Search Results - "Xu, Yingrong"

Delineating the role of cooperativity in the design of potent PROTACs for BTK by Zorba, Adelajda, Nguyen, Chuong, Xu, Yingrong, Starr, Jeremy, Borzilleri, Kris, Smith, James, Zhu, Hongyao, Farley, Kathleen A., Ding, WeiDong, Schiemer, James, Feng, Xidong, Chang, Jeanne S., Uccello, Daniel P., Young, Jennifer A., Garcia-Irrizary, Carmen N., Czabaniuk, Lara, Schuff, Brandon, Oliver, Robert, Montgomery, Justin, Hayward, Matthew M., Coe, Jotham, Chen, Jinshan, Niosi, Mark, Luthra, Suman, Shah, Jaymin C., El-Kattan, Ayman, Qiu, Xiayang, West, Graham M., Noe, Mark C., Shanmugasundaram, Veerabahu, Gilbert, Adam M., Brown, Matthew F., Calabrese, Matthew F.

“…Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that simultaneously bind to a target protein and an E3 ligase, thereby leading…”
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes by Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

“…Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein…”
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes by Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

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Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins? by Ogburn, Ryenne N., BS, Randall, Thomas A., PhD, Xu, Yingrong, BS, Roberts, Julia H., BS, Mebrahtu, Betelihem, Karnuta, Jaret M, Rider, S. Dean, PhD, Kissling, Grace E., PhD, London, Robert E., PhD, Pomés, Anna, PhD, Arlian, Larry, PhD, Fitzgerald, Michael C., PhD, Mueller, Geoffrey A., PhD

“…[...]many are outliers in the quartile analysis of the DP transcriptome. Other influences on sensitization include additional environmental exposures,…”
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Type I interferon regulation by USP18 is a key vulnerability in cancer by Jové, Veronica, Wheeler, Heather, Lee, Chiachin Wilson, Healy, David R., Levine, Kymberly, Ralph, Erik C., Yamaguchi, Masaya, Jiang, Ziyue Karen, Cabral, Edward, Xu, Yingrong, Stock, Jeffrey, Yang, Bing, Giddabasappa, Anand, Loria, Paula, Casimiro-Garcia, Agustin, Kessler, Benedikt M., Pinto-Fernández, Adán, Frattini, Véronique, Wes, Paul D., Wang, Feng

“…Precise regulation of Type I interferon signaling is crucial for combating infection and cancer while avoiding autoimmunity. Type I interferon signaling is…”
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Micro-mixing enhancement in a Taylor-Couette reactor using the inner rotors with various surface configurations by Li, Bin, Li, Guang, Yang, Xiaogang, Long, Shanshan, Xu, Yingrong, Liu, Lu, Zong, Yuan

“…•Effects of different surface designs of inner cylinders of TC reactor on micromixing were assessed.•Correlations for description of the enhancement of…”
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Thiomethyltetrazines Are Reversible Covalent Cysteine Warheads Whose Dynamic Behavior can be “Switched Off” via Bioorthogonal Chemistry Inside Live Cells by Tallon, Amanda M., Xu, Yingrong, West, Graham M., am Ende, Christopher W., Fox, Joseph M.

“…Electrophilic small molecules that can reversibly modify proteins are of growing interest in drug discovery. However, the ability to study reversible covalent…”
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Amphiphilic mesogen-jacketed liquid crystalline polymers: Design, synthesis, and self-assembly behaviors by Wu, Hongliang, Zhang, Lanying, Xu, Yingrong, Ma, Ziyue, Shen, Zhihao, Fan, Xinghe, Zhou, Qifeng

“…We synthesized a series of amphiphilic mesogen‐jacketed liquid crystalline (LC) polymers with a biphenyl side‐chain mesogen containing a carboxylic acid group…”
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A Comparison of Two Stability Proteomics Methods for Drug Target Identification in OnePot 2D Format by Xu, Yingrong, West, Graham M, Abdelmessih, Mario, Troutman, Matthew D, Everley, Robert A

“…Stability proteomics techniques that do not require drug modifications have emerged as an attractive alternative to affinity purification methods in drug…”
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Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1 by Orris, Benjamin, Sung, Min Woo, Bhat, Shridhar, Xu, Yingrong, Huynh, Kevin W, Han, Seungil, Johnson, Darren C, Bosbach, Benedikt, Shields, David J, Stivers, James T

“…Abstract The dNTPase activity of tetrameric SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) plays a critical role in…”
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Thermodynamic Analysis of Protein Folding and Stability Using a Tryptophan Modification Protocol by Xu, Yingrong, Strickland, Erin C, Fitzgerald, Michael C

“…Described here is the development of a mass spectrometry-based covalent labeling protocol that utilizes the reaction of…”
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Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange by Byrnes, Laura J., Xu, Yingrong, Qiu, Xiayang, Hall, Justin D., West, Graham M.

“…Cystic Fibrosis (CF) is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Mutations associated with CF cause…”
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Thermodynamic Analysis of the Geldanamycin–Hsp90 Interaction in a Whole Cell Lysate Using a Mass Spectrometry-Based Proteomics Approach by Xu, Yingrong, Wallace, M. Ariel Geer, Fitzgerald, Michael C.

“…Geldanamycin is a natural product with well-established and potent anti-cancer activities. Heat shock protein 90 (Hsp90) is the known target of geldanamycin,…”
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Development and Application of Covalent-Labeling Strategies for the Large-Scale Thermodynamic Analysis of Protein Folding and Ligand Binding by Xu, Yingrong

“…Thermodynamic stability measurements on proteins and protein-ligand complexes can offer insights not only into the fundamental properties of protein folding…”
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