Search Results - "Xu, Shizan"

LncRNA FIRRE functions as a tumor promoter by interaction with PTBP1 to stabilize BECN1 mRNA and facilitate autophagy by Wang, Yajie, Li, Zhengyang, Xu, Shizan, Li, Wenjun, Chen, Mengyun, Jiang, Miao, Fan, Xiaoming

“…Long non-coding RNAs (lncRNAs) play critical functions in various cancers. Firre intergenic repeating RNA element (FIRRE), a lncRNA located in the nucleus, was…”
Get full text

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways by Wu, Liwei, Zhang, Qinghui, Mo, Wenhui, Feng, Jiao, Li, Sainan, Li, Jingjing, Liu, Tong, Xu, Shizan, Wang, Wenwen, Lu, Xiya, Yu, Qiang, Chen, Kan, Xia, Yujing, Lu, Jie, Xu, Ling, Zhou, Yingqun, Fan, Xiaoming, Guo, Chuanyong

“…The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a characteristic response to acute or chronic liver injury. Mice were…”
Get full text

By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma by Li, Sainan, Dai, Weiqi, Mo, Wenhui, Li, Jingjing, Feng, Jiao, Wu, Liwei, Liu, Tong, Yu, Qiang, Xu, Shizan, Wang, Wenwen, Lu, Xiya, Zhang, Qinghui, Chen, Kan, Xia, Yujing, Lu, Jie, Zhou, Yingqun, Fan, Xiaoming, Xu, Ling, Guo, Chuanyong

“…Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the…”
Get full text

LncRNA GAS5 Knockdown Mitigates Hepatic Lipid Accumulation via Regulating MiR-26a-5p/PDE4B to Activate cAMP/CREB Pathway by Xu, Shizan, Wang, Yajie, Li, Zhengyang, Hua, Qian, Jiang, Miao, Fan, Xiaoming

“…ObjectiveNon-alcoholic fatty liver disease (NAFLD) can be attributed to the dysregulation of hepatic lipid metabolism; however, its cellular and molecular…”
Get full text

Hepatoprotective effect of quercetin via TRAF6/JNK pathway in acute hepatitis by Wu, Liwei, Wang, Chengfen, Li, Jingjing, Li, Sainan, Feng, Jiao, Liu, Tong, Xu, Shizan, Wang, Wenwen, Lu, Xiya, Chen, Kan, Xia, Yujing, Fan, Xiaoming, Guo, Chuanyong

“…Quercetin, as a member of the flavonoids family, has many beneficial properties. The aim of our study was to evaluate the protective effect of quercetin in…”
Get full text

Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway by Cheng, Keran, Zhou, Yuqing, Weiqi, Dai, Chen, Kan, Wang, Fan, Lu, Jie, Zhou, Ying-Qun, Guo, Chuan-Yong, Xu, Shizan, Zhang, Rong, Wu, Liwei, Feng, Jiao, Li, Sainan, Li, Jingjing, Xia, Yujing, Liu, Tong, Zhou, Shunfeng

“…Objective. Shikonin possesses anti-inflammatory effects. However, its function in concanavalin A-induced acute liver injury remains uncertain. The aim of the…”
Get full text

Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ by Li, Sainan, Liu, Tong, Lu, Xiya, Shi, Yanhong, Zhou, Ying-Qun, He, Weigang, Dai, Qi, Zheng, Yuejuan, Lu, Jie, Wu, Liwei, Feng, Jiao, Chen, Kan, Xu, Shizan, Li, Jingjing, Wang, Nan, Luo, Hui, Kong, Rui, Xia, Yujing

“…Portulaca oleracea L. is a traditional Chinese medicine, which has been used as adjuvant therapy for inflammatory bowel disease (IBD). However, the mechanism…”
Get full text

Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway by Wang, Wenwen, Lu, Xiya, Chen, Kan, Xia, Yujing, Lu, Jie, Zhou, Ying-Qun, Fan, Xiaoming, Guo, Chuan-Yong, Xu, Shizan, Liu, Tong, Li, Jingjing, Feng, Jiao, Li, Sainan, Weiqi, Dai, Zhang, Qinghui, Wu, Liwei, Yu, Qiang

“…Background. Hepatic ischemia reperfusion (IR) injury is a common phenomenon in transplantation or trauma. The aim of the present study was to determine the…”
Get full text

Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus by Li, Jingjing, Feng, Jiao, Liu, Tong, Xia, Yujing, Lu, Jie, Guo, Chuan-Yong, Zhou, Ying-Qun, Li, Linqiang, Kong, Rui, Zhou, Shunfeng, Zhou, Yuqing, Li, Sainan, Xu, Shizan, Cheng, Keran, Zhang, Rong, Wu, Liwei

“…Objective. The present study was conducted to compare the efficacy of metformin combined with diammonium glycyrrhizinate enteric-coated capsule (DGEC) versus…”
Get full text

Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy by Xu, Shizan, Li, Jingjing, Li, Sainan, Feng, Jiao, Liu, Tong, Lu, Xiya, Chen, Kan, Xia, Yujing, Lu, Jie, Zhou, Ying-Qun, Guo, Chuan-Yong, Yu, Qiang, Kong, Rui, Cheng, Keran, Li, Linqiang, Zhou, Shunfeng, Zhang, Rong, Dong, Qian, Zhou, Yuqing, Wu, Liwei

“…Aims. To investigate cerebral hemodynamics in cirrhotic patients with HE and to observe effects of treatment in cerebral hemodynamics and correlations among…”
Get full text

Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death by Li, Sainan, Li, Jingjing, Dai, Weiqi, Zhang, Qinghui, Feng, Jiao, Wu, Liwei, Liu, Tong, Yu, Qiang, Xu, Shizan, Wang, Wenwen, Lu, Xiya, Chen, Kan, Xia, Yujing, Lu, Jie, Zhou, Yingqun, Fan, Xiaoming, Mo, Wenhui, Xu, Ling, Guo, Chuanyong

“…Background: Genistein is a natural isoflavone with many health benefits, including antitumour effects. Increased hypoxia-inducible factor 1 α (HIF-1 α ) levels…”
Get full text

In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity by Li, Sainan, Wu, Liwei, Feng, Jiao, Li, Jingjing, Liu, Tong, Zhang, Rong, Xu, Shizan, Cheng, Keran, Zhou, Yuqing, Zhou, Shunfeng, Kong, Rui, Chen, Kan, Wang, Fan, Xia, Yujing, Lu, Jie, Zhou, Yingqun, Dai, Weiqi, Guo, Chuanyong

“…Glycolysis, as an altered cancer cell-intrinsic metabolism, is an essential hallmark of cancer. Phosphofructokinase (PFK) is a metabolic sensor in the…”
Get full text

TGF‐β/Smad and JAK/STAT pathways are involved in the anti‐fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis by Xu, Shizan, Mao, Yuqing, Wu, Jianye, Feng, Jiao, Li, Jingjing, Wu, Liwei, Yu, Qiang, Zhou, Yuting, Zhang, Jie, Chen, Jiaojiao, Ji, Jie, Chen, Kan, Wang, Fan, Dai, Weiqi, Fan, Xiaoming, Guo, Chuanyong

“…Liver fibrosis, a consequence of unhealthy modern lifestyles, has a growing impact on human health, particularly in developed countries. Here, we have explored…”
Get full text

Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice by Lu, Xiya, Liu, Tong, Chen, Kan, Xia, Yujing, Dai, Weiqi, Xu, Shizan, Xu, Ling, Wang, Fan, Wu, Liwei, Li, Jingjing, Li, Sainan, Wang, Wenwen, Yu, Qiang, Feng, Jiao, Fan, Xiaoming, Zhou, Yingqun, Niu, Peiqin, Guo, Chuanyong

