Search Results - "Xu, Stacey"

A robust scoring system to evaluate sepsis severity in an animal model by Shrum, Bradly, Anantha, Ram V, Xu, Stacey X, Donnelly, Marisa, Haeryfar, S M Mansour, McCormick, John K, Mele, Tina

“…The lack of a reliable scoring system that predicts the development of septic shock and death precludes comparison of disease and/or treatment outcomes in…”
Get full text

Gonococcal Pelvic Inflammatory Disease: Placing Mechanistic Insights Into the Context of Clinical and Epidemiological Observations by Xu, Stacey X, Gray-Owen, Scott D

“…Abstract While infection by Neisseria gonorrhoeae is often asymptomatic in women, undetected infections can ascend into the upper genital tract to elicit an…”
Get full text

Neisseria gonorrhoeae co-infection exacerbates vaginal HIV shedding without affecting systemic viral loads in human CD34+ engrafted mice by Xu, Stacey X, Leontyev, Danila, Kaul, Rupert, Gray-Owen, Scott D

“…HIV synergy with sexually transmitted co-infections is well-documented in the clinic. Co-infection with Neisseria gonorrhoeae in particular, increases genital…”
Get full text

Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci by Li, Jingru, Wang, Wenliang, Xu, Stacey X, Magarvey, Nathan A, McCormick, John K

“…The production of the staphylococcal exotoxin toxic shock syndrome toxin-1 (TSST-1) by Staphylococcus aureus has been associated with essentially all cases of…”
Get full text

Staphylococcal superantigens in colonization and disease by Xu, Stacey X, McCormick, John K

“…Superantigens (SAgs) are a family of potent immunostimulatory exotoxins known to be produced by only a few bacterial pathogens, including Staphylococcus…”
Get full text

Bacterial superantigens promote acute nasopharyngeal infection by Streptococcus pyogenes in a human MHC Class II-dependent manner by Kasper, Katherine J, Zeppa, Joseph J, Wakabayashi, Adrienne T, Xu, Stacey X, Mazzuca, Delfina M, Welch, Ian, Baroja, Miren L, Kotb, Malak, Cairns, Ewa, Cleary, P Patrick, Haeryfar, S M Mansour, McCormick, John K

“…Establishing the genetic determinants of niche adaptation by microbial pathogens to specific hosts is important for the management and control of infectious…”
Get full text

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production by Tuffs, Stephen W, Goncheva, Mariya I, Xu, Stacey X, Craig, Heather C, Kasper, Katherine J, Choi, Joshua, Flannagan, Ronald S, Kerfoot, Steven M, Heinrichs, David E, McCormick, John K

“…is a foremost bacterial pathogen responsible for a vast array of human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from that…”
Get full text

The SaeRS Two-Component System Is a Direct and Dominant Transcriptional Activator of Toxic Shock Syndrome Toxin 1 in Staphylococcus aureus by Baroja, Miren L, Herfst, Christine A, Kasper, Katherine J, Xu, Stacey X, Gillett, Daniel A, Li, Jingru, Reid, Gregor, McCormick, John K

“…Toxic shock syndrome toxin 1 (TSST-1) is a Staphylococcus aureus superantigen that has been implicated in both menstrual and nonmenstrual toxic shock syndrome…”
Get full text

Staphylococcus aureus keratinocyte invasion is mediated by integrin‐linked kinase and Rac1 by Sayedyahossein, Samar, Xu, Stacey X., Rudkouskaya, Alena, McGavin, Martin J., McCormick, John K., Dagnino, Lina

“…ABSTRACT Staphylococcus aureus is a major component of the skin microbiota and causes a large number of serious infections. S. aureus first interacts with…”
Get full text

T-cell engineered with a fully humanized B-cell maturation antigen-specific T-cell antigen coupler receptor effectively target multiple myeloma by Bezverbnaya, Ksenia, Hammill, Joanne A., Cummings, Derek, Bojovic, Bojana, Groisman, Bella, Baker, Christopher L., Aarts, Craig, Hayes, Danielle L., Rill, Donna, Xu, Stacey X., Bader, Andreas G., Helsen, Christopher W., Bramson, Jonathan L.

