Search Results - "Xu, Yechun"

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5 by Zhang, Hui, Chen, Kun, Tan, Qiuxiang, Shao, Qiang, Han, Shuo, Zhang, Chenhui, Yi, Cuiying, Chu, Xiaojing, Zhu, Ya, Xu, Yechun, Zhao, Qiang, Wu, Beili

“…The chemokine receptor CCR5 plays a vital role in immune surveillance and inflammation. However, molecular details that govern its endogenous chemokine…”
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Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease by Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Zhang, Yumin, Liu, Jia, Shao, Qiang, Wang, Qingxing, Li, Minjun, Xie, Hang, Shang, Weijuan, Ke, Changqiang, Feng, Lu, Jiang, Xiangrui, Shen, Jingshan, Xiao, Gengfu, Jiang, Hualiang, Zhang, Leike, Ye, Yang, Xu, Yechun

“…The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently needs an effective…”
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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir by Yin, Wanchao, Mao, Chunyou, Luan, Xiaodong, Shen, Dan-Dan, Shen, Qingya, Su, Haixia, Wang, Xiaoxi, Zhou, Fulai, Zhao, Wenfeng, Gao, Minqi, Chang, Shenghai, Xie, Yuan-Chao, Tian, Guanghui, Jiang, He-Wei, Tao, Sheng-Ce, Shen, Jingshan, Jiang, Yi, Jiang, Hualiang, Xu, Yechun, Zhang, Shuyang, Zhang, Yan, Xu, H Eric

“…The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis…”
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease by Dai, Wenhao, Zhang, Bing, Jiang, Xia-Ming, Su, Haixia, Li, Jian, Zhao, Yao, Xie, Xiong, Jin, Zhenming, Peng, Jingjing, Liu, Fengjiang, Li, Chunpu, Li, You, Bai, Fang, Wang, Haofeng, Cheng, Xi, Cen, Xiaobo, Hu, Shulei, Yang, Xiuna, Wang, Jiang, Liu, Xiang, Xiao, Gengfu, Jiang, Hualiang, Rao, Zihe, Zhang, Lei-Ke, Xu, Yechun, Yang, Haitao, Liu, Hong

“…SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the etiological agent responsible for the global COVID-19 (coronavirus disease 2019) outbreak…”
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Application of ITC-Based Characterization of Thermodynamic and Kinetic Association of Ligands With Proteins in Drug Design by Su, Haixia, Xu, Yechun

“…A comprehensive characterization of the thermodynamic and kinetic profiling of ligands binding to a given target protein is crucial for the hit selection as…”
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Structural basis of ligand binding modes at the human formyl peptide receptor 2 by Chen, Tong, Xiong, Muya, Zong, Xin, Ge, Yunjun, Zhang, Hui, Wang, Mu, Won Han, Gye, Yi, Cuiying, Ma, Limin, Ye, Richard D., Xu, Yechun, Zhao, Qiang, Wu, Beili

“…The human formyl peptide receptor 2 (FPR2) plays a crucial role in host defense and inflammation, and has been considered as a drug target for chronic…”
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Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase by Xu, Yechun, Jiang, Hualiang

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The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G‑Protein-Coupled Receptor by Yuan, Xiaojing, Raniolo, Stefano, Limongelli, Vittorio, Xu, Yechun

“…The crystal structure of P2Y1 receptor (P2Y1R), a class A GPCR, revealed a special extra-helical site for its antagonist, BPTU, which locates in-between the…”
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Recent Trends and Applications of Molecular Modeling in GPCR⁻Ligand Recognition and Structure-Based Drug Design by Yuan, Xiaojing, Xu, Yechun

“…G protein-coupled receptors represent the largest family of human membrane proteins and are modulated by a variety of drugs and endogenous ligands. Molecular…”
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Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2 by Xie, Yuanchao, Yin, Wanchao, Zhang, Yumin, Shang, Weijuan, Wang, Zhen, Luan, Xiaodong, Tian, Guanghui, Aisa, Haji A., Xu, Yechun, Xiao, Gengfu, Li, Jia, Jiang, Hualiang, Zhang, Shuyang, Zhang, Leike, Xu, H. Eric, Shen, Jingshan

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A New Differentially-Fed Frequency Reconfigurable Antenna for WLAN and Sub-6GHz 5G Applications by Jin, Guiping, Deng, Chuhong, Yang, Ju, Xu, Yechun, Liao, Shaowei