“…[Display omitted] •Inflammation, apoptosis and autophagy are involved in acute fulminant hepatitis.•Isorhamnetin is a natural flavonoid compound from sea…”
Get full text

Cafestol preconditioning attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting ERK/PPARγ pathway by Ji, Jie, Wu, Liwei, Feng, Jiao, Mo, Wenhui, Wu, Jianye, Yu, Qiang, Li, Sainan, Zhang, Jie, Dai, Weiqi, Xu, Xuanfu, Mao, Yuqing, Xu, Shizan, Chen, Kan, Li, Jingjing, Guo, Chuanyong

“…•Apoptosis and autophagy play an important role on HIRI.•Cafestol could efficiently attenuate hepatic ischemia reperfusion injury in mice.•The protective…”
Get full text

Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor‐ β 1/Smads pathway through shikonin by Liu, Tong, Xu, Ling, Wang, Chengfen, Chen, Kan, Xia, Yujing, Li, Jingjing, Li, Sainan, Wu, Liwei, Feng, Jiao, Xu, Shizan, Wang, Wenwen, Lu, Xiya, Fan, Xiaoming, Mo, Wenhui, Zhou, Yingqun, Zhao, Yan, Guo, Chuanyong

Get full text

Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor‐β1/Smads pathway through shikonin by Liu, Tong, Xu, Ling, Wang, Chengfen, Chen, Kan, Xia, Yujing, Li, Jingjing, Li, Sainan, Wu, Liwei, Feng, Jiao, Xu, Shizan, Wang, Wenwen, Lu, Xiya, Fan, Xiaoming, Mo, Wenhui, Zhou, Yingqun, Zhao, Yan, Guo, Chuanyong

“…Background and Aim Liver fibrosis is a worldwide clinical challenge during the progression of chronic liver disease to liver cirrhosis. Shikonin is extracted…”
Get full text

The protective effects of shikonin on hepatic ischemia/reperfusion injury are mediated by the activation of the PI3K/Akt pathway by Liu, Tong, Zhang, QingHui, Mo, Wenhui, Yu, Qiang, Xu, Shizan, Li, Jingjing, Li, Sainan, Feng, Jiao, Wu, Liwei, Lu, Xiya, Zhang, Rong, Li, Linqiang, Cheng, Keran, Zhou, Yuqing, Zhou, Shunfeng, Kong, Rui, Wang, Fan, Dai, Weiqi, Chen, Kan, Xia, Yujing, Lu, Jie, Zhou, Yingqun, Zhao, Yan, Guo, Chuanyong

“…Hepatic ischemia/reperfusion (I/R) injury, which can result in severe liver injury and dysfunction, occurs in a variety of conditions such as liver…”
Get full text

Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice by Xu, Shizan, Wu, Liwei, Zhang, Qinghui, Feng, Jiao, Li, Sainan, Li, Jingjing, Liu, Tong, Mo, Wenhui, Wang, Wenwen, Lu, Xiya, Yu, Qiang, Chen, Kan, Xia, Yujing, Lu, Jie, Xu, Ling, Zhou, Yingqun, Fan, Xiaoming, Guo, Chuanyong

“…Propylene glycol alginate sodium sulfate (PSS), a sulfated polysaccharide possesses anti-inflammatory effects. Here, we investigated the effect of PSS on…”
Get full text

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF- beta 1/Smad pathway-mediated inhibition of extracellular matrix and autophagy by Li, Jingjing, Chen, Kan, Li, Sainan, Feng, Jiao, Liu, Tong, Wang, Fan, Zhang, Rong, Xu, Shizan, Zhou, Yuqing, Zhou, Shunfeng, Xia, Yujing, Lu, Jie, Zhou, Yingqun, Guo, Chuanyong

“…Liver fibrosis is a dynamic reversible pathological process in the development of chronic liver disease to cirrhosis. However, the current treatments are not…”
Get full text