Search Results - "Xu, Qingge"

Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state by Ge, Ying, Rybakova, Inna N, Xu, Qingge, Moss, Richard L

“…Cardiac myosin binding protein C (cMyBP-C), bound to the sarcomere's myosin thick filament, plays an important role in the regulation of muscle contraction…”
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Top-Down Quantitative Proteomics Identified Phosphorylation of Cardiac Troponin I as a Candidate Biomarker for Chronic Heart Failure by Zhang, Jiang, Guy, Moltu J, Norman, Holly S, Chen, Yi-Chen, Xu, Qingge, Dong, Xintong, Guner, Huseyin, Wang, Sijian, Kohmoto, Takushi, Young, Ken H, Moss, Richard L, Ge, Ying

“…The rapid increase in the prevalence of chronic heart failure (CHF) worldwide underscores an urgent need to identify biomarkers for the early detection of CHF…”
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Effective Enrichment and Mass Spectrometry Analysis of Phosphopeptides Using Mesoporous Metal Oxide Nanomaterials by Nelson, Cory A, Szczech, Jeannine R, Dooley, Chad J, Xu, Qingge, Lawrence, Matthew J, Zhu, Haoyue, Jin, Song, Ge, Ying

“…Mass spectrometry (MS)-based phosphoproteomics remains challenging due to the low abundance of phosphoproteins and substoichiometric phosphorylation. This…”
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Mesoporous zirconium oxide nanomaterials effectively enrich phosphopeptides for mass spectrometry-based phosphoproteomics by Nelson, Cory A, Szczech, Jeannine R, Xu, Qingge, Lawrence, Mathew J, Jin, Song, Ge, Ying

“…This work represents the first use of mesoporous zirconium oxide nanomaterials for highly effective and selective enrichment of phosphorylated peptides…”
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Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3 by Johnson, Michael, Li, An-Rong, Liu, Jiwen, Fu, Zice, Zhu, Liusheng, Miao, Shichang, Wang, Xuemei, Xu, Qingge, Huang, Alan, Marcus, Andrew, Xu, Feng, Ebsworth, Karen, Sablan, Emmanuel, Danao, Jay, Kumer, Jeff, Dairaghi, Dan, Lawrence, Chris, Sullivan, Tim, Tonn, George, Schall, Thomas, Collins, Tassie, Medina, Julio

“…A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized and their affinity for the receptor evaluated. Compounds were…”
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Discovery of AMG 853, a CRTH2 and DP Dual Antagonist by Liu, Jiwen, Li, An-Rong, Wang, Yingcai, Johnson, Mike G, Su, Yongli, Shen, Wang, Wang, Xuemei, Lively, Sarah, Brown, Matthew, Lai, SuJen, Gonzalez Lopez De Turiso, Felix, Xu, Qingge, Van Lengerich, Bettina, Schmitt, Mike, Fu, Zice, Sun, Ying, Lawlis, Shanna, Seitz, Lisa, Danao, Jay, Wait, Jill, Ye, Qiuping, Tang, Hua Lucy, Grillo, Mark, Collins, Tassie L, Sullivan, Timothy J, Medina, Julio C

“…Prostaglandin D2 (PGD2) plays a key role in mediating allergic reactions seen in asthma, allergic rhinitis, and atopic dermatitis. PGD2 exerts its activity…”
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Optimization of 2-aminothiazole derivatives as CCR4 antagonists by Wang, Xuemei, Xu, Feng, Xu, Qingge, Mahmud, Hossen, Houze, Jonathan, Zhu, Liusheng, Akerman, Michelle, Tonn, George, Tang, Liang, McMaster, Brian E., Dairaghi, Daniel J., Schall, Thomas J., Collins, Tassie L., Medina, Julio C.

“…A series of 2-aminothiazole-derived antagonists of the CCR4 receptor has been synthesized and their affinity for the receptor evaluated using a [125I]TARC…”
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Stereocontrolled Total Synthesis of Alkaloid G via the Oxy-anion Cope Rearrangement and Improved Total Synthesis of (+)-Ajmaline by Wang, Tao, Xu, Qingge, Yu, Peng, Liu, Xiaoxiang, Cook, James M

“…The oxy-anion Cope rearrangement followed by protonation of the enolate which resulted under conditions of kinetic control has been employed to generate the…”
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Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry by Jin, Yutong, Lin, Ziqing, Xu, Qingge, Fu, Cexiong, Zhang, Zhaorui, Zhang, Qunying, Pritts, Wayne A, Ge, Ying

