Search Results - "Xu, Mingjiang"

Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges by Mathews, Stephanie, Xu, Mingjiang, Wang, Hua, Bertola, Adeline, Gao, Bin

“…Over the last four decades, chronic ethanol feeding studies in rodents using either ad libitum feeding or intragastric infusion models have significantly…”
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Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression by Cimmino, Luisa, Dolgalev, Igor, Wang, Yubao, Yoshimi, Akihide, Martin, Gaëlle H., Wang, Jingjing, Ng, Victor, Xia, Bo, Witkowski, Matthew T., Mitchell-Flack, Marisa, Grillo, Isabella, Bakogianni, Sofia, Ndiaye-Lobry, Delphine, Martín, Miguel Torres, Guillamot, Maria, Banh, Robert S., Xu, Mingjiang, Figueroa, Maria E., Dickins, Ross A., Abdel-Wahab, Omar, Park, Christopher Y., Tsirigos, Aristotelis, Neel, Benjamin G., Aifantis, Iannis

“…Loss-of-function mutations in TET2 occur frequently in patients with clonal hematopoiesis, myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML) and…”
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Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice by Li, Hongliang, Xu, Mingjiang, Lee, Jiyeon, He, Chaoyong, Xie, Zhonglin

“…Leucine supplementation has been shown to prevent high-fat diet (HFD)-induced obesity, hyperglycemia, and dyslipidemia in animal models, but the underlying…”
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Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies by Li, Zhe, Cai, Xiaoqiang, Cai, Chen-Leng, Wang, Jiapeng, Zhang, Wenyong, Petersen, Bruce E., Yang, Feng-Chun, Xu, Mingjiang

“…TET2 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies including MDS, CMML, MPN, and AML. However, little is known regarding…”
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Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies by Yang, Hui, Kurtenbach, Stefan, Guo, Ying, Lohse, Ines, Durante, Michael A., Li, Jianping, Li, Zhaomin, Al-Ali, Hassan, Li, Lingxiao, Chen, Zizhen, Field, Matthew G., Zhang, Peng, Chen, Shi, Yamamoto, Shohei, Li, Zhuo, Zhou, Yuan, Nimer, Stephen D., Harbour, J. William, Wahlestedt, Claes, Xu, Mingjiang, Yang, Feng-Chun

“…Additional Sex Combs-Like 1 (ASXL1) is mutated at a high frequency in all forms of myeloid malignancies associated with poor prognosis. We generated a Vav1…”
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RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells by Guallar, Diana, Bi, Xianju, Pardavila, Jose Angel, Huang, Xin, Saenz, Carmen, Shi, Xianle, Zhou, Hongwei, Faiola, Francesco, Ding, Junjun, Haruehanroengra, Phensinee, Yang, Fan, Li, Dan, Sanchez-Priego, Carlos, Saunders, Arven, Pan, Feng, Valdes, Victor Julian, Kelley, Kevin, Blanco, Miguel G., Chen, Lingyi, Wang, Huayan, Sheng, Jia, Xu, Mingjiang, Fidalgo, Miguel, Shen, Xiaohua, Wang, Jianlong

“…Ten-eleven translocation (TET) proteins play key roles in the regulation of DNA-methylation status by oxidizing 5-methylcytosine (5mC) to generate…”
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The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome by Sozer, Selcuk, Fiel, Maria Isabel, Schiano, Thomas, Xu, Mingjiang, Mascarenhas, John, Hoffman, Ronald

“…Patients with myeloproliferative disorders are at a high risk of developing thrombotic events. Several investigators have hypothesized that endothelial cell…”
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Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies by He, Yonghan, Khan, Sajid, Huo, Zhiguang, Lv, Dongwen, Zhang, Xuan, Liu, Xingui, Yuan, Yaxia, Hromas, Robert, Xu, Mingjiang, Zheng, Guangrong, Zhou, Daohong

“…Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of…”
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Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin‐2 and neutrophil extracellular traps by Li, Hongjie, Feng, Dechun, Cai, Yan, Liu, Yudong, Xu, Mingjiang, Xiang, Xiaogang, Zhou, Zhou, Xia, Qiang, Kaplan, Mariana J., Kong, Xiaoni, Gao, Bin

“…Lipocalin‐2 (LCN2), also known as neutrophil gelatinase‐associated lipocalin (NGAL), a key antibacterial protein, is highly elevated in patients with end‐stage…”
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Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis by Li, Xuekun, Yao, Bing, Chen, Li, Kang, Yunhee, Li, Yujing, Cheng, Ying, Li, Liping, Lin, Li, Wang, Zhiqin, Wang, Mengli, Pan, Feng, Dai, Qing, Zhang, Wei, Wu, Hao, Shu, Qiang, Qin, Zhaohui, He, Chuan, Xu, Mingjiang, Jin, Peng

“…Emerging evidence suggests that active DNA demethylation machinery plays important epigenetic roles in mammalian adult neurogenesis; however, the precise…”
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Loss of Asxl1 leads to myelodysplastic syndrome–like disease in mice by Wang, Jiapeng, Li, Zhaomin, He, Yongzheng, Pan, Feng, Chen, Shi, Rhodes, Steven, Nguyen, Lihn, Yuan, Jin, Jiang, Li, Yang, Xianlin, Weeks, Ophelia, Liu, Ziyue, Zhou, Jiehao, Ni, Hongyu, Cai, Chen-Leng, Xu, Mingjiang, Yang, Feng-Chun

