Search Results - "Xu, Huixiong"

Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice by Yue, Wenwen, Chen, Liang, Yu, Luodan, Zhou, Bangguo, Yin, Haohao, Ren, Weiwei, Liu, Chang, Guo, Lehang, Zhang, Yifeng, Sun, Liping, Zhang, Kun, Xu, Huixiong, Chen, Yu

“…Combined checkpoint blockade (e.g., PD1/PD-L1) with traditional clinical therapies can be hampered by side effects and low tumour-therapeutic outcome,…”
Get full text

Sono‐Controllable and ROS‐Sensitive CRISPR‐Cas9 Genome Editing for Augmented/Synergistic Ultrasound Tumor Nanotherapy by Pu, Yinying, Yin, Haohao, Dong, Caihong, Xiang, Huijing, Wu, Wencheng, Zhou, Bangguo, Du, Dou, Chen, Yu, Xu, Huixiong

“…The potential of the cluster regularly interspaced short palindromic repeat (CRISPR)‐associated protein 9 (Cas9)‐based therapeutic genome editing is severely…”
Get full text

Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis by Guan, Xin, Sun, Liping, Shen, Yuting, Jin, Fengshan, Bo, Xiaowan, Zhu, Chunyan, Han, Xiaoxia, Li, Xiaolong, Chen, Yu, Xu, Huixiong, Yue, Wenwen

“…Cancer recurrence after surgical resection (SR) is a considerable challenge, and the biological effect of SR on the tumor microenvironment (TME) that is…”
Get full text

Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy by Gao, Jing, Hou, Bo, Zhu, Qiwen, Yang, Lei, Jiang, Xingyu, Zou, Zhifeng, Li, Xutong, Xu, Tianfeng, Zheng, Mingyue, Chen, Yi-Hung, Xu, Zhiai, Xu, Huixiong, Yu, Haijun

“…PROteolysis TArgeting Chimeras (PROTACs) has been exploited to degrade putative protein targets. However, the antitumor performance of PROTACs is impaired by…”
Get full text

Ultrasmall Cu2-xS Nanodots for Highly Efficient Photoacoustic Imaging-Guided Photothermal Therapy by Mou, Juan, Li, Pei, Liu, Chengbo, Xu, Huixiong, Song, Liang, Wang, Jin, Zhang, Kun, Chen, Yu, Shi, Jianlin, Chen, Hangrong

“…Monodisperse, ultrasmall (<5 nm) Cu2−xS nanodots (u‐Cu2−xS NDs) with significantly strong near‐infrared absorption and conversion are successfully demonstrated…”
Get full text

Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence by Zhang, Kun, Fang, Yan, He, Yaping, Yin, Haohao, Guan, Xin, Pu, Yinying, Zhou, Bangguo, Yue, Wenwen, Ren, Weiwei, Du, Dou, Li, Hongyan, Liu, Chang, Sun, Liping, Chen, Yu, Xu, Huixiong

“…Despite the efficacy of current starvation therapies, they are often associated with some intrinsic drawbacks such as poor persistence, facile tumor metastasis…”
Get full text

Construction of Nucleus‐Targeting Iridium Nanocrystals for Photonic Hyperthermia‐Synergized Cancer Radiotherapy by Wang, Liying, Zhang, Tingting, Huo, Minfeng, Guo, Jia, Chen, Yu, Xu, Huixiong

“…Prominent tumor‐cell nucleus targeting of radiosensitizer substantially affects the therapeutic consequence of advanced tumor radiotherapy via lethal nucleus…”
Get full text

Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis by Zhang, Yan, Yin, Yifei, Zhang, Wei, Li, Hongyan, Wang, Taixia, Yin, Haohao, Sun, Liping, Su, Chunxia, Zhang, Kun, Xu, Huixiong

“…Abstract Background As one typical cardiovascular disease, atherosclerosis severely endanger people’ life and cause burden to people health and mentality. It…”
Get full text

Perfluoropentane-Encapsulated Hollow Mesoporous Prussian Blue Nanocubes for Activated Ultrasound Imaging and Photothermal Therapy of Cancer by Jia, Xiaoqing, Cai, Xiaojun, Chen, Yu, Wang, Shige, Xu, Huixiong, Zhang, Kun, Ma, Ming, Wu, Huixia, Shi, Jianlin, Chen, Hangrong

“…Hollow mesoporous nanomaterials have gained tremendous attention in the fields of nanomedicine and nanobiotechnology. Herein, n-perfluoropentane…”
Get full text

Multi-Source Transfer Learning Via Multi-Kernel Support Vector Machine Plus for B-Mode Ultrasound-Based Computer-Aided Diagnosis of Liver Cancers by Zhang, Huili, Guo, Lehang, Wang, Dan, Wang, Jun, Bao, Lili, Ying, Shihui, Xu, Huixiong, Shi, Jun

“…B-mode ultrasound (BUS) imaging is a routine tool for diagnosis of liver cancers, while contrast-enhanced ultrasound (CEUS) provides additional information to…”
Get full text

