Search Results - "Xu, Ya‐Fei"

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43 by Stoica, Radu, De Vos, Kurt J., Paillusson, Sébastien, Mueller, Sarah, Sancho, Rosa M., Lau, Kwok-Fai, Vizcay-Barrena, Gema, Lin, Wen-Lang, Xu, Ya-Fei, Lewis, Jada, Dickson, Dennis W., Petrucelli, Leonard, Mitchell, Jacqueline C., Shaw, Christopher E., Miller, Christopher C. J.

“…Mitochondria and the endoplasmic reticulum (ER) form tight structural associations and these facilitate a number of cellular functions. However, the mechanisms…”
Get full text

FNDC3B 3′‐UTR shortening escapes from microRNA‐mediated gene repression and promotes nasopharyngeal carcinoma progression by Li, Ying‐Qing, Chen, Yang, Xu, Ya‐Fei, He, Qing‐Mei, Yang, Xiao‐Jing, Li, Ying‐Qin, Hong, Xiao‐Hong, Huang, Sheng‐Yan, Tang, Ling‐Long, Liu, Na

“…Alternative polyadenylation (APA), which induces shortening of the 3′‐UTR, is emerging as an important feature in cancer development and progression…”
Get full text

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress by Zhang, Yong-Jie, Jansen-West, Karen, Xu, Ya-Fei, Gendron, Tania F., Bieniek, Kevin F., Lin, Wen-Lang, Sasaguri, Hiroki, Caulfield, Thomas, Hubbard, Jaime, Daughrity, Lillian, Chew, Jeannie, Belzil, Veronique V., Prudencio, Mercedes, Stankowski, Jeannette N., Castanedes-Casey, Monica, Whitelaw, Ena, Ash, Peter E. A., DeTure, Michael, Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

“…The occurrence of repeat-associated non-ATG (RAN) translation, an atypical form of translation of expanded repeats that results in the synthesis of…”
Get full text

Structural determinants of the cellular localization and shuttling of TDP-43 by Ayala, Youhna M, Zago, Paola, D'Ambrogio, Andrea, Xu, Ya-Fei, Petrucelli, Leonard, Buratti, Emanuele, Baralle, Francisco E

“…TDP-43 (also known as TARDBP) regulates different processes of gene expression, including transcription and splicing, through RNA and DNA binding. Moreover,…”
Get full text

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation by Zhang, Yong-Jie, Caulfield, Thomas, Xu, Ya-Fei, Gendron, Tania F, Hubbard, Jaime, Stetler, Caroline, Sasaguri, Hiroki, Whitelaw, Ena C, Cai, Shuyi, Lee, Wing Cheung, Petrucelli, Leonard

“…TAR DNA-binding protein-43 (TDP-43) is the principal component of ubiquitinated inclusions in amyotrophic lateral sclerosis (ALS) and the most common…”
Get full text

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice by Xu, Ya-Fei, Gendron, Tania F, Zhang, Yong-Jie, Lin, Wen-Lang, D'Alton, Simon, Sheng, Hong, Casey, Monica Castanedes, Tong, Jimei, Knight, Joshua, Yu, Xin, Rademakers, Rosa, Boylan, Kevin, Hutton, Mike, McGowan, Eileen, Dickson, Dennis W, Lewis, Jada, Petrucelli, Leonard

“…Transactivation response DNA-binding protein 43 (TDP-43) is a principal component of ubiquitinated inclusions in frontotemporal lobar degeneration with…”
Get full text

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity by Zhang, Yong-Jie, Xu, Ya-Fei, Cook, Casey, Gendron, Tania F, Roettges, Paul, Link, Christopher D, Lin, Wen-Lang, Tong, Jimei, Castanedes-Casey, Monica, Ash, Peter, Gass, Jennifer, Rangachari, Vijayaraghavan, Buratti, Emanuele, Baralle, Francisco, Golde, Todd E, Dickson, Dennis W, Petrucelli, Leonard

“…Inclusions of TAR DNA-binding protein-43 (TDP-43), a nuclear protein that regulates transcription and RNA splicing, are the defining histopathological feature…”
Get full text

ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor by Liu-Yesucevitz, Liqun, Lin, Amy Y, Ebata, Atsushi, Boon, Joon Y, Reid, Whitney, Xu, Ya-Fei, Kobrin, Kendra, Murphy, George J, Petrucelli, Leonard, Wolozin, Benjamin

“…Trans-activating response region (TAR) DNA-binding protein of 43 kDa (TDP-43) is an RNA-binding protein that is mutated in familial amyotrophic lateral…”
Get full text

Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-43 by Zhang, Yong-Jie, Xu, Ya-fei, Dickey, Chad A, Buratti, Emanuele, Baralle, Francisco, Bailey, Rachel, Pickering-Brown, Stuart, Dickson, Dennis, Petrucelli, Leonard

“…TAR DNA binding protein-43 (TDP-43) is the pathologic substrate of neuronal and glial inclusions in frontotemporal lobar degeneration with ubiquitin-positive…”
Get full text

Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for Progranulin in Successful Aging by Ahmed, Zeshan, Sheng, Hong, Xu, Ya-fei, Lin, Wen-Lang, Innes, Amy E, Gass, Jennifer, Yu, Xin, Hou, Harold, Chiba, Shuichi, Yamanouchi, Keitaro, Leissring, Malcolm, Petrucelli, Leonard, Nishihara, Masugi, Hutton, Michael L, McGowan, Eileen, Dickson, Dennis W, Lewis, Jada

“…Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in…”
Get full text

MicroRNA-93 promotes cell growth and invasion in nasopharyngeal carcinoma by targeting disabled homolog-2 by Xu, Ya-Fei, Mao, Yan-Ping, Li, Ying-Qin, Ren, Xian-Yue, He, Qing-Mei, Tang, Xin-Ran, Sun, Ying, Liu, Na, Ma, Jun