“…ASXL1 is mutated/deleted with high frequencies in multiple forms of myeloid malignancies, and its alterations are associated with poor prognosis. De novo ASXL1…”
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TET1 plays an essential oncogenic role in MLL-rearranged leukemia by Huang, Hao, Jiang, Xi, Li, Zejuan, Li, Yuanyuan, Song, Chun-Xiao, He, Chunjiang, Sun, Miao, Chen, Ping, Gurbuxani, Sandeep, Wang, Jiapeng, Hong, Gia-Ming, Elkahloun, Abdel G., Arnovitz, Stephen, Wang, Jinhua, Szulwach, Keith, Lin, Li, Street, Craig, Wunderlich, Mark, Dawlaty, Meelad, Neilly, Mary Beth, Jaenisch, Rudolf, Yang, Feng-Chun, Mulloy, James C., Jin, Peng, Liu, Paul P., Rowley, Janet D., Xu, Mingjiang, He, Chuan, Chen, Jianjun

“…The ten-eleven translocation 1 (TET1) gene is the founding member of the TET family of enzymes (TET1/2/3) that convert 5-methylcytosine to…”
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Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells by Pan, Feng, Wingo, Thomas S., Zhao, Zhigang, Gao, Rui, Makishima, Hideki, Qu, Guangbo, Lin, Li, Yu, Miao, Ortega, Janice R., Wang, Jiapeng, Nazha, Aziz, Chen, Li, Yao, Bing, Liu, Can, Chen, Shi, Weeks, Ophelia, Ni, Hongyu, Phillips, Brittany Lynn, Huang, Suming, Wang, Jianlong, He, Chuan, Li, Guo-Min, Radivoyevitch, Tomas, Aifantis, Iannis, Maciejewski, Jaroslaw P., Yang, Feng-Chun, Jin, Peng, Xu, Mingjiang

“…TET2 is a dioxygenase that catalyses multiple steps of 5-methylcytosine oxidation. Although TET2 mutations frequently occur in various types of haematological…”
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HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia by Zhu, Ganqian, Luo, Huacheng, Feng, Yang, Guryanova, Olga A., Xu, Jianfeng, Chen, Shi, Lai, Qian, Sharma, Arati, Xu, Bing, Zhao, Zhigang, Feng, Ru, Ni, Hongyu, Claxton, David, Guo, Ying, Mesa, Ruben A., Qiu, Yi, Yang, Feng-Chun, Li, Wei, Nimer, Stephen D., Huang, Suming, Xu, Mingjiang

“…Nucleophosmin ( NPM1 ) is the most commonly mutated gene in acute myeloid leukemia (AML) resulting in aberrant cytoplasmic translocation of the encoded…”
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Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses by Huang, Zhuqi, Shen, Sirui, Han, Xue, Li, Weixin, Luo, Wu, Lin, Liming, Xu, Mingjiang, Wang, Yi, Huang, Weijian, Wu, Gaojun, Liang, Guang

“…Atherosclerosis is a chronic inflammatory disease with high morbidity and mortality rates worldwide. Doublecortin‐like kinase 1 (DCLK1), a…”
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Upregulation of a Disintegrin and Metalloproteinase With Thrombospondin Motifs-7 by miR-29 Repression Mediates Vascular Smooth Muscle Calcification by Du, Yaoyao, Gao, Cheng, Liu, Ziyi, Wang, Li, Liu, Bo, He, Fan, Zhang, Tao, Wang, Yue, Wang, Xiujie, Xu, Mingjiang, Luo, Guan-Zheng, Zhu, Yi, Xu, Qingbo, Wang, Xian, Kong, Wei

“…OBJECTIVE—Vascular calcification significantly increases cardiovascular morbidity and mortality. We recently reported that the deficiency of cartilage…”
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Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia by Chu, Yajing, Chen, Yangpeng, Li, Mengke, Shi, Deyang, Wang, Bichen, Lian, Yu, Cheng, Xuelian, Wang, Xiaomin, Xu, Mingjiang, Cheng, Tao, Shi, Jun, Yuan, Weiping

“…Molecular genetic changes in acute myeloid leukemia (AML) play crucial roles in leukemogenesis, including recurrent chromosome translocations,…”
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Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice by Zhao, Zhigang, Chen, Li, Dawlaty, Meelad M., Pan, Feng, Weeks, Ophelia, Zhou, Yuan, Cao, Zeng, Shi, Hui, Wang, Jiapeng, Lin, Li, Chen, Shi, Yuan, Weiping, Qin, Zhaohui, Ni, Hongyu, Nimer, Stephen D., Yang, Feng-Chun, Jaenisch, Rudolf, Jin, Peng, Xu, Mingjiang

“…TET1/2/3 are methylcytosine dioxygenases that regulate cytosine hydroxymethylation. Tet1/2 are abundantly expressed in HSC/HPCs and are implicated in…”
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Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo by Guo, Ying, Yang, Hui, Chen, Shi, Zhang, Peng, Li, Rong, Nimer, Stephen D., Harbour, J. William, Xu, Mingjiang, Yang, Feng-Chun

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Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy by Zhang, Peng, He, Fuhong, Bai, Jie, Yamamoto, Shohei, Chen, Shi, Zhang, Lin, Sheng, Mengyao, Zhang, Lei, Guo, Ying, Man, Na, Yang, Hui, Wang, Suyun, Cheng, Tao, Nimer, Stephen D, Zhou, Yuan, Xu, Mingjiang, Wang, Qian-Fei, Yang, Feng-Chun

“…ASXL1 is frequently mutated in myeloid malignancies and is known to co-occur with other gene mutations. However, the molecular mechanisms underlying the…”
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