Search Results - "Xu, Jianrui"

Tie2cre-Induced Inactivation of the miRNA-Processing Enzyme Dicer Disrupts Invariant Nkt Cell Development by Zhou, Li, Seo, Kook-Heon, He, Hong-Zhi, Pacholczyk, Rafal, Meng, Dong-Mei, Li, Chang-Gui, Xu, Jianrui, She, Jin-Xiong, Dong, Zheng, Mi, Qing-Sheng, Marrack, Philippa

“…MicroRNAs (miRNAs) are a class of evolutionarily conserved small noncoding RNAs that are increasingly being recognized as important regulators of gene…”
Get full text

Aromatic amino acid activation of signaling pathways in bone marrow mesenchymal stem cells depends on oxygen tension by El Refaey, Mona, Zhong, Qing, Hill, William D, Shi, Xing-Ming, Hamrick, Mark W, Bailey, Lakiea, Johnson, Maribeth, Xu, Jianrui, Bollag, Wendy B, Chutkan, Norman, Isales, Carlos M

“…The physiologic oxygen pressures inside the bone marrow environment are much lower than what is present in the peripheral circulation, ranging from 1-7%,…”
Get full text

Multiple melanocortin receptors are expressed in bone cells by Zhong, Qing, Sridhar, Supriya, Ruan, Ling, Ding, Ke-Hong, Xie, Ding, Insogna, Karl, Kang, Baolin, Xu, Jianrui, Bollag, Roni J., Isales, Carlos M.

“…Melanocortin receptors belong to the seven transmembrane domain, G-protein coupled family of receptors. There are five members of this receptor family labeled…”
Get full text

Loss of microRNAs in thymus perturbs invariant NKT cell development and function by Seo, Kook-Heon, Zhou, Li, Meng, Dongmei, Xu, Jianrui, Dong, Zhong, Mi, Qing-Sheng

“…microRNAs (miRNAs) are small noncoding RNAs that mediate RNA interference to suppress protein expression at the translational level. Accumulated evidence…”
Get full text

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss by Refaey, Mona El, McGee‐Lawrence, Meghan E, Fulzele, Sadanand, Kennedy, Eileen J, Bollag, Wendy B, Elsalanty, Mohammed, Zhong, Qing, Ding, Ke‐Hong, Bendzunas, Nathaniel G, Shi, Xing‐ming, Xu, Jianrui, Hill, William D, Johnson, Maribeth H, Hunter, Monte, Pierce, Jessica L, Yu, Kanglun, Hamrick, Mark W, Isales, Carlos M

“…ABSTRACT Age‐dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably…”
Get full text

Estrogen deficiency from ovariectomy enhances the formation of osteocyte plasma membrane disruptions from treadmill exercise in vivo by Vinson, Brooke, Xu, Jianrui, Ding, Kehong, Elsalanty, Mohammed, Isales, Carlos M, McGee‐Lawrence, Meghan E

“…Plasma membrane disruptions (PMD) form in cortical bone osteocytes with mechanical loading, and may be involved in mechanisms underlying how osteocytes sense…”
Get full text

Kynurenine Induces Renal Fibrosis which May Contribute to Bone Loss in Aging by Irsik, Debra L, Xu, Jianrui, Bollag, Wendy B, Isales, Carlos M.

“…Aging results in both bone loss and renal dysfunction, and the two conditions are interrelated. Low‐protein diets are recommended to increase longevity in the…”
Get full text

Tryptophan Depletion through a Low Protein Diet Alters Renal Structure and Function in Young Male Mice by Irsik, Debra L., Xu, Jianrui, Kang, Baolin, Zhong, Qing, Ding, Kehong, McGee-Lawrence, Meghan, Bollag, Wendy B., Isales, Carlos M.

“…Abstract only Low protein diets have been used in patients with chronic kidney disease to decrease uremic burden, but its use is controversial due to concerns…”
Get full text

Carboxy-terminal PTH fragments stimulate [ 3H]thymidine incorporation in vascular endothelial cells by Ding, Ke-Hong, Zhong, Qing, Xie, Ding, Xu, Jianrui, Bollag, Roni J., Bollag, Wendy B., Isales, Carlos M.

“…We have previously reported that the intact PTH molecule (1–84) stimulates proliferation of human umbilical vein endothelial cells (HUVECs). To define the…”
Get full text

Amino acids as signaling molecules modulating bone turnover by Ding, Ke-Hong, Cain, Michael, Davis, Michael, Bergson, Clare, McGee-Lawrence, Meghan, Perkins, Crystal, Hardigan, Trevor, Shi, Xingming, Zhong, Qing, Xu, Jianrui, Bollag, Wendy B., Hill, William, Elsalanty, Mohammed, Hunter, Monte, Isales, Maria C., Lopez, Patricia, Hamrick, Mark, Isales, Carlos M.

“…Except for the essential amino acids (AAs), much of the focus on adequate dietary protein intake has been on total nitrogen and caloric intake rather than AA…”
Get full text

Prenatal Exposure to MAM Impairs mPFC and Hippocampal Inhibitory Function in Mice during Adolescence and Adulthood by He, Zhiyin, He, Qian, Tang, Xiaorong, Huang, Keni, Lin, Yiwen, Xu, Jianrui, Chen, Qiliang, Xu, Nenggui, Yao, Lulu

“…Neurodevelopmental abnormalities are considered to be one of the important causes of schizophrenia. The offspring of methylazoxymethanol acetate (MAM)–exposed…”
Get full text

Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells by El Refaey, Mona, Watkins, Christopher P., Kennedy, Eileen J., Chang, Andrew, Zhong, Qing, Ding, Ke-Hong, Shi, Xing-ming, Xu, Jianrui, Bollag, Wendy B., Hill, William D., Johnson, Maribeth, Hunter, Monte, Hamrick, Mark W., Isales, Carlos M.