“…Highlights • MiR-93 is upregulated in nasopharyngeal carcinoma cell lines and clinical tissues. • Inhibition of miR-93 suppresses NPC cell growth, invasion and…”
Get full text

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice by Xu, Ya-Fei, Zhang, Yong-Jie, Lin, Wen-Lang, Cao, Xiangkun, Stetler, Caroline, Dickson, Dennis W, Lewis, Jada, Petrucelli, Leonard

“…Abnormal distribution, modification and aggregation of transactivation response DNA-binding protein 43 (TDP-43) are the hallmarks of multiple neurodegenerative…”
Get full text

The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo by Sasaguri, Hiroki, Chew, Jeannie, Xu, Ya-Fei, Gendron, Tania F, Garrett, Aliesha, Lee, Chris W, Jansen-West, Karen, Bauer, Peter O, Perkerson, Emilie A, Tong, Jimei, Stetler, Caroline, Zhang, Yong-Jie

“…Abstract Inclusions of Tar DNA- binding protein 43 (TDP-43) are a pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar…”
Get full text

The Effect of Work Engagement and Perceived Organizational Support on Turnover Intention among Nurses: A Meta-Analysis Based on the Price–Mueller Model by Zhu, Li-Li, Wang, Hui-Juan, Xu, Ya-Fei, Ma, Shu-Ting, Luo, Yan-Yan

“…Aim. To elaborate on the relationship between work engagement, perceived organizational support, and the turnover intention of nurses by analysing some…”
Get full text

Genome-Wide Identification of a Methylation Gene Panel as a Prognostic Biomarker in Nasopharyngeal Carcinoma by Jiang, Wei, Liu, Na, Chen, Xiao-Zhong, Sun, Ying, Li, Bin, Ren, Xian-Yue, Qin, Wei-Feng, Jiang, Ning, Xu, Ya-Fei, Li, Ying-Qin, Ren, Jian, Cho, William C S, Yun, Jing-Ping, Zeng, Jing, Liu, Li-Zhi, Li, Li, Guo, Ying, Mai, Hai-Qiang, Zeng, Mu-Sheng, Kang, Tie-Bang, Jia, Wei-Hua, Shao, Jian-Yong, Ma, Jun

“…DNA methylation, the best known epigenetic marker, can be used as a prognostic biomarker in many cancers. We examined DNA methylation status and survival in…”
Get full text

The Proinflammatory Cytokines IL-18, IL-21, and IFN-γ Differentially Regulate Liver Inflammation and Anti-Mitochondrial Antibody Level in a Murine Model of Primary Biliary Cholangitis by Xu, Ya-Fei, Yao, Yuan, Ma, Min, Yang, Shu-Han, Jiang, Peng, Wang, Jinjun, Tsuneyama, Koichi, Wang, Chan, Liu, Xiangdong, Li, Liang, Lian, Zhe-Xiong

“…Primary biliary cholangitis (PBC) is a cholestatic liver disease primarily featured by autoimmune-mediated damage of intrahepatic small- and medium-sized bile…”
Get full text

Association Between Environmental Factors and Oral Epstein-Barr Virus DNA Loads: A Multicenter Cross-sectional Study in China by He, Yong-Qiao, Liao, Xiao-Yu, Xue, Wen-Qiong, Xu, Ya-Fei, Xu, Feng-Hua, Li, Fang-Fang, Li, Xi-Zhao, Zhang, Jiang-Bo, Wang, Tong-Min, Wang, Fang, Yu, Huan-Lin, Feng, Qi-Sheng, Chen, Li-Zhen, Cao, Su-Mei, Liu, Qing, Mu, Jianbing, Jia, Wei-Hua

“…Abstract Background Oral Epstein-Barr virus (EBV) status reflects host EBV activity and potentially links to EBV-associated diseases, however, factors…”
Get full text

Characterization of Organ-Specific Regulatory B Cells Using Single-Cell RNA Sequencing by Yang, Si-Yu, Long, Jie, Huang, Meng-Xing, Luo, Pan-Yue, Bian, Zhen-Hua, Xu, Ya-Fei, Wang, Cheng-Bo, Yang, Shu-Han, Li, Liang, Selmi, Carlo, Gershwin, M Eric, Zhao, Zhi-Bin, Lian, Zhe-Xiong

“…Regulatory B cells (Breg) are considered as immunosuppressive cells. Different subsets of Breg cells have been identified both in human beings and in mice…”
Get full text

Comparison of the Effectiveness of New Material Diapers versus Standard Diapers for the Prevention of Diaper Rash in Chinese Babies: A Double-Blinded, Randomized, Controlled, Cross-Over Study by Ishida, Koichi, Xu, Ya-fei, Yao, Xue-Qiu, Takagi, Rinko, Yuan, Chao, Toyoshima, Haruko

“…Background. Diaper rash, also known as diaper dermatitis (DD), is a very common skin condition in infants, and use of disposable diapers with breathable…”
Get full text

Akt and CHIP Coregulate Tau Degradation through Coordinated Interactions by Dickey, Chad A., Koren, John, Zhang, Yong-Jie, Xu, Ya-fei, Jinwal, Umesh K., Birnbaum, Morris J., Monks, Bobby, Sun, Mei, Cheng, Jin Q., Patterson, Cam, Bailey, Rachel M., Dunmore, Judith, Soresh, Sareh, Leon, Carlos, Morgan, Dave, Petrucelli, Leonard

“…A hallmark of the pathology of Alzheimer's disease is the accumulation of the microtubule-associated protein tau into fibrillar aggregates. Recent studies…”
Get full text