Search Results - "Xu, Sulan"

Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel by Xu, Sulan, Huang, Chun-Han, Eyermann, Christopher, Georgakis, Georgios V., Turkman, Nashaat

“…The design and radiosynthesis of [ 18 F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step…”
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Development of a Radiolabeled Cyclin-Dependent Kinases 4 and 6 (CDK4/6) Inhibitor for Brain and Cancer PET Imaging by Huang, Chun-Han, Khan, Palwasha, Xu, Sulan, Cohen, Jules, Georgakis, Georgios V, Turkman, Nashaat

“…The synthesis, biochemical evaluation and radiosynthesis of a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor and radioligand was performed. NT431, a newly…”
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Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet by Luo, Yongde, Yang, Yaying, Liu, Muyun, Wang, Dan, Wang, Feng, Bi, Yawei, Ji, Juntao, Li, Suyun, Liu, Yan, Chen, Rong, Huang, Haojie, Wang, Xiaojie, Swidnicka-Siergiejko, Agnieszka K., Janowitz, Tobias, Beyaz, Semir, Wang, Guoqiang, Xu, Sulan, Bialkowska, Agnieszka B., Luo, Catherine K., Pin, Christoph L., Liang, Guang, Lu, Xiongbin, Wu, Maoxin, Shroyer, Kenneth R., Wolff, Robert A., Plunkett, William, Ji, Baoan, Li, Zhaoshen, Li, Ellen, Li, Xiaokun, Yang, Vincent W., Logsdon, Craig D., Abbruzzese, James L., Lu, Weiqin

“…Obesity is a risk factor for pancreatic cancer. In mice, a high-fat diet (HFD) and expression of oncogenic KRAS lead to development of invasive pancreatic…”
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p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo by Alexandrova, Evguenia M, Mirza, Safia A, Xu, Sulan, Schulz-Heddergott, Ramona, Marchenko, Natalia D, Moll, Ute M

“…Missense mutations in TP53 comprise >75% of all p53 alterations in cancer, resulting in highly stabilized mutant p53 proteins that not only lose their…”
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In Vitro Model of Platelet-Endothelial Activation Due to Cigarette Smoke Under Cardiovascular Circulation Conditions by Girdhar, Gaurav, Xu, Sulan, Jesty, Jolyon, Bluestein, Danny

“…Cigarette smoke has been shown to increase platelet activation and endothelial cell (EC) adhesion molecule expression. In the present study, we utilized a…”
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High-Contrast PET Imaging with [18F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System by Turkman, Nashaat, Xu, Sulan, Huang, Chun-Han, Eyermann, Christopher, Salino, Julia, Khan, Palwasha

“…We utilized positron emission tomography (PET) imaging in vivo to map the spatiotemporal biodistribution/expression of class-IIa histone deacetylases…”
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Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18 F-radiolabel by Xu, Sulan, Huang, Chun-Han, Eyermann, Christopher, Georgakis, Georgios V, Turkman, Nashaat

“…The design and radiosynthesis of [ F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step…”
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Ganetespib synergizes with cyclophosphamide to improve survival of mice with autochthonous tumors in a mutant p53-dependent manner by Alexandrova, Evguenia M, Xu, Sulan, Moll, Ute M

“…The DNA-alkylating cytotoxic agent cyclophosphamide (CTX) is commonly used in the clinic to treat hematological malignancies like lymphomas and leukemias as…”
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Structure-function analysis of gC1qR/p33 using deletion mutants show additional binding sites for C1q. (134.69) by Xu, Sulan, Menzies, Catherine A, Vinayagasundaram, Rama, Mathew, Sally, Vinayagasundaram, Uma, Peerschke, Ellinor I.B, Jesty, Jolyon

“…Abstract Surface expressed or soluble gC1qR has been shown to activate complement and to play a role in various inflammatory processes. By peptide mapping and…”
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Reduced-nicotine cigarettes increase platelet activation in smokers "in vivo": A dilemma in harm reduction by Girdhar, Gaurav, Xu, Sulan, Bluestein, Danny, Jesty, Jolyon

“…Nicotine is a primary constituent of tobacco and smoke, and its roles in causing addiction and causing disease are commonly conflated. In the present work, we…”
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Structure-function studies using deletion mutants identify domains of gC1qR/p33 as potential therapeutic targets for vascular permeability and inflammation by Ghebrehiwet, Berhane, Jesty, Jolyon, Xu, Sulan, Vinayagasundaram, Rama, Vinayagasundaram, Uma, Ji, Yan, Valentino, Alisa, Hosszu, Kinga K, Mathew, Sally, Joseph, Kusumam, Kaplan, Allen P, Peerschke, Ellinor I B

“…The endothelial cell receptor complex for kininogen (HK) comprises gC1qR, cytokeratin 1, and urokinase-type plasminogen activator receptor and is essential for…”
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