Design of a self-driven probiotic-CRISPR/Cas9 nanosystem for sono-immunometabolic cancer therapy by Yu, Jifeng, Zhou, Bangguo, Zhang, Shen, Yin, Haohao, Sun, Liping, Pu, Yinying, Zhou, Boyang, Sun, Yikang, Li, Xiaolong, Fang, Yan, Wang, Lifan, Zhao, Chongke, Du, Dou, Zhang, Yan, Xu, Huixiong

“…Reprogramming the tumor immunosuppressive microenvironment is a promising strategy for improving tumor immunotherapy efficacy. The clustered regularly…”
Get full text

A Drug-Perfluorocarbon Nanoemulsion with an Ultrathin Silica Coating for the Synergistic Effect of Chemotherapy and Ablation by High-Intensity Focused Ultrasound by Ma, Ming, Xu, Huixiong, Chen, Hangrong, Jia, Xiaoqing, Zhang, Kun, Wang, Qi, Zheng, Shuguang, Wu, Rong, Yao, Minghua, Cai, Xiaojun, Li, Faqi, Shi, Jianlin

“…The synergistic effect of chemotherapy and ablation using high‐intensity focused ultrasound (HIFU) is realized with a newly developed drug‐delivery system. The…”
Get full text

Contrast-enhanced ultrasound imaging of the liver: a review of the clinical evidence for SonoVue and Sonazoid by Barr, Richard G., Huang, Pintong, Luo, Yan, Xie, Xiaoyan, Zheng, Rongqin, Yan, Kun, Jing, Xiang, Luo, Yukun, Xu, Huixiong, Fei, Xiang, Lee, Jeong Min

“…Contrast-enhanced ultrasound (CEUS) has become an established modality in various clinical indications for liver diseases. SonoVue ® , a pure blood pure agent,…”
Get full text

BRAFV600E mutation in papillary thyroid microcarcinoma: a meta-analysis by Li, Fei, Chen, Guangqi, Sheng, Chunjun, Gusdon, Aaron M, Huang, Yueye, Lv, Zhongwei, Xu, Huixiong, Xing, Mingzhao, Qu, Shen

“…The prognostic value of the BRAFV600E mutation, resulting in poor clinical outcomes of papillary thyroid carcinoma, has been generally confirmed. However, the…”
Get full text

Comparison Study of Radiomics and Deep Learning Based Methods for Thyroid Nodules Classification Using Ultrasound Images by Wang, Yongfeng, Yue, Wenwen, LI, Xiaolong, Liu, Shuyu, Guo, Lehang, Xu, Huixiong, Zhang, Heye, Yang, Guang

“…Thyroid nodules have a high prevalence and a small percentage is malignant. Many non-invasive methods have been developed with the help of the Internet of…”
Get full text

Nanomedicine‐Enabled Photonic Thermogaseous Cancer Therapy by Yin, Haohao, Guan, Xin, Lin, Han, Pu, Yinying, Fang, Yan, Yue, Wenwen, Zhou, Bangguo, Wang, Qiao, Chen, Yu, Xu, Huixiong

“…Local photothermal hyperthermia for tumor ablation and specific stimuliresponsive gas therapy feature the merits of remote operation, noninvasive intervention,…”
Get full text

A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy by Gao, Jing, Jiang, Xingyu, Lei, Shumin, Cheng, Wenhao, Lai, Yi, Li, Min, Yang, Lei, Liu, Peifeng, Chen, Xiao-hua, Huang, Min, Yu, Haijun, Xu, Huixiong, Xu, Zhiai

“…The antitumor performance of PROteolysis-TArgeting Chimeras (PROTACs) is limited by its insufficient tumor specificity and poor pharmacokinetics. These…”
Get full text

Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers by An, Liwei, Cao, Zhifa, Nie, Pingping, Zhang, Hui, Tong, Zhenzhu, Chen, Fan, Tang, Yang, Han, Yi, Wang, Wenjia, Zhao, Zhangting, Zhao, Qingya, Yang, Yuqin, Xu, Yuanzhi, Fang, Gemin, Shi, Lei, Xu, Huixiong, Ma, Haiqing, Jiao, Shi, Zhou, Zhaocai

“…The striatin-interacting phosphatase and kinase (STRIPAK) complexes integrate extracellular stimuli that result in intracellular activities. Previously, we…”
Get full text

A continuous tri-phase transition effect for HIFU-mediated intravenous drug delivery by Zhang, Kun, Chen, Hangrong, Li, Faqi, Wang, Qi, Zheng, Shuguang, Xu, Huixiong, Ma, Ming, Jia, Xiaoqing, Chen, Yu, Mou, Juan, Wang, Xia, Shi, Jianlin

“…Abstract Aiming at substantially enhanced efficacy and biosafety of clinical HIFU therapy, a natural solid medium, L-menthol (LM), characteristic of mild and…”
Get full text

Biodegradable and Excretable 2D W1.33C i‐MXene with Vacancy Ordering for Theory‐Oriented Cancer Nanotheranostics in Near‐Infrared Biowindow by Zhou, Bangguo, Yin, Haohao, Dong, Caihong, Sun, Liping, Feng, Wei, Pu, Yinying, Han, Xiaoxia, Li, Xiaolong, Du, Dou, Xu, Huixiong, Chen, Yu

“…MXenes, a new class of two‐dimensional (2D) nanomaterials, have shown enormous potential for biological applications. Notably, the development of 2D MXenes in…”
Get full text