of MRI plus mammography in breast was obviously better than that of MRI alone or mammography alone. Screening with MRI alone might be the best choice for women at high risk of breast cancer.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0025-7974 1536-5964 1536-5964
DOI:	10.1097/MD.0000000000033146