Search Results - "Xu, Weiren"

Discovery of Novel PI3Kδ Inhibitors Based on the p110δ Crystal Structure by Jia, Wenqing, Luo, Shuyu, Zhao, Wennan, Xu, Weiren, Zhong, Yuxu, Kong, Dexin

“…PI3Kδ is a key mediator of B-cell receptor signaling and plays an important role in the pathogenesis of certain hematological malignancies, such as chronic…”
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Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes by Studer, Elaine, Zhou, Xiqiao, Zhao, Renping, Wang, Yun, Takabe, Kazuaki, Nagahashi, Masayuki, Pandak, William M., Dent, Paul, Spiegel, Sarah, Shi, Ruihua, Xu, Weiren, Liu, Xuyuan, Bohdan, Pat, Zhang, Luyong, Zhou, Huiping, Hylemon, Phillip B.

“…Bile acids have been shown to be important regulatory molecules for cells in the liver and gastrointestinal tract. They can activate various cell signaling…”
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Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method by Sun, Zhiping, He, Lingli, Yang, Qingqing, Zhang, Haizhi, Xu, Weiren, Qin, Xinguang, Liu, Gang, Hu, Zhongze, Zhang, Luyong, Liu, Changxiao

“…The influence of genetic polymorphism of metabolic enzymes on drug–drug interactions (DDI) should be thoroughly investigated owing to its remarkable effect on…”
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Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor by Cai, Wenqing, Wu, Jingwei, Liu, Wei, Xie, Yafei, Liu, Yuqiang, Zhang, Shuo, Xu, Weiren, Tang, Lida, Wang, Jianwu, Zhao, Guilong

“…In order to systematically explore and better understand the structure-activity relationship (SAR) of a diarylmethane backbone in the design of potent uric…”
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Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives by Zhang, Datong, Wang, Guangtian, Zhao, Guilong, Xu, Weiren, Huo, Lingyan

“…A series of novel 3-(1H-indole-3-yl)-1H-pyrazole-5-carbohydrazide derivatives 4Ia-n, 4IIa-b and 6 were prepared by hydrazinolysis of ethyl…”
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Discovery of a Flexible Triazolylbutanoic Acid as a Highly Potent Uric Acid Transporter 1 (URAT1) Inhibitor by Tian, He, Liu, Wei, Zhou, Zhixing, Shang, Qian, Liu, Yuqiang, Xie, Yafei, Liu, Changying, Xu, Weiren, Tang, Lida, Wang, Jianwu, Zhao, Guilong

“…In order to systematically explore and understand the structure-activity relationship (SAR) of a lesinurad-based hit ( ) derived from the replacement of the S…”
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Novel Anthranilamide-Based FXa Inhibitors: Drug Design, Synthesis and Biological Evaluation by Wang, Wenzhi, Yuan, Jing, Fu, Xiaoli, Meng, Fancui, Zhang, Shijun, Xu, Weiren, Xu, Yongnan, Huang, Changjiang

“…Factor Xa (FXa) plays a significant role in the blood coagulation cascade and it has become a promising target for anticoagulation drugs. Three oral direct FXa…”
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GLP-1 analogs containing disulfide bond exhibited prolonged half-life in vivo than GLP-1 by Li, Ying, Zheng, Xuemin, Tang, Lida, Xu, Weiren, Gong, Min

“…► GLP-1 analog (GLP17057) containing an inter-disulfide bond extended its half-life. ► The analog (GLP17057) remained the biological activity of GLP-1. ►…”
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The influence of genetic polymorphisms in drug metabolism enzymes and transporters on the pharmacokinetics of different fluvastatin formulations by Xiang, Qian, Wu, Weidang, Zhao, Nan, Li, Chuan, Xu, Junyu, Ma, Lingyue, Zhang, Xiaodan, Xie, Qiufen, Zhang, Zhuo, Wang, Jiancheng, Xu, Weiren, Zhao, Xia, Cui, Yimin

“…The purpose of the present study was to investigate the impact of genetic polymorphism on fluvastatin pharmacokinetics. In addition, we compared the…”
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Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages by Zha, Weibin, Wang, Guangji, Xu, Weiren, Liu, Xuyuan, Wang, Yun, Zha, Beth S, Shi, Jian, Zhao, Qijin, Gerk, Phillip M, Studer, Elaine, Hylemon, Phillip B, Pandak, Jr, William M, Zhou, Huiping

