Comparison of bactericidal activity after multidose administration of clarithromycin, azithromycin, and cefuroxime axetil against Streptococcus pneumoniae

Comparison of bactericidal activity after multidose administration of clarithromycin, azithromycin, and cefuroxime axetil against Streptococcus pneumoniae

The objective of this study was to compare the duration of serum bactericidal activity (SBA) for clarithromycin, azithromycin, and cefuroxime axetil in 12 young healthy volunteers after 5 days of therapy (dosed to steady-state) against two strains each of penicillin (PCN)-susceptible, -intermediate,...

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Bibliographic Details
Published in:International journal of antimicrobial agents Vol. 10; no. 4; pp. 279 - 283
Main Authors: Lacy, Melinda K., Owens, Robert C., Xu, Xiqwei, Nicolau, David P., Quintiliani, Richard, Nightingale, Charles H.
Format: Journal Article
Language:English
Published: London Elsevier B.V 01-11-1998
Amsterdam Elsevier
New York, NY
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Azithromycin
Bactericidal
Biological and medical sciences
Cefuroxime axetil
Clarithromycin
Medical sciences
Pharmacology. Drug treatments
Pneumococcus
Streptococcus pneumoniae
Clarithromycin
Cefuroxime axetil
Pneumococcus
Bactericidal
Azithromycin
Streptococcus pneumoniae
Human
Healthy subject
β-Lactams
In vitro
Macrolide
Bactericidal effect
Streptococcaceae
Cefuroxime
Antibiotic
Cephalosporin derivatives
Sensitivity resistance
Bacteria
Micrococcales
Serum
Antibacterial agent
Pharmacokinetics
Comparative study
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Summary:The objective of this study was to compare the duration of serum bactericidal activity (SBA) for clarithromycin, azithromycin, and cefuroxime axetil in 12 young healthy volunteers after 5 days of therapy (dosed to steady-state) against two strains each of penicillin (PCN)-susceptible, -intermediate, and -resistant Streptococcus pneumoniae. This was a randomized, 3-way crossover study. All isolates were susceptible to clarithromycin (MICs 0.125 mg/l) and azithromycin (MICs 0.25–0.5 mg/l), while cefuroxime axetil susceptibilities correlated with PCN. Results showed that SBA was maintained for 100% of the dosing interval for clarithromycin and 50–100% for azithromycin regardless of PCN susceptibility when standard doses were employed. Cefuroxime axetil was active only against the PCN-susceptible isolate for 50% of the dosing interval, indicating that it should only be used for PCN-susceptible S. pneumoniae.
Bibliography:ObjectType-Article-2
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ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(98)00057-0