Search Results - "Xu, WenLian"

A UDP-X diphosphatase from Streptococcus pneumoniae hydrolyzes precursors of peptidoglycan biosynthesis by Duong-Ly, Krisna C, Woo, Hyun Nyun, Dunn, Christopher A, Xu, WenLian, Babič, Andrej, Bessman, Maurice J, Amzel, L Mario, Gabelli, Sandra B

“…The gene for a Nudix enzyme (SP_1669) was found to code for a UDP-X diphosphatase. The SP_1669 gene is localized among genes encoding proteins that participate…”
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The Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic Activities by DUONG-LY, Krisna C, GABELLI, Sandra B, WENLIAN XU, DUNN, Christopher A, SCHOEFFIELD, Andrew J, BESSMAN, Maurice J, MARIO AMZEL, L

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Three New Nudix Hydrolases from Escherichia coli by Xu, Wenlian, Dunn, Christopher A., O'Handley, Suzanne F., Smith, Denise L., Bessman, Maurice J.

“…Three members of the Nudix (nucleoside diphosphate X) hydrolase superfamily have been cloned from Escherichia coli MG1655 and expressed. The proteins have been…”
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The 26 Nudix Hydrolases of Bacillus cereus, a Close Relative of Bacillus anthracis by Xu, WenLian, Dunn, Christopher A, Jones, Candice R, D'Souza, Gehaan, Bessman, Maurice J

“…The genome of Bacillus cereus contains 26 Nudix hydrolase genes, second only to its closest relative, Bacillus anthracis which has 30. All 26 genes have been…”
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Legionella pneumophila NudA Is a Nudix Hydrolase and Virulence Factor by Edelstein, Paul H, Hu, Baofeng, Shinzato, Takashi, Edelstein, Martha A. C, Xu, Wenlian, Bessman, Maurice J

“…We studied the identity and function of the 528-bp gene immediately upstream of Legionella pneumophila F2310 ptsP (enzyme I[superscript Ntr]). This gene, nudA,…”
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Gene ytkD of Bacillus subtilis Encodes an Atypical Nucleoside Triphosphatase Member of the Nudix Hydrolase Superfamily by Xu, Wenlian, Jones, Candice R, Dunn, Christopher A, Bessman, Maurice J

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The Nudix hydrolases of Deinococcus radiodurans by Xu, WenLian, Shen, JianYing, Dunn, Christopher A., Desai, Seema, Bessman, Maurice J.

“…All 21 of the Nudix hydrolase genes from the radiation‐resistant organism Deinococcus radiodurans have been cloned into vectors under the control of T7…”
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The Rickettsia prowazekii Invasion Gene Homolog (invA) Encodes a Nudix Hydrolase Active on Adenosine (5′)-pentaphospho-(5′)-adenosine by Gaywee, Jariyanart, Xu, WenLian, Radulovic, Suzana, Bessman, Maurice J, Azad, Abdu F

“…The genomic sequence of Rickettsia prowazekii , the obligate intracellular bacterium responsible for epidemic typhus, reveals an uncharacterized invasion gene…”
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A New Subfamily of the Nudix Hydrolase Superfamily Active on 5-Methyl-UTP (Ribo-TTP) and UTP by Xu, WenLian, Shen, JianYing, Dunn, Christopher A., Bessman, Maurice J.

“…A new subfamily of the Nudix hydrolases, identified by conserved amino acids upstream and downstream of the Nudix box, has been characterized. The cloned,…”
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The pnhA Gene of Pasteurella multocida Encodes a Dinucleoside Oligophosphate Pyrophosphatase Member of the Nudix Hydrolase Superfamily by Urick, Tonia, I-Chang, Chien, Arena, Ellen, Xu, WenLian, Bessman, Maurice J., Ruffolo, Carmel G.

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The Gene e.1 (nudE.1) of T4 Bacteriophage Designates a New Member of the Nudix Hydrolase Superfamily Active on Flavin Adenine Dinucleotide, Adenosine 5′-Triphospho-5′-adenosine, and ADP-ribose by Xu, WenLian, Gauss, Peter, Shen, JianYing, Dunn, Christopher A., Bessman, Maurice J.

“…The T4 bacteriophage gene e.1 was cloned into an expression vector and expressed in Escherichia coli, and the purified protein was identified as a Nudix…”
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Cloning and Characterization of the NADH Pyrophosphatases from Caenorhabditis elegans and Saccharomyces cerevisiae, Members of a Nudix Hydrolase Subfamily by Xu, WenLian, Dunn, Christopher A., Bessman, Maurice J.

