Search Results - "Xu, Gui‐Lian"

LIGHT aggravates sepsis‐associated acute kidney injury via TLR4‐MyD88‐NF‐κB pathway by Zhong, Yu, Wu, Shun, Yang, Yan, Li, Gui‐qing, Meng, Li, Zheng, Quan‐you, Li, You, Xu, Gui‐lian, Zhang, Ke‐qin, Peng, Kan‐fu

“…Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical critical care syndrome. It has received increasing attention due to its high morbidity and…”
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Complement C5a/C5aR pathway potentiates the pathogenesis of gastric cancer by down-regulating p21 expression by Chen, Jian, Li, Gui-qing, Zhang, Li, Tang, Ming, Cao, Xu, Xu, Gui-lian, Wu, Yu-Zhang

“…Although the complement C5a/C5aR pathway is suggested to play a critical role in tumor pathogenesis, the underlying mechanism has yet to be fully elucidated…”
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C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression by Xu, Gui‐lian, Chen, Jian, Yang, Fei, Li, Gui‐qing, Zheng, Li‐xin, Wu, Yu‐zhang

“…Viral fulminant hepatitis (FH) remains a serious clinical problem with very high mortality. Lacking understanding of FH pathogenesis has in essence hindered…”
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C5a/C5aR1 mediates IMQ‐induced psoriasiform skin inflammation by promoting IL‐17A production from γδ‐T cells by Zheng, Quan‐you, Xu, Feng, Yang, Yi, Sun, Dao‐dong, Zhong, Yu, Wu, Shun, Li, Gui‐qing, Gao, Wei‐wu, Wang, Tao, Xu, Gui‐lian, Liang, Shen‐ju

“…Psoriasis is a chronic relapsing inflammatory skin disease, affecting up to 3% of the global population. Accumulating evidence suggests that the complement…”
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Increased expression of Fibrinogen-Like Protein 2 is associated with poor prognosis in patients with clear cell renal cell carcinoma by Tang, Ming, Cao, Xu, Li, Peng, Zhang, Kun, Li, You, Zheng, Quan-you, Li, Gui-qing, Chen, Jian, Xu, Gui-lian, Zhang, Ke-qin

“…Fibrinogen-like protein 2 (FGL2) is highly expressed in various tumour tissues and plays a vital role in tumour initiation and progression. This study…”
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Bone Marrow Mesenchymal Stem Cells Exert Protective Effects After Ischemic Stroke Through Upregulation of Glutathione by Lan, Xiao-Yan, Sun, Zheng-Wu, Xu, Gui-Lian, Chu, Cheng-Yan, Qin, Hua-Min, Li, Shen, Geng, Xin, Gao, Peng, Boltze, Johannes, Li, Shen

“…Bone marrow mesenchymal stem cells (BMSCs) have been shown to promote stroke recovery, however, the underlying mechanisms are not well understood. In this…”
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LIGHT/IFN‐γ triggers β cells apoptosis via NF‐κB/Bcl2‐dependent mitochondrial pathway by Zheng, Quan‐You, Cao, Zhao‐Hui, Hu, Xiao‐Bo, Li, Gui‐Qing, Dong, Shi‐Fang, Xu, Gui‐Lian, Zhang, Ke‐Qin

“…LIGHT recruits and activates naive T cells in the islets at the onset of diabetes. IFN‐γ secreted by activated T lymphocytes is involved in beta cell…”
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STAT1-mediated down-regulation of Bcl-2 expression is involved in IFN-γ/TNF-α-induced apoptosis in NIT-1 cells by Cao, Zhao-hui, Zheng, Quan-you, Li, Gui-qing, Hu, Xiao-bo, Feng, Shao-long, Xu, Gui-lian, Zhang, Ke-qin

“…Tumor necrosis factor (TNF)-α and interferon (IFN)-γ are the major pro-inflammatory cytokines involved in beta-cell destruction. The fate of islet beta-cells…”
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Fibrinogen-like protein 2 deficiency aggravates renal fibrosis by facilitating macrophage polarization by Wu, Shun, Li, Meng, Xu, Feng, Li, Gui-qing, Han, Bo, He, Xian-dong, Li, Shu-jing, He, Qian-hui, Lai, Xin-yue, Zhou, Shuo, Zheng, Quan-you, Guo, Bo, Chen, Jian, Zhang, Ke-qin, Xu, Gui-lian

“…•Fgl2 Expression is increased in the fibrotic kidney tissues.•Fgl2 deficiency aggravates UUO-induced renal fibrosis.•Fgl2 deficiency promotes UUO-induced…”
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C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis by Zheng, Quan-You, Liang, Shen-Ju, Xu, Feng, Li, Gui-Qing, Luo, Na, Wu, Shun, Li, You, Tang, Ming, Zhong, Yu, Chen, Jian, Yang, Di, Sun, Dao-Dong, Zhang, Ke-Qin, Xu, Gui-Lian

“…Psoriasis is one of the most common chronic inflammatory skin diseases, affecting ~2% of the population. The lack of characterization of the pathogenesis of…”
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C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression by Zhang, Kun, Li, Gui-qing, He, Qian-hui, Li, You, Tang, Ming, Zheng, Quan-you, Xu, Gui-lian, Zhang, Ke-qin

“…Recent reports indicate that the complement C5a/C5aR pathway and progranulin (PGRN) deficiency both contribute to ischemia-reperfusion (IR)-induced acute…”
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Celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression by Tang, Ming, Cao, Xu, Zhang, Kun, Li, You, Zheng, Quan-you, Li, Gui-qing, He, Qian-hui, Li, Shu-jing, Xu, Gui-lian, Zhang, Ke-qin

“…Renal fibrosis is the final manifestation of various chronic kidney diseases, and no effective therapy is available to prevent or reverse it. Celastrol, a…”
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LIGHT deficiency aggravates cisplatin-induced acute kidney injury by upregulating mitochondrial apoptosis by Yang, Yan, Meng, Li, Wu, Shun, Li, You, Zhong, Yu, Xu, Feng, Zhou, Xiao-cui, Li, Gui-qing, Xu, Gui-lian, Peng, Kan-fu

“…•Expression of LIGHT and its receptors HVEM and LTβR was increased in kidney tissues of mice after cisplatin treatment.•LIGHT deficiency aggravated…”
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Growth of G422 glioma implanted in the mouse brain was affected by the immune ability of the host by Cheng, Ying-xin, Li, Fei, Lu, Jia-you, Li, Mei, Du, Peng, Xu, Gui-lian, Feng, Hua

“…Background It is generally accepted that gliomas are the most common primary brain tumors with poor prognosis. We aimed to explore the relationship of the…”
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Complement component 3 prevents imiquimod-induced psoriatic skin inflammation by inhibiting apoptosis in mice by Zheng, Quan-you, Liang, Shen-ju, Xu, Feng, Yang, Yi, Feng, Jian-li, Shen, Fen, Zhong, Yu, Wu, Shun, Shu, Yong, Sun, Dao-dong, Xu, Gui-lian

“…•Complement component 3 deficiency exacerbated murine psoriatic skin inflammation.•Absence of complement component 3 caused more imiquimod-induced skin cell…”
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Tumor necrosis factor superfamily 14 is critical for the development of renal fibrosis by Li, You, Tang, Ming, Han, Bo, Wu, Shun, Li, Shu-Jing, He, Qian-Hui, Xu, Feng, Li, Gui-Qing, Zhang, Kun, Cao, Xu, Zheng, Quan-You, Chen, Jian, Yang, Di, Xu, Gui-Lian, Zhang, Ke-Qin

“…Tumor necrosis factor superfamily protein 14 (TNFSF14) was recently identified as a risk factor in some fibrosis diseases. However, the role of TNFSF14 in…”
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C5aR deficiency attenuates the breast cancer development via the p38/p21 axis by Chen, Jian, Sun, Zi-Han, Chen, Li-Ying, Xu, Feng, Zhao, Yun-Pei, Li, Gui-Qing, Tang, Ming, Li, You, Zheng, Quan-You, Wang, Shu-Feng, Yang, Xin-Hua, Wu, Yu-Zhang, Xu, Gui-Lian

“…Emerging evidence has shown activation of the complement component C5 to C5a in cancer tissues and C5aR expression in breast cancer cells relates to the tumor…”
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LIGHT deficiency attenuates acute kidney disease development in an in vivo experimental renal ischemia and reperfusion injury model by Zheng, Quan-you, Li, You, Liang, Shen-ju, Chen, Xi-ming, Tang, Ming, Rao, Zheng-sheng, Li, Gui-qing, Feng, Jian-Li, Zhong, Yu, Chen, Jian, Xu, Gui-lian, Zhang, Ke-qin

“…Ischemia-reperfusion (I/R), a leading risk factor of acute kidney injury (AKI), is associated with high mortality and risk of progression to chronic kidney…”
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Caspase-3 is Involved in IFN-γ- and TNF-α-Mediated MIN6 Cells Apoptosis via NF-κB