“…•The aromatic amino acids activate proliferative and differentiation pathways in bone marrow mesenchymal stem cells.•Oxidized amino acids are either less…”
Get full text

The glucocorticoid receptor in osteoprogenitors regulates bone mass and marrow fat by Pierce, Jessica L, Ding, Ke-Hong, Xu, Jianrui, Sharma, Anuj K, Yu, Kanglun, del Mazo Arbona, Natalia, Rodríguez-Santos, Zuleika, Bernard, Paul J, Bollag, Wendy B, Johnson, Maribeth H, Hamrick, Mark W, Begun, Dana L, Shi, Xing-Ming, Isales, Carlos M, McGee-Lawrence, Meghan E

“…Excess fat within bone marrow is associated with lower bone density. Metabolic stressors such as chronic caloric restriction (CR) can exacerbate marrow…”
Get full text

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity by Ding, Kehong, McGee-Lawrence, Meghan E., Kaiser, Helen, Sharma, Anuj K., Pierce, Jessica L., Irsik, Debra L., Bollag, Wendy B., Xu, Jianrui, Zhong, Qing, Hill, William, Shi, Xing-Ming, Fulzele, Sadanand, Kennedy, Eileen J., Elsalanty, Mohammed, Hamrick, Mark W., Isales, Carlos M.

“…Tryptophan is an essential amino acid catabolized initially to kynurenine (kyn), an immunomodulatory metabolite that we have previously shown to promote bone…”
Get full text

Monomethylfumarate protects against ovariectomy-related changes in body composition by Bollag, Anna E, Guo, Tianyang, Ding, Ke-Hong, Choudhary, Vivek, Chen, Xunsheng, Zhong, Qing, Xu, Jianrui, Yu, Kanglun, Awad, Mohamed E, Elsalanty, Mohammed, Johnson, Maribeth H, McGee-Lawrence, Meghan E, Bollag, Wendy B, Isales, Carlos M

“…Osteoporosis, low bone mass that increases fracture susceptibility, affects approximately 75 million individuals in the United States, Europe and Japan, with…”
Get full text

Deletion of protein kinase D1 in osteoprogenitor cells results in decreased osteogenesis in vitro and reduced bone mineral density in vivo by Bollag, Wendy B., Choudhary, Vivek, Zhong, Qing, Ding, Ke-Hong, Xu, Jianrui, Elsayed, Ranya, Yu, Kanglun, Su, Yun, Bailey, Lakiea J., Shi, Xing-Ming, Elsalanty, Mohammed, Johnson, Maribeth H., McGee-Lawrence, Meghan E., Isales, Carlos M.

“…Protein kinase D1 (PRKD1) is thought to play a role in a number of cellular functions, including proliferation and differentiation. We hypothesized that PRKD1…”
Get full text

Dietary Kynurenine, the oxidized metabolite of tryptophan, suppresses osteoprogenitor expression of Hdac3 resulting in increased marrow adiposity and age‐related bone loss by McGee‐Lawrence, Meghan, Pierce, Jessica, Yu, Kanglun, Davis, Colleen, Dukes, Amy, Zhong, Qing, Xu, Jianrui, Bollag, Wendy, Elsalanty, Mohammed, Kennedy, Eileen, Ding, Kehong, Hill, William, Hamrick, Mark W, Isales, Carlos

“…Abstract only Background Aging results in loss of skeletal bone mass resulting in osteoporosis and increased marrow fat although the mechanism remains poorly…”
Get full text

Protein kinase D1 conditional null mice show minimal bone loss following ovariectomy by Bollag, Wendy B., Ding, Ke-Hong, Choudhary, Vivek, Xu, Jianrui, Zhong, Qing, Elsayed, Ranya, Bailey, Lakiea J., Elsalanty, Mohammed, Yu, Kanglun, Johnson, Maribeth H., McGee-Lawrence, Meghan E., Isales, Carlos M.

“…We previously found that 3- and 6-month-old male mice with conditional ablation of protein kinase D1 (PRKD1) in osteoprogenitor cells (expressing Osterix)…”
Get full text

Loss of Indoleamine-2,3-Dioxygenase-1 (IDO1) in Knockout Mice Does Not Affect the Development of Skin Lesions in the Imiquimod-Induced Mouse Model of Psoriasis by Choudhary, Vivek, Ajebo, Etsubdenk, Uaratanawong, Rawipan, Spaulding, Shinjini C, Hossack, Sarah, Chen, Xunsheng, Xu, Jianrui, Choudhary, Mrunal, Irsik, Debra L, Isales, Carlos M, Bollag, Wendy B

“…Indoleamine-2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan resulting in tryptophan depletion and the accumulation of catabolites such as…”
Get full text

Impact of Dietary Aromatic Amino Acids on Osteoclastic Activity by Refaey, Mona El, Zhong, Qing, Ding, Ke-Hong, Shi, Xing-ming, Xu, Jianrui, Bollag, Wendy B., Hill, William D., Chutkan, Norman, Robbins, Richard, Nadeau, Hugh, Johnson, Maribeth, Hamrick, Mark W., Isales, Carlos M.

“…We had shown that aromatic amino acid (phenylalanine, tyrosine, and tryptophan) supplementation prevented bone loss in an aging C57BL/6 mice model. In vivo…”
Get full text