“…Two genes from Caenorhabditis elegans and Saccharomyces cerevisiae, coding for enzymes homologous to the Nudix hydrolase family of nucleotide pyrophosphatases,…”
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Phase I study of KN035, the first subcutaneously administered, novel fusion anti-PD-L1 antibody in patients with advanced solid tumors in China by Xu, Jian-Ming, Qin, Shukui, Zhang, Yun, Zhang, Yaoyue, Jia, Ru, Liu, Rongrui, Zhang, Gairong, Zhao, Chuanhua, Lu, Ni, Liu, Huilong, Xu, Wenlian, Fu, Meng, Cao, Walt, Lu, Haolan, Liu, David, Dong, Ruiping, Wang, Xiaoxiao, Wang, Pilin, Xu, Ting, Gong, John

“…Abstract only 2608 Background: KN035 is a novel fusion protein of humanized anti-PD-L1 single domain antibody and human IgG1 Fc fragment, formulated for…”
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Phase I safety and pharmacokinetic study of KN035, the first subcutaneously administered, novel fusion anti-PD-L1 antibody in Japanese patients with advanced solid tumors by Shimizu, Toshio, Nakajima, Takako Eguchi, Lu, Ni, Xue, Shilin, Xu, Wenlian, Fu, Meng, Cao, Walt, Lu, Haolan, Liu, David, Dong, RuiPing, Wang, Xiaoxiao, Wang, Pilin, Zhu, Danming, Xu, Ting, Gong, John

“…Abstract only 2609 Background: KN035 is a novel fusion protein of humanized anti-PD-L1 single domain antibody and human IgG1 Fc, formulated for subcutaneous…”
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A phase I, open, multiple dose, dose escalation and expansion study to evaluate the safety, tolerability, and pharmacokinetics of KN035 (anti-PD-L1 antibody) administered in subcutaneous injection as a single agent to Chinese subjects with advanced solid tumors by Xu, Jianming, Qin, Shukui, Zhang, Yun, Zhang, Yaoyue, Jia, Ru, Liu, Rongrui, Wang, Yan, Zhang, Gairong, Zhao, Chuanhua, Lu, Ni, Ma, Xiaoyu, He, Yue, Yuan, Liwei, Lin, Yihui, Xu, Wenlian, Wang, Xiaoxiao, Wang, Pilin, Xu, Ting, Dong, RuiPing, Gong, John

“…Abstract only…”
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CDP-Chase, a CDP-Choline Pyrophosphatase, is a Member of a Novel Nudix Family in Gram-Positive Bacteria by Duong-Ly, Krisna C., Gabelli, Sandra B., Xu, WenLian, Dunn, Christopher A., Bessman, Maurice J., Amzel, L. Mario

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Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition by Boto, Agedi N., Xu, Wenlian, Jakoncic, Jean, Pannuri, Archana, Romeo, Tony, Bessman, Maurice J., Gabelli, Sandra B., Amzel, L. Mario

“…The Nudix hydrolase superfamily, characterized by the presence of the signature sequence GX5EX7REUXEEXGU (where U is I, L, or V), is a well‐studied family in…”
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Synthesis and photochemical properties of novel 4-diarylamine-1,8-naphthalimide derivatives by Jiang, Wei, Sun, Yueming, Wang, Xiaoliang, Wang, Qi, Xu, Wenlian

“…Several novel, diarylamine-substituted 1,8-naphthalimide derivatives were synthesized and characterized by FT-IR, 1H, 13C NMR, mass spectra and elemental…”
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Structure and Function of the E. coli Dihydroneopterin Triphosphate Pyrophosphatase: A Nudix Enzyme Involved in Folate Biosynthesis by Gabelli, Sandra B., Bianchet, Mario A., Xu, WenLian, Dunn, Christopher A., Niu, Zhi-Dian, Amzel, L. Mario, Bessman, Maurice J.

“…Nudix hydrolases are a superfamily of pyrophosphatases, most of which are involved in clearing the cell of potentially deleterious metabolites and in…”
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A UDP-X Diphosphatase from Streptococcus pneumoniae Hydrolyzes Precursors of Peptidoglycan Biosynthesis. e64241 by Duong-Ly, Krisna C, Woo, Hyun Nyun, Dunn, Christopher A, Xu, WenLian, Babic, Andrej, Bessman, Maurice J, Amzel, L Mario, Gabelli, Sandra B

“…The gene for a Nudix enzyme (SPUL1669) was found to code for a UDP-X diphosphatase. The SPUL1669 gene is localized among genes encoding proteins that…”
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