Search Results - "Xu, Hongjiang"

D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics by Lu, Jianguang, Xu, Hongjiang, Xia, Jianghua, Ma, Jie, Xu, Jun, Li, Yanan, Feng, Jun

“…The transition of antimicrobial peptides (AMPs) from the laboratory to market has been severely hindered by their instability toward proteases in biological…”
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A quantitative method for determination of colistin E2 methanesulphonate in human plasma by 15N-labeled colistin E2 by Xu, Hongjiang, Li, Yanan, Zhang, Jing, Zhang, Jinhua, Lu, Jianguang, Zhang, Xiquan, Yang, Ling, Zhao, Wenjie, Feng, Jun

“…The single-component colistin E2, with superior antibacterial activity and lower toxicity, was being developed as the latest generation of polymyxin drugs…”
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Synthesis and biological evaluation of esterified and acylated derivatives of NH2-(AEEA)5-amphotericin B by Zhang, Jinhua, Dong, Yuanzhen, Xu, Hongjiang, Chen, Minwei, Tang, Hanqing, Shangguan, Wenwen, Zhao, Wenjie, Feng, Jun

“…Based on NH 2 -(AEEA) 5 -amphotericin B ( DMR005 ; AEEA is 8-amino-3,6-dioxaoctanoic acid), a series of novel esterified and acylated derivatives of DMR005…”
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Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization by Xie, Hui, Zeng, Lili, Zeng, Shaogao, Lu, Xin, Zhang, Guicheng, Zhao, Xin, Cheng, Na, Tu, Zhengchao, Li, Zhiyuan, Xu, Hongjiang, Yang, Ling, Zhang, Xiquan, Huang, Min, Zhao, Junling, Hu, Wenhui

“…We previously reported a highly potent DPP-IV inhibitor 6 with low in vivo efficacy. While trying to maintain consistent in vitro and in vivo biological…”
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Data quality issues in implementing an ERP by Xu, Hongjiang, Horn Nord, Jeretta, Brown, Noel, Daryl Nord, G

“…Data quality is a critical issue during the implementation of an enterprise resource planning (ERP) system. Data quality problems can have a significant impact…”
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Users’ perception of cybersecurity, trust and cloud computing providers’ performance by Xu, Hongjiang, Mahenthiran, Sakthi

“…Purpose This study aims to develop a scale to measure the cloud provider’s performance and it investigates the factors that impact that performance from the…”
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CYBERSECURITY AND DATA QUALITY'S IMPACT ON CLOUD ERP

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Design, synthesis, and biological evaluation of a potential long-acting glucagon-like peptide-1 (GLP-1) analog by Zhang, Jinhua, Xu, Hongjiang, Lu, Jianguang, Dong, Yuanzhen, Feng, Jun

“…[Display omitted] •The side chains included the same two fatty acids and two fatty acids of different type and length.•Two fatty acids of the side chains had a…”
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RESEARCH FRAMEWORK OF HUMAN FACTORS INTERACTIONS WITH TECHNICAL AND SECURITY FACTORS IN CLOUD COMPUTING

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Development of a thermally responsive nanogel based on chitosan-poly(N-isopropylacrylamide-co-acrylamide) for paclitaxel delivery by Wang, Yajing, Xu, Hongjiang, Wang, Jiu, Ge, Liang, Zhu, Jiabi

“…A thermally responsive nanogel was developed through the radical polymerization based on chitosan (CTS) and N-isopropylacrylamide (NIPAAm) with acrylamide…”
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Long-Term Strategies for Poorly Water-Soluble Peptides: Combining Fatty Acid Modification with PAS Fusion by Zhu, Hongxiang, Hua, Haoju, Dong, Yanzhen, Zhang, Jinhua, Xu, Hongjiang, Ge, Xingfeng, Lu, Qin, Feng, Jun

“…Bulevirtide, an entry inhibitor for the hepatitis B virus (HBV) and hepatitis D virus (HDV), is currently available on the European market. However, its…”
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Discovery of 4‑Aminoquinoline-3-carboxamide Derivatives as Potent Reversible Bruton’s Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis by Yao, Xia, Sun, Xiuyun, Jin, Shuyu, Yang, Ling, Xu, Hongjiang, Rao, Yu