“…B-cell maturation antigen (BCMA) is a clinically validated target for multiple myeloma. T-cell engineered with chimeric antigen receptors (CARs) directed…”
Get full text

Invariant Natural Killer T Cells Are Pathogenic in the HLA-DR4—Transgenic Humanized Mouse Model of Toxic Shock Syndrome and Can Be Targeted to Reduce Morbidity by Szabo, Peter A., Rudak, Patrick T., Choi, Joshua, Xu, Stacey X., Schaub, Robert, Singh, Bhagirath, McCormick, John K., Haeryfar, S. M. Mansour

“…During toxic shock syndrome (TSS), bacterial superantigens trigger a polyclonal T -cell response leading to a potentially catastrophic "cytokine storm."…”
Get full text

Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo by Xu, Stacey X, Gilmore, Kevin J, Szabo, Peter A, Zeppa, Joseph J, Baroja, Miren L, Haeryfar, S M Mansour, McCormick, John K

“…Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating toxins known as superantigens (SAgs). Although excessive immune…”
Get full text

Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization by Xu, Stacey X, Kasper, Katherine J, Zeppa, Joseph J, McCormick, John K

“…Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T cells in a T cell receptor (TCR) Vβ-specific manner, resulting in…”
Get full text

118 Development of Claudin 18.2 TAC T cells for the treatment of gastric cancer by Helsen, Christopher, Benatar, Tania, Philbert, IP, Xu, Stacey, Shaver, Laura, Nitya-Nootan, Thanyashanthi, Bader, Andreas, Lal, Prabha

“…BackgroundThe T cell antigen coupler (TAC) is a novel, proprietary chimeric receptor that facilitates the re-direction of T cells to tumor cells and activates…”
Get full text

Nasopharyngeal Infection of Mice with Streptococcus pyogenes and In Vivo Detection of Superantigen Activity by Zeppa, Joseph J, Wakabayashi, Adrienne T, Kasper, Katherine J, Xu, Stacey X, Haeryfar, S M Mansour, McCormick, John K

“…Streptococcus pyogenes is a globally prominent human-specific pathogen that is responsible for an enormous burden of infectious disease. Despite intensive…”
Get more information

372 TAC-T cells persist and remain functional during and after repeated tumor exposure in vitro and in vivo by MacGregor, Heather L, Prosser, Suzanna L, Xu, Stacey X, MacDonald, Kyle, Kadri, Aksha, Randhawa, Ritu R, Shetty, Swati, Pirati, Sailaja, Bhemarasetty, Deepika, Helsen, Christopher W, Sengupta, Sadhak, Bader, Andreas G

“…BackgroundT cell antigen coupler (TAC) is a chimeric receptor that redirects T cells (TAC-T) towards surface-expressed tumor antigens to create safe and…”
Get full text

347 Functional characterization of GUCY2C-TAC T cells for the treatment of colorectal cancer using preclinical models by Benatar, Tania, Nitya-Nootan, Thanyashanthi, Thakor, Gargi, Prosser, Suzanna L, Ip, Philbert, Lal, Prabha, Khan, Alima, Xu, Stacey X, Pirati, Sailaja, Bhemarasetty, Deepika, Helsen, Christopher W, Bader, Andreas G

“…BackgroundThe T cell antigen coupler (TAC) is a novel chimeric receptor that facilitates the redirection of T cells to tumor cells and activates T cells by…”
Get full text

400 Preclinical characterization and modelling of allogeneic Vγ9Vδ2 TAC T cells for the treatment of solid tumors by Xu, Stacey X, Prosser, Suzanna L, Wang, Ling, Randhawa, Ritu R, Pirati, Sailaja, Bhemarasetty, Deepika, MacDonald, Kyle, Yoo, Seung Mi, Jung, Miyoung E, Gheorghiu, Laurentia A, Ayers, Chris L, Sengupta, Sadhak, Helsen, Christopher W, Bader, Andreas G

“…BackgroundThe T cell antigen coupler (TAC) is a novel, proprietary chimeric receptor that facilitates the redirection of T cells to tumor cells and activates T…”
Get full text

Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract by Islam, Epshita A, Anipindi, Varun C, Francis, Ian, Shaik-Dasthagirisaheb, Yazdan, Xu, Stacey, Leung, Nelly, Sintsova, Anna, Amin, Mohsen, Kaushic, Charu, Wetzler, Lee M, Gray-Owen, Scott D

“…The gonococcal Opa proteins are an antigenically variable family of surface adhesins that bind human carcinoembryonic antigen-related cell adhesion molecule 1…”
Get full text

Invariant NKT cells are pathogenic in the HLA-DR4-transgenic humanized mouse model of toxic shock syndrome and can be targeted to reduce morbidity by Szabo, Peter A., Rudak, Patrick T., Choi, Joshua, Xu, Stacey X., Schaub, Robert, Singh, Bhagirath, McCormick, John K., Haeryfar, S.M. Mansour

Get full text