“…HIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that…”
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Discovery of Flexible Naphthyltriazolylmethane-based Thioacetic Acids as Highly Active Uric Acid Transporter 1 (URAT1) Inhibitors for the Treatment of Hyperuricemia of Gout by Zhang, Xiansheng, Wu, Jingwei, Liu, Wei, Liu, Yuqiang, Xie, Yafei, Shang, Qian, Zhou, Zhixing, Xu, Weiren, Tang, Lida, Wang, Jianwu, Zhao, Guilong

“…Gout is the most common inflammatory arthritis, which, if left untreated or inadequately treated, will lead to joint destruction, bone erosion and disability…”
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Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles by Zhang, Datong, Wang, Zongheng, Xu, Weiren, Sun, Fanggang, Tang, Lida, Wang, Jianwu

“…A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of…”
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Design, Synthesis and Biological Activity of Tetrazole-bearing Uric Acid Transporter 1 Inhibitors by Cai, Wenqing, Liu, Wei, Xie, Yafei, Wu, Jingwei, Liu, Yuqiang, Liu, Changying, Xu, Weiren, Tang, Lida, Wang, Jianwu, Zhao, Guilong

“…Systematic structure-activity relationship（SAR） exploration of a moderately active tetrazole-bearmg lesinurad-based hit If led to the discovery of a potent…”
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Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings by Zhang, Datong, Jia, Jiong, Meng, Lijuan, Xu, Weiren, Tang, Lida, Wang, Jianwu

“…Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial…”
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Effects of Astragaloside IV on heart failure in rats by Zhao, Zhuanyou, Wang, Weiting, Wang, Fang, Zhao, Kerui, Han, Yingmei, Xu, Weiren, Tang, Lida

“…Astragaloside IV (ASI) in Radix Astragali is believed to be the active component in treating heart failure. The present study aims to examine the effects of…”
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Discovery of 6-deoxydapagliflozin as a highly potent sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes by Zhang, Lingyu, Wang, Yuli, Xu, Huaqiang, Shi, Yongheng, Liu, Bingni, Wei, Qunchao, Xu, Weiren, Tang, Lida, Wang, Jianwu, Zhao, Guilong

“…Systematic mono-deoxylation of the four hydroxyl groups in the glucose moiety in dapagliflozin led to the discovery of 6-deoxydapagliflozin 1 as a more active…”
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Disulfide bond prolongs the half-life of therapeutic peptide-GLP-1 by Li, Ying, Li, Xin, Zheng, Xuemin, Tang, Lida, Xu, Weiren, Gong, Min

“…► GLP-1 homodimeric analog (hdGLP1G10C) extended the biological half-life of GLP-1. ► hdGLP1G10C remained the biological activity of GLP-1. ► hdGLP1G10C showed…”
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A novel GLP-1 analog exhibits potent utility in the treatment of type 2 diabetes with an extended half-life and efficient glucose clearance in vivo by Li, Ying, Xu, Weiren, Tang, Lida, Gong, Min, Zhang, Jianning

“…► GLP-1 analog (GLP715a) containing an inter-disulfide bond and a Trp-cage extended its half-life. ► The analog (GLP715a) remained the biological activity of…”
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Synthesis and biological evaluation of 3-(1H-indol-3-yl)pyrazole-5-carboxylic acid derivatives by Zhang, Datong, Wang, Guangtian, Tan, Chubing, Xu, Weiren, Pei, Yuan, Huo, Lingyan

“…A series of novel compounds bearing a 3-(1 H -indol-3-yl)pyrazole-5-carboxylic acid nucleus were synthesized. Analytical and spectral data confirmed the…”
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1-(5-Bromo-2-chlorophenyl)-2,2-dichloro-1-(4-ethoxyphenyl)cyclopropane by Han, Shuwen, Shi, Yongheng, Yuli, Wang, Zhao, Guilong, Xu, Weiren

“…The asymmetric unit of the title compound, C17H14BrCl3O, contains two independent molecules with different dihedral angles between the benzene rings [79.2 (1)…”
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