Search Results - "Xu, Ligeng"

Emerging nanomedicine approaches fighting tumor metastasis: animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy by Liang, Chao, Xu, Ligeng, Song, Guosheng, Liu, Zhuang

“…Metastasis is directly or indirectly responsible for the majority of cancer deaths. Anti-metastasis treatment is thus the key to cure cancer. Recent…”
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Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy by Chen, Qian, Xu, Ligeng, Liang, Chao, Wang, Chao, Peng, Rui, Liu, Zhuang

“…A therapeutic strategy that can eliminate primary tumours, inhibit metastases, and prevent tumour relapses is developed herein by combining adjuvant…”
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A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy by Xu, Jun, Lv, Jia, Zhuang, Qi, Yang, Zongjin, Cao, Zhiqin, Xu, Ligeng, Pei, Pei, Wang, Chenya, Wu, Hanfei, Dong, Ziliang, Chao, Yu, Wang, Chao, Yang, Kai, Peng, Rui, Cheng, Yiyun, Liu, Zhuang

“…Cancer metastases and recurrence after surgical resection remain an important cause of treatment failure. Here we demonstrate a general strategy to fabricate…”
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Nanoparticle‐Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy by Chen, Qian, Chen, Jiawen, Yang, Zhijuan, Xu, Jun, Xu, Ligeng, Liang, Chao, Han, Xiao, Liu, Zhuang

“…External radiotherapy is extensively used in clinic to destruct tumors by locally applied ionizing‐radiation beams. However, the efficacy of radiotherapy is…”
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Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses by Yang, Guangbao, Xu, Ligeng, Chao, Yu, Xu, Jun, Sun, Xiaoqi, Wu, Yifan, Peng, Rui, Liu, Zhuang

“…Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO 2 ) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging…”
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Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses by Chao, Yu, Xu, Ligeng, Liang, Chao, Feng, Liangzhu, Xu, Jun, Dong, Ziliang, Tian, Longlong, Yi, Xuan, Yang, Kai, Liu, Zhuang

“…Radiation therapy for cancer can lead to off-target toxicity and can be ineffective against hypoxic solid tumours and distant metastases. Here, we show that…”
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Light‐Triggered In Situ Gelation to Enable Robust Photodynamic‐Immunotherapy by Repeated Stimulations by Meng, Zhouqi, Zhou, Xuanfang, Xu, Jun, Han, Xiao, Dong, Ziliang, Wang, Hairong, Zhang, Yaojia, She, Jialin, Xu, Ligeng, Wang, Chao, Liu, Zhuang

“…Photodynamic therapy (PDT) has shown the potential of triggering systemic antitumor immune responses. However, while the oxygen‐deficient hypoxic tumor…”
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Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy by Hu, Mengying, Wang, Ying, Xu, Ligeng, An, Sai, Tang, Yu, Zhou, Xuefei, Li, Jingjing, Liu, Rihe, Huang, Leaf

“…Activated hepatic stellate cell (aHSC)-mediated liver fibrosis is essential to the development of liver metastasis. Here, we discover intra-hepatic scale-up of…”
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Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods by Qiu, Yang, Liu, Ying, Wang, Liming, Xu, Ligeng, Bai, Ru, Ji, Yinglu, Wu, Xiaochun, Zhao, Yuliang, Li, Yufeng, Chen, Chunying

“…Abstract Gold nanorods (Au NRs) have been recognized as promising materials for biomedical applications, like sensing, imaging, gene and drug delivery and…”
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One-pot synthesis of pH-responsive charge-switchable PEGylated nanoscale coordination polymers for improved cancer therapy by Yang, Yu, Xu, Ligeng, Zhu, Wenjun, Feng, Liangzhu, Liu, Jingjing, Chen, Qian, Dong, Ziliang, Zhao, Jiayue, Liu, Zhuang, Chen, Meiwan