“…A structure-hopping strategy was applied to discover a series of novel 4-aminoquinoline-3-carboxamide derivatives as potent, reversible BTK inhibitors…”
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Design of a novel long-acting dual GLP-1/GIP receptor agonist by Dong, Yuanzhen, Zhang, Jinhua, Xu, Hongjiang, Shen, Hengqiao, Lu, Qin, Feng, Jun, Cai, Zhengyan

“…[Display omitted] Tirzepatide, the first approved dual GLP-1/GIP receptor agonist (RA), has achieved better clinical outcomes than other GLP-1RAs. However, it…”
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6,7-Dimorpholinoalkoxy quinazoline derivatives as potent EGFR inhibitors with enhanced antiproliferative activities against tumor cells by Zhang, Yaling, Chen, Li, Xu, Hongjiang, Li, Xiabing, Zhao, Lijun, Wang, Wei, Li, Baolin, Zhang, Xiquan

“…A series of novel 6,7-dimorpholinoalkoxy quinazoline derivatives was designed, synthesized and evaluated as potent EGFR inhibitors. Most of synthesized…”
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Magnesium isoglycyrrhizinate prevents cadmium-induced activation of JNK and apoptotic hepatocyte death by reversing ROS-inactivated PP2A by Chen, Xiaoling, Wang, Xiaoxue, Yang, Liu, Xu, Hongjiang, Wu, Yiqun, Wu, Jialin, Chen, Long, Xu, Chong

“…Cadmium (Cd) induces reactive oxygen species (ROS)-mediated hepatocyte apoptosis and consequential liver disorders. This study aimed to investigate the effect…”
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Discovery, optimization and biological evaluation of novel HBsAg production inhibitors by Zhang, Li, Ge, Xingfeng, Jin, Hui, Lu, Dandan, Chen, Shuo, Zhang, Yang, Wang, Xiaojin, Xu, Hongjiang, Ao, Wangwei, Zhang, Yinsheng

“…Hepatitis B virus (HBV) infection is a major global health problem. HBsAg inhibitors are expected to reduce the production of HBsAg via inhibiting host…”
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Discovery of imidazo[1,2-b]pyridazine macrocyclic derivatives as novel ALK inhibitors capable of combating multiple resistant mutants by Xiao, Xiaofei, Xu, Yunsheng, Yu, Xihua, Chen, Yinbo, Zhao, Weiwei, Xie, Zhendong, Zhu, Xueyan, Xu, Hongjiang, Yang, Yulei, Zhang, Peng

“…[Display omitted] Anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitor (TKI) often loses effectiveness against non-small cell lung malignancies (NSCLCs)…”
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Design, synthesis and biological evaluation of novel N-(methyl-d3) pyridazine-3-carboxamide derivatives as TYK2 inhibitors by Liu, Fei, Wang, Bin, Liu, Yanlong, Shi, Wei, Hu, Zhongyuan, Chang, Xiayun, Tang, Xujing, Zhang, Ying, Xu, Hongjiang, He, Ying

“…[Display omitted] As a mediator of pro-inflammatory cytokines, TYK2 is an attractive target to treat autoimmunity diseases. Herein, we reported the design,…”
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Design, synthesis and biological evaluation of a novel N-aminoacyl derivative of amphotericin B methyl ester as an antifungal agent by Zhang, Jinhua, Xu, Hongjiang, Dong, Yuanzhen, Chen, Minwei, Zhang, You, Shangguan, Wenwen, Zhao, Wenjie, Feng, Jun

“…[Display omitted]…”
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Ameliorative effect of Magnesium Isoglycyrrhizinate on hepatic encephalopathy by Epirubicin by Jiang, Wenjiao, Guo, Huijie, Su, Dongyuan, Xu, Hongjiang, Gu, Hongmei, Hao, Kun

“…The purpose of the present study was to evaluate the protective effect of Magnesium Isoglycyrrhizinate (MI) on Epirubicin (EPI)-induced hepatic encephalopathy…”
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