“…The pharmaceutical industry's interest in monoclonal antibodies (mAbs) and their derivatives has spurred rapid growth in the commercial and clinical pipeline…”
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Middle-Down Multi-Attribute Analysis of Antibody-Drug Conjugates with Electron Transfer Dissociation by Chen, Bifan, Lin, Ziqing, Zhu, Yanlong, Jin, Yutong, Larson, Eli, Xu, Qingge, Fu, Cexiong, Zhang, Zhaorui, Zhang, Qunying, Pritts, Wayne A, Ge, Ying

“…Antibody-drug conjugates (ADCs) are designed to combine the target specificity of monoclonal antibodies and potent cytotoxin drugs to achieve better…”
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Top-down Targeted Proteomics for Deep Sequencing of Tropomyosin Isoforms by Peng, Ying, Chen, Xin, Zhang, Han, Xu, Qingge, Hacker, Timothy A, Ge, Ying

“…Tropomyosins (Tm) constitute a family of ubiquitous and highly conserved actin-binding proteins, playing essential roles in a variety of biological processes…”
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Phosphorylation, but Not Alternative Splicing or Proteolytic Degradation, Is Conserved in Human and Mouse Cardiac Troponin T by Zhang, Jiang, Zhang, Han, Ayaz-Guner, Serife, Chen, Yi-Chen, Dong, Xintong, Xu, Qingge, Ge, Ying

“…Cardiac troponin T (cTnT), the tropomyosin binding subunit of the troponin complex, plays a pivotal regulatory role in the Ca2+-mediated interaction between…”
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PP2A-B′ holoenzyme substrate recognition, regulation and role in cytokinesis by Wu, Cheng-Guo, Chen, Hui, Guo, Feng, Yadav, Vikash K, Mcilwain, Sean J, Rowse, Michael, Choudhary, Alka, Lin, Ziqing, Li, Yitong, Gu, Tingjia, Zheng, Aiping, Xu, Qingge, Lee, Woojong, Resch, Eduard, Johnson, Benjamin, Day, Jenny, Ge, Ying, Ong, Irene M, Burkard, Mark E, Ivarsson, Ylva, Xing, Yongna

“…Protein phosphatase 2A (PP2A) is a major Ser/Thr phosphatase; it forms diverse heterotrimeric holoenzymes that counteract kinase actions. Using a peptidome…”
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Top-down high-resolution electron capture dissociation mass spectrometry for comprehensive characterization of post-translational modifications in Rhesus monkey cardiac troponin I by Xu, Fangmin, Xu, Qingge, Dong, Xintong, Guy, Moltu, Guner, Huseyin, Hacker, Timothy A., Ge, Ying

“…▪. ▶ Top-down ECD MS was employed for comprehensively charactering PTMs in monkey cTnI. ▶ Rhesus monkey cTnI was N-terminally acetylated and mono- or…”
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The impact of antibody selection on the detection of cardiac troponin I by Guy, Moltu J., Chen, Yi-Chen, Clinton, Laura, Zhang, Han, Zhang, Jiang, Dong, Xintong, Xu, Qingge, Ayaz-Guner, Serife, Ge, Ying

“…Cardiac troponin I (cTnI) is the current standard biomarker for diagnosing acute myocardial infarction and for risk-stratification of acute coronary syndromes…”
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Delineating Anopheles gambiae coactivator associated arginine methyltransferase 1 automethylation using top–down high resolution tandem mass spectrometry by Kuhn, Peter, Xu, Qingge, Cline, Erika, Zhang, Di, Ge, Ying, Xu, Wei

“…Coactivator‐associated arginine methyltransferase 1 (CARM1), originally defined as a coactivator for steroid receptors, is a member of the protein arginine…”
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Differential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity by Liu, Lin, Hou, Jie, Du, Jiali, Chumanov, Robert S., Xu, Qingge, Ge, Ying, Johnson, Jeffrey A., Murphy, Regina M.

“…Tg2576 mice produce high levels of beta-amyloid (Aβ) and develop amyloid deposits, but lack neurofibrillary tangles and do not suffer the extensive neuronal…”
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Enantiospecific total synthesis of the enantiomer of the indole alkaloid affinisine by Liu, Xiaoxiang, Wang, Tao, Xu, Qingge, Ma, Chunrong, Cook, James M

“…The enantiomer of affinisine has been synthesized (from l-tryptophan) with 100% diastereoselectivity via the asymmetric Pictet–Spengler reaction coupled with a…”
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Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry by Jin, Yutong, Lin, Ziqing, Xu, Qingge, Fu, Cexiong, Zhang, Zhaorui, Zhang, Qunying, Pritts, Wayne A., Ge, Ying

“…The pharmaceutical industry's interest in monoclonal antibodies (mAbs) and their derivatives has spurred rapid growth in the commercial and clinical pipeline…”
Get full text