“…Nanoscale coordination polymers (NCPs) are promising nanomedicine platforms featured with biodegradability and versatile functionalities. However, multi-step…”
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Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy by Wang, Liming, Liu, Ying, Li, Wei, Jiang, Xiumei, Ji, Yinglu, Wu, Xiaochun, Xu, Ligeng, Qiu, Yang, Zhao, Kai, Wei, Taotao, Li, Yufeng, Zhao, Yuliang, Chen, Chunying

“…We have observed that Au nanorods (NRs) have distinct effects on cell viability via killing cancer cells while posing negligible impact on normal cells and…”
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Dual-functional Se/Fe complex facilitates TRAIL treatment against resistant tumor cells via modulating cellular endoplasmic reticulum stress by Yang, Yahui, Wang, Yifan, Xu, Ligeng, Chen, Tianfeng

“…Fe complex introduced with selenium (Se/Fe) shows great synergistic effects with TRAIL agonist treatment through modulating ER-stress related selenoproteins,…”
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Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment by Xu, Ligeng, Liu, Ye, Chen, Zhiyun, Li, Wei, Liu, Ying, Wang, Liming, Liu, Yong, Wu, Xiaochun, Ji, Yinglu, Zhao, Yuliang, Ma, Liying, Shao, Yiming, Chen, Chunying

“…With the intense international response to the AIDS pandemic, HIV vaccines have been extensively investigated but have failed due to issues of safety or…”
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Dual-Aptamer Modification Generates a Unique Interface for Highly Sensitive and Specific Electrochemical Detection of Tumor Cells by Qu, Liming, Xu, Jinhai, Tan, Xiaofang, Liu, Zhuang, Xu, Ligeng, Peng, Rui

“…Because circulating tumor cells (CTCs) have been proven to be an important clue of the tumor metastasis, their detection thus plays a pivotal role in the…”
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Metabolic Reprogramming of NK Cells by Black Phosphorus Quantum Dots Potentiates Cancer Immunotherapy by He, Lizhen, Zhao, Jianfu, Li, Hongjun, Xie, Bin, Xu, Ligeng, Huang, Guanning, Liu, Ting, Gu, Zhen, Chen, Tianfeng

“…Low persistence, metabolic dysfunction in microenvironment, and tumor‐derived immunosuppression of Natural killer (NK) cells in patients are greatly limited…”
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Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells by Fang, Shuai, Wang, Chao, Xiang, Jian, Cheng, Liang, Song, Xuejiao, Xu, Ligeng, Peng, Rui, Liu, Zhuang

“…Detection of circulating tumor cells （CTCs） plays an important role in cancer diagnosis and prognosis. In this study, aptamer-conjugated upconversion nano-…”
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Universal selenium nanoadjuvant with immunopotentiating and redox-shaping activities inducing high-quality immunity for SARS-CoV-2 vaccine by Lai, Haoqiang, Xu, Ligeng, Liu, Chang, Shi, Sujiang, Jiang, Yalin, Yu, Yangyang, Deng, Bo, Chen, Tianfeng

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Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination by Yang, Rong, Xu, Jun, Xu, Ligeng, Sun, Xiaoqi, Chen, Qian, Zhao, Yuhuan, Peng, Rui, Liu, Zhuang

“…Tumor vaccines for cancer prevention and treatment have attracted tremendous interests in the area of cancer immunotherapy in recent years. In this work, we…”
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Ruthenium complexes boost NK cell immunotherapy via sensitizing triple-negative breast cancer and shaping immuno-microenvironment by Chen, Qi, He, Lizhen, Li, Xiaoying, Xu, Ligeng, Chen, Tianfeng

“…Discovery of effective chemical sensitizers to synergize with natural killer cells immunotherapy is urgently desired to overcome its unsatisfactory efficacy in…”
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Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer by Xu, Jun, Xu, Ligeng, Wang, Chenya, Yang, Rong, Zhuang, Qi, Han, Xiao, Dong, Ziliang, Zhu, Wenwen, Peng, Rui, Liu, Zhuang

“…While immunotherapy has become a highly promising paradigm for cancer treatment in recent years, it has long been recognized that photodynamic therapy (PDT)…”
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