Search Results - "Xu, Jianchao"

Total Synthesis of Daptomycin by Cyclization via a Chemoselective Serine Ligation by Lam, Hiu Yung, Zhang, Yinfeng, Liu, Han, Xu, Jianchao, Wong, Clarence T. T, Xu, Ci, Li, Xuechen

“…A total synthesis of daptomycin, the first natural product antibiotic launched in a generation, was achieved. This convergent synthesis relies on an efficient…”
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Construction of diverse peptide structural architectures via chemoselective peptide ligation by Cheung, Carina Hey Pui, Xu, Jianchao, Lee, Chi Lung, Zhang, Yanfeng, Wei, Ruohan, Bierer, Donald, Huang, Xuhui, Li, Xuechen

“…Herein, we report the development of a facile synthetic strategy for constructing diverse peptide structural architectures chemoselective peptide ligation. The…”
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Renalase deficiency aggravates ischemic myocardial damage by Wu, Yanling, Xu, Jianchao, Velazquez, Heino, Wang, Peili, Li, Guoyong, Liu, Dinggang, Sampaio-Maia, Benedita, Quelhas-Santos, Janete, Russell, Kerry, Russell, Raymond, Flavell, Richard A., Pestana, Manuel, Giordano, Frank, Desir, Gary V.

“…Chronic kidney disease (CKD) leads to an 18-fold increase in cardiovascular complications not fully explained by traditional risk factors. Levels of renalase,…”
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Effects of Second Phases on Microstructure, Microhardness, and Corrosion Behavior of Mg-3Sn-(1Ca) Alloys by Wang, Chunming, Guo, Shuai, Zeng, Luming, Zheng, Desen, Xu, Jianchao, Yang, Munan, Liang, Tongxiang

“…The effects of second phases on microstructure, microhardness, and corrosion behavior of aged Mg-3Sn (T3) and Mg-3Sn-1Ca (TX31) alloys are investigated…”
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Catecholamines Regulate the Activity, Secretion, and Synthesis of Renalase by GUOYONG LI, JIANCHAO XU, PEILI WANG, VELAZQUEZ, Heino, YANYAN LI, YANLING WU, DESIR, Gary V

“…We previously identified renalase, a secreted novel amine oxidase that specifically degrades circulating catecholamines. Parenteral administration of either…”
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Adhesive chitosan-based hybrid biohydrogels for peripheral nerve injury repair by Qiu, Pengjia, Wang, Lei, Wang, Jing, Wang, Xingdong, Xu, Jianchao, An, Xiaokai, Han, Fengwang, Dong, Zhao, Zhang, Jiangtao, Shi, Peiwen, Niu, Qiang

“…With the rapid progress of industrialization, the incidence of peripheral nerve injuries caused by trauma has been continuously increasing. These injuries…”
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Experimental and Analytical Studies of U-Shaped Thin-Walled RC Beams Under Combined Actions of Torsion, Flexure and Shear by Xu, Jianchao, Chen, Shenggang, Guo, Quanquan, Ye, Yinghua, Diao, Bo, Mo, Y. L.

“…U-shaped thin-walled concrete bridge beams usually suffer the combined actions of flexure, shear and torsion, but no research about the behavior of U-shaped…”
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Synthesis and biological evaluation of novel 2-arylamino-3-(arylsulfonyl)quinoxalines as PI3Kα inhibitors by Wu, Peng, Su, Yi, Liu, Xiaowen, Zhang, Lei, Ye, Yong, Xu, Jianchao, Weng, Shaoyu, Li, Yani, Liu, Tao, Huang, Shufang, Yang, Bo, He, Qiaojun, Hu, Yongzhou

“…A series of novel 2-arylamino-3-(arylsulfonyl)quinoxalines was synthesized through a newly developed approach. All synthesized target compounds were screened…”
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Parametric Study on Mixed Torsional Behavior of U-Shaped Thin-Walled RC Girders by Mo, Y. L., Ye, Yinghua, Guo, Quanquan, Diao, Bo, Xu, Jianchao, Zhou, Tianmin

“…Nowadays, U-shaped thin-walled concrete girders have been widely applied in the urban construction of rail viaducts in China as well as worldwide. However, the…”
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Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII by Li, Yanyan, Wang, Peili, Xu, Jianchao, Gorelick, Fred, Yamazaki, Hanae, Andrews, Norma, Desir, Gary V.

“…Insulin regulates blood glucose by promoting uptake by fat and muscle, and inhibiting production by liver. Insulin-stimulated glucose uptake is mediated by…”
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The Voltage-Gated Potassium Channel Kv1.3 Regulates Peripheral Insulin Sensitivity by Xu, Jianchao, Wang, Peili, Li, Yanyan, Li, Guoyong, Kaczmarek, Leonard K., Wu, Yanling, Koni, Pandelakis A., Flavell, Richard A., Desir, Gary V., Giebisch, Gerhard

“…Kv1.3 is a voltage-gated potassium (K) channel expressed in a number of tissues, including fat and skeletal muscle. Channel inhibition improves experimental…”
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Flavonoids as vasorelaxant agents: synthesis, biological evaluation and quantitative structure activities relationship (QSAR) studies by Dong, Xiaowu, Wang, Yanming, Liu, Tao, Wu, Peng, Gao, Jiadi, Xu, Jianchao, Yang, Bo, Hu, Yongzhou

“…A series of 2-(2-diethylamino)-ethoxychalcone and 6-prenyl(or its isomers)-flavanones 10a,b and 11a-g were synthesized and evaluated for their vasorelaxant…”
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The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight by Xu, Jianchao, Koni, Pandelakis A., Wang, Peili, Li, Guoyong, Kaczmarek, Leonard, Wu, Yanling, Li, Yanyan, Flavell, Richard A., Desir, Gary V.

“…Voltage-gated potassium (Kv) channels regulate cell membrane potential and control a variety of cellular processes. Kv1.3 channels are expressed in several…”
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Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism by Li, Yanyan, Wang, Peili, Xu, Jianchao, Desir, Gary V

“…Kv1.3 is a voltage-gated K(+) channel expressed in insulin-sensitive tissues. We previously showed that gene inactivation or pharmacological inhibition of…”
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Reducing Visit-To-Visit Variability in Systolic Blood Pressure for Improving the Progression of Carotid Atherosclerosis and Endothelial Dysfunction in Patients with Hypertension Management by Song, Hongbin, Liu, Zhendong, Zhao, Yingxin, Ye, Lin, Lu, Fanghong, Zhang, Hua, Diao, Yutao, Xu, Jianchao

“…Visit-to-visit variability (VVV) in blood pressure (BP) creates challenges to hypertension control and was independent associated with increased all-cause…”
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Probabilistic fatigue life prediction for RC beams under chloride environment considering the statistical uncertainty by Bayesian updating by Wu, Jieqiong, Zhang, Bochao, Xu, Jianchao, Jin, Liu, Diao, Bo

“…•A probabilistic S-N curve incorporating chloride attack for RC beams is proposed.•Statistical uncertainty due to model parameters is considered by Bayesian…”
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Impacts of reinforcement ratio and fatigue load level on the chloride ingress and service life estimating of fatigue loaded reinforced concrete (RC) beams by Wu, Jieqiong, Xu, Jianchao, Diao, Bo, Panesar, Daman K.

“…•Cl- ingress and service life are analyzed with reinforcement ratios and load levels.•Fatigue loads with high values expedite the Cl- ingress of compressive…”
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Effects of the reinforcement ratio and chloride corrosion on the fatigue behavior of RC beams by Wu, Jieqiong, Diao, Bo, Xu, Jianchao, Zhang, Runxiao, Zhang, Wuman

“…•RC beams with a 2.91% reinforcement ratio exhibit nonlinear fatigue behavior.•Pre-fatigue damage and Cl- corrosion accelerate the degradation of RC…”
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Effects of pre-fatigue damage on high-cycle fatigue behavior and chloride permeability of RC beams by Wu, Jieqiong, Zhang, Runxiao, Diao, Bo, Zhang, Wuman, Xu, Jianchao

“…•High cycle fatigue behaviors and chloride permeability of RC beams are investigated.•Chloride content at steel bar surface markedly increases at loading…”
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Experimental study and reliability assessment of fatigue loaded reinforced concrete beams combined with chloride exposure by Xu, Jianchao, Zhao, Tibo, Wu, Jieqiong, Diao, Bo

“…•Combined actions of pre-fatigue loading (∼0.2% − 30%Nu) and Cl- exposure are tested.•Main crack widths decrease after 3 months of Cl- exposure but increase…”
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