Search Results - "Xu, Qingfu"

Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model by Verhoeven, David, Xu, Qingfu, Pichichero, Michael E

“…Highlights • A trivalent vaccine, recombinant PcpA, PhtD and PlyD1, was effective in preventing pneumonia. • The trivalent vaccine induced protection of both…”
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Nasopharyngeal bacterial interactions in children by Xu, Qingfu, Almudervar, Anthony, Casey, Janet R, Pichichero, Michael E

“…Antimicrobial treatments and vaccines can alter bacterial interactions in the nasopharynx, thereby altering disease processes. To better understand these…”
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Nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection by Xu, Qingfu, Wischmeyer, Jareth, Gonzalez, Eduardo, Pichichero, Michael E

“…Summary Objectives We sought to understand how polymicrobial colonization varies during health, viral upper respiratory infection (URI) and acute upper…”
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Differential Impact of Respiratory Syncytial Virus and Parainfluenza Virus on the Frequency of Acute Otitis Media Is Explained by Lower Adaptive and Innate Immune Responses in Otitis-Prone Children by Verhoeven, David, Xu, Qingfu, Pichichero, Michael E.

“…Background. Acute otitis media (AOM) is a leading cause of bacterial pediatric infections associated with viral upper respiratory infections (URIs). We…”
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Protection against Streptococcus pneumoniae Invasive Pathogenesis by a Protein-Based Vaccine Is Achieved by Suppression of Nasopharyngeal Bacterial Density during Influenza A Virus Coinfection by Khan, M Nadeem, Xu, Qingfu, Pichichero, Michael E

“…An increase in Streptococcus pneumoniae nasopharynx (NP) colonization density during a viral coinfection initiates pathogenesis. To mimic natural S. pneumoniae…”
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Comparative Analysis of Microbiome in Nasopharynx and Middle Ear in Young Children With Acute Otitis Media by Xu, Qingfu, Gill, Steve, Xu, Lei, Gonzalez, Eduardo, Pichichero, Michael E

“…Acute otitis media (AOM) is the most common pediatric infection for which antibiotics are prescribed in the United States. The role of the respiratory tract…”
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Co-colonization by Haemophilus influenzae with Streptococcus pneumoniae enhances pneumococcal-specific antibody response in young children by Xu, Qingfu, Pichichero, Michael E

“…Highlights • Spn in the NP with Hi or Mcat produces increased antibody responses to Spn candidate vaccine proteins. • Antibody responses to Hi vaccine proteins…”
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Oral vaccination with an adenovirus-vectored vaccine protects against botulism by Chen, Shan, Xu, Qingfu, Zeng, Mingtao

“…Highlights ► An oral vaccine can elicit neutralizing antibody response against botulinum neurotoxin. ► The candidate oral vaccine can protect against lethal…”
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When Co-colonizing the Nasopharynx Haemophilus influenzae Predominates Over Streptococcus pneumoniae Except Serotype 19A Strains to Cause Acute Otitis Media by Xu, Qingfu, Casey, Janet R, Chang, Arthur, Pichichero, Michael E

“…Of 368 acute otitis media (AOM) cases among 7-valent pneumococcal conjugate-vaccinated children, 43.5% were colonized by multiple otopathogens in the…”
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Phylogenetic relatedness and diversity of non-typable Haemophilus influenzae in the nasopharynx and middle ear fluid of children with acute otitis media by KAUR, Ravinder, CHANG, Arthur, QINGFU XU, CASEY, Janet R, PICHICHERO, Michael E

“…The phylogenetic relationships of non-typable Haemophilus influenzae (NTHi) strains prospectively isolated from healthy children and children with acute otitis…”
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Impact of Respiratory Viral Infections on α-Hemolytic Streptococci and Otopathogens in the Nasopharynx of Young Children by Friedel, Victoria, Chang, Arthur, Wills, Jennifer, Vargas, Roberto, Xu, Qingfu, Pichichero, Michael E

“…BACKGROUND:We studied nasopharyngeal (NP) colonization in a cohort of children to determine the impact of viral upper respiratory infections (URIs) on…”
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Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in children by Xu, Qingfu, Pichichero, Michael E, Casey, Janet R, Zeng, Mingtao

“…After our recent discovery of a Streptococcus pneumoniae 19A "superbug" (Legacy strain) that is resistant to all Food and Drug Administration-approved…”
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Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children by Pichichero, Michael E., Kaur, Ravinder, Casey, Janet R., Xu, Qingfu, Almudevar, Anthony, Ochs, Martina

“…We prospectively compared serum antibody levels of 5 Streptococcus pneumoniae (Spn) proteins: PcpA PhtD, PhtE Ply and LytB associated with nasopharyngeal (NP)…”
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Nontypeable Streptococcus pneumoniae as an otopathogen by Xu, Qingfu, Kaur, Ravinder, Casey, Janet R, Sabharwal, Vishakha, Pelton, Stephen, Pichichero, Michael E

“…Abstract Among 34 Streptococcus pneumoniae ( Spn ) sequential isolates from middle ear fluid, we found a case of a nontypeable S. pneumoniae (NT- Spn ) in a…”
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Detoxified Lethal Toxin as a Potential Mucosal Vaccine against Anthrax by Xu, Qingfu, Zeng, Mingtao

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine by Zeng, Mingtao, Xu, Qingfu, Pichichero, Michael E

“…Abstract Human vaccination with BioThrax™ requires six injections followed by annual boosters. This makes it difficult for the compliance of the immunization…”
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Protective Immunity against Tularemia Provided by an Adenovirus-Vectored Vaccine Expressing Tul4 of Francisella tularensis by Kaur, Ravinder, Chen, Shan, Arévalo, Maria T, Xu, Qingfu, Chen, Yanping, Zeng, Mingtao

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine by Zeng, Mingtao, Xu, Qingfu, Elias, Md, Pichichero, Michael E, Simpson, Lance L, Smith, Leonard A

“…Abstract Botulinum neurotoxins cause botulism, a neuroparalytic disease in humans and animals. We constructed a replication-incompetent adenovirus encoding a…”
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N-fragment of edema factor as a candidate antigen for immunization against anthrax by Zeng, Mingtao, Xu, Qingfu, Hesek, Eric D., Pichichero, Michael E.

“…The nontoxic N-terminal fragment of Bacillus anthracis edema factor (EF) was evaluated as a candidate antigen in an anthrax vaccine using a…”
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Transcriptional stimulation of anthrax toxin receptors by anthrax edema toxin and Bacillus anthracis Sterne spore by Xu, Qingfu, Hesek, Eric D., Zeng, Mingtao

“…We used quantitative real-time RT-PCR to not only investigate the mRNA levels of anthrax toxin receptor 1 (ANTXR1) and 2 (ANTXR2) in the murine J774A.1…”
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