“…A new differentially fed frequency reconfigurable antenna adopting proximity-coupling feeding for WLAN and sub-6-GHz 5G applications is proposed in this paper…”
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Globba Hongman, a Cut-flower Cultivar with Red Bract Color and Long Vase Life by Ye, Yuanjun, Zhou, Yiwei, Tan, Jianjun, Huang, Lishan, Xu, Yechun

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Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV‑2 by Dai, Wenhao, Jochmans, Dirk, Xie, Hang, Yang, Hang, Li, Jian, Su, Haixia, Chang, Di, Wang, Jiang, Peng, Jingjing, Zhu, Lili, Nian, Yong, Hilgenfeld, Rolf, Jiang, Hualiang, Chen, Kaixian, Zhang, Leike, Xu, Yechun, Neyts, Johan, Liu, Hong

“…A novel series of peptidomimetic aldehydes was designed and synthesized to target 3C protease (3Cpro) of enterovirus 71 (EV71). Most of the compounds exhibited…”
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Gorge Motions of Acetylcholinesterase Revealed by Microsecond Molecular Dynamics Simulations by Cheng, Shanmei, Song, Wanling, Yuan, Xiaojing, Xu, Yechun

“…Acetylcholinesterase, with a deep, narrow active-site gorge, attracts enormous interest due to its particularly high catalytic efficiency and its inhibitors…”
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Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir by Jiang, Xiangrui, Su, Haixia, Shang, Weijuan, Zhou, Feng, Zhang, Yan, Zhao, Wenfeng, Zhang, Qiumeng, Xie, Hang, Jiang, Lei, Nie, Tianqing, Yang, Feipu, Xiong, Muya, Huang, Xiaoxing, Li, Minjun, Chen, Ping, Peng, Shaoping, Xiao, Gengfu, Jiang, Hualiang, Tang, Renhong, Zhang, Leike, Shen, Jingshan, Xu, Yechun

“…The persistent pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants…”
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Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells by Wu, Dang, Wang, Wanyan, Chen, Wuyan, Lian, Fulin, Lang, Li, Huang, Ying, Xu, Yechun, Zhang, Naixia, Chen, Yinbin, Liu, Mingyao, Nussinov, Ruth, Cheng, Feixiong, Lu, Weiqiang, Huang, Jin

“…Acute myeloid leukemia is a disorder characterized by abnormal differentiation of myeloid cells and a clonal proliferation derived from primitive hematopoietic…”
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Characterization of EST-SSR markers in Curcuma kwangsiensis S. K. Lee & C. F. Liang based on RNA sequencing and its application for phylogenetic relationship analysis and core collection construction by Ye, Yuanjun, Xu, Yechun, Li, Dongmei, Tan, Jianjun, Liu, Jinmei

“…Curcuma kwangsiensis S. K. Lee & C. F. Liang, a traditional herb in southern China, accumulates substantial amounts of active components, curcuminoids and…”
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Computational Studies on Acetylcholinesterases by Xu, Yechun, Cheng, Shanmei, Sussman, Joel L, Silman, Israel, Jiang, Hualiang

“…Functions of biomolecules, in particular enzymes, are usually modulated by structural fluctuations. This is especially the case in a gated diffusion-controlled…”
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Bispecific prodrug nanoparticles circumventing multiple immune resistance mechanisms for promoting cancer immunotherapy by Ye, Jiayi, Hou, Bo, Chen, Fangmin, Zhang, Shunan, Xiong, Muya, Li, Tianliang, Xu, Yechun, Xu, Zhiai, Yu, Haijun

“…Cancer immunotherapy is impaired by the intrinsic and adaptive immune resistance. Herein, a bispecific prodrug nanoparticle was engineered for circumventing…”
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Pigment Diversity in Leaves of Caladium × hortulanum Birdsey and Transcriptomic and Metabolic Comparisons between Red and White Leaves by Zhou, Yiwei, Xu, Yechun, Zhu, Gen-Fa, Tan, Jianjun, Lin, Jingyi, Huang, Lishan, Ye, Yuanjun, Liu, Jinmei

“…Leaf color is a key ornamental characteristic of cultivated caladium ( × Birdsey), a plant with diverse leaf colors. However, the genetic improvement of leaf…”
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