Search Results - "Xu, Xiao‐En"

Integrated molecular profiling of young and elderly patients with triple‐negative breast cancer indicates different biological bases and clinical management strategies by Ma, Ding, Jiang, Yi‐Zhou, Xiao, Yi, Xie, Meng‐Dan, Zhao, Shen, Jin, Xi, Xu, Xiao‐En, Shao, Zhi‐Ming

“…Background Age at the time of breast cancer diagnosis not only predicts clinical outcome but also indicates distinct molecular characteristics that provide the…”
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LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer by Jin, Xi, Ge, Li-Ping, Li, Da-Qiang, Shao, Zhi-Ming, Di, Gen-Hong, Xu, Xiao-En, Jiang, Yi-Zhou

“…Estrogen receptor-positive (ER+) breast cancers represent approximately two-thirds of all breast cancers and have a sustained risk of late disease recurrence…”
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Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype-specific RNAs of triple-negative breast cancer by Liu, Yi-Rong, Jiang, Yi-Zhou, Xu, Xiao-En, Yu, Ke-Da, Jin, Xi, Hu, Xin, Zuo, Wen-Jia, Hao, Shuang, Wu, Jiong, Liu, Guang-Yu, Di, Gen-Hong, Li, Da-Qiang, He, Xiang-Huo, Hu, Wei-Guo, Shao, Zhi-Ming

“…Triple-negative breast cancer (TNBC) is a highly heterogeneous group of cancers, and molecular subtyping is necessary to better identify molecular-based…”
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Dual Characteristics of Novel HER2 Kinase Domain Mutations in Response to HER2-Targeted Therapies in Human Breast Cancer by Zuo, Wen-Jia, Jiang, Yi-Zhou, Wang, Yu-Jie, Xu, Xiao-En, Hu, Xin, Liu, Guang-Yu, Wu, Jiong, Di, Gen-Hong, Yu, Ke-Da, Shao, Zhi-Ming

“…Somatic mutations in the tyrosine kinase domain of human epidermal growth factor receptor 2 (HER2) may be an alternative mechanism to HER2 activation and can…”
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Molecular Features and Functional Implications of Germline Variants in Triple-Negative Breast Cancer by Ma, Ding, Chen, Si-Yu, Ren, Jin-Xiao, Pei, Yu-Chen, Jiang, Cong-Wei, Zhao, Shen, Xiao, Yi, Xu, Xiao-En, Liu, Guang-Yu, Hu, Xin, Liang, Xiao-Zhen, Yu, Ke-Da, Li, Da-Qiang, Jiang, Yi-Zhou, Shao, Zhi-Ming

“…The germline variant spectrum of triple-negative breast cancer (TNBC) is different from that of other subtypes and has demonstrated ethnic differences…”
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The early-stage triple-negative breast cancer landscape derives a novel prognostic signature and therapeutic target by Yang, Yun-Song, Ren, Yi-Xing, Liu, Cheng-Lin, Hao, Shuang, Xu, Xiao-En, Jin, Xi, Jiang, Yi-Zhou, Shao, Zhi-Ming

“…Purpose Triple-negative breast cancer (TNBC) is a highly heterogeneous disease. Patients with early-stage TNBCs have distinct likelihood of distant recurrence…”
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MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer by Wu, Si-Yu, Xiao, Yi, Wei, Jin-Li, Xu, Xiao-En, Jin, Xi, Hu, Xin, Li, Da-Qiang, Jiang, Yi-Zhou, Shao, Zhi-Ming

“…BackgroundTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and lacks definite treatment targets. Tumor immune…”
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The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation by Jin, Xi, Xu, Xiao-En, Jiang, Yi-Zhou, Liu, Yi-Rong, Sun, Wei, Guo, Ya-Jie, Ren, Yi-Xing, Zuo, Wen-Jia, Hu, Xin, Huang, Sheng-Lin, Shen, Hong-Jie, Lan, Fei, He, Yun-Fei, Hu, Guo-Hong, Di, Gen-Hong, He, Xiang-Huo, Li, Da-Qiang, Liu, Suling, Yu, Ke-Da, Shao, Zhi-Ming

“…Human endogenous retroviruses (HERVs) play pivotal roles in the development of breast cancer. However, the detailed mechanisms of noncoding HERVs remain…”
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GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer by Wei, Jin-Li, Wu, Si-Yu, Yang, Yun-Song, Xiao, Yi, Jin, Xi, Xu, Xiao-En, Hu, Xin, Li, Da-Qiang, Jiang, Yi-Zhou, Shao, Zhi-Ming

“…PurposeRegulatory T cells (Tregs) heavily infiltrate triple-negative breast cancer (TNBC), and their accumulation is affected by the metabolic reprogramming in…”
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SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer by Liu, Xi-Yu, Jiang, Wang, Ma, Ding, Ge, Li-Ping, Yang, Yun-Song, Gou, Zong-Chao, Xu, Xiao-En, Shao, Zhi-Ming, Jiang, Yi-Zhou

“…Background: Taxanes are frontline chemotherapeutic drugs for patients with triple-negative breast cancer (TNBC); however, chemoresistance reduces their…”
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Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation by Chen, Sun-Xia, Xu, Xiao-En, Wang, Xiao-Qing, Cui, Shu-Jian, Xu, Lei-Lei, Jiang, Ying-Hua, Zhang, Yang, Yan, Hai-Bo, Zhang, Qian, Qiao, Jie, Yang, Peng-Yuan, Liu, Feng

“…Stromal microenvironment influences tumor cell proliferation and migration. Fibroblasts represent the most abundant stromal constituents. Here, we established…”
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Serum GFAP autoantibody as an ELISA-detectable glioma marker by Wei, Ping, Zhang, Wei, Yang, Liu-Song, Zhang, Hai-Shi, Xu, Xiao-En, Jiang, Ying-Hua, Huang, Feng-Ping, Shi, Qian

“…Glioma is the most common primary brain tumor, yet the high cost of diagnostic imaging has made early detection of asymptomatic glioma a formidable challenge…”
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Transcriptome Analysis of Triple-Negative Breast Cancer Reveals an Integrated mRNA-lncRNA Signature with Predictive and Prognostic Value by Jiang, Yi-Zhou, Liu, Yi-Rong, Xu, Xiao-En, Jin, Xi, Hu, Xin, Yu, Ke-Da, Shao, Zhi-Ming

“…While recognized as a generally aggressive disease, triple-negative breast cancer (TNBC) is highly diverse in different patients with variable outcomes. In…”
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Inhibition of ACAA1 Restrains Proliferation and Potentiates the Response to CDK4/6 Inhibitors in Triple-Negative Breast Cancer by Peng, Wen-Ting, Jin, Xi, Xu, Xiao-En, Yang, Yun-Song, Ma, Ding, Shao, Zhi-Ming, Jiang, Yi-Zhou

“…Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with unfavorable outcomes. Developing therapeutic targets for TNBC remains a…”
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Comprehensive Transcriptome Profiling Reveals Multigene Signatures in Triple-Negative Breast Cancer by Liu, Yi-Rong, Jiang, Yi-Zhou, Xu, Xiao-En, Hu, Xin, Yu, Ke-Da, Shao, Zhi-Ming

“…By integrating expression profiles of mRNAs and long noncoding RNAs (lncRNA), we tried to develop and validate novel multigene signatures to facilitate…”
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Genomic Landscape and Endocrine-Resistant Subgroup in Estrogen Receptor-Positive, Progesterone Receptor-Negative, and HER2-Negative Breast Cancer by Liu, Xi-Yu, Ma, Ding, Xu, Xiao-En, Jin, Xi, Yu, Ke-Da, Jiang, Yi-Zhou, Shao, Zhi-Ming

“…Estrogen receptor-positive, progesterone receptor-negative, and human epidermal growth factor receptor 2 (HER2)-negative (ER+PR-HER2-) breast cancer comprise a…”
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Data from a proteomic analysis of colonic fibroblasts secretomes by Chen, Sun-Xia, Xu, Xiao-En, Wang, Xiao-Qing, Cui, Shu-Jian, Xu, Lei-Lei, Jiang, Ying-Hua, Zhang, Yang, Yan, Hai-Bo, Zhang, Qian, Qiao, Jie, Yang, Peng-Yuan, Liu, Feng

“…The tumor cell proliferation, migration and invasion were influenced by the interaction between the cancer cells and their microenvironment. In current study,…”
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Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer by Gao, Shui-Ping, Sun, He-Fen, Jiang, Hong-Lin, Li, Liang-Dong, Hu, Xin, Xu, Xiao-En, Jin, Wei

“…COX5B, a peripheral subunit of the cytochrome c oxidase complex, has previously been reported to maintain the stability of this complex. However, its functions…”
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DSCAM-AS1 regulates the G 1 /S cell cycle transition and is an independent prognostic factor of poor survival in luminal breast cancer patients treated with endocrine therapy by Sun, Wei, Li, An-Qi, Zhou, Ping, Jiang, Yi-Zhou, Jin, Xi, Liu, Yi-Rong, Guo, Ya-Jie, Yang, Wen-Tao, Shao, Zhi-Ming, Xu, Xiao-En

“…DSCAM-AS1 is one of the few intensively studied lncRNAs with high specific expression in luminal breast cancer. It is directly regulated by estrogen receptor α…”
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Loss of TIM50 suppresses proliferation and induces apoptosis in breast cancer by Gao, Shui-Ping, Sun, He-Fen, Jiang, Hong-Lin, Li, Liang-Dong, Hu, Xin, Xu, Xiao-En, Jin, Wei

“…TIM50 is an essential component of TIM23 complex and involved in protein translocating into the inner mitochondrial membrane. Here, we found that TIM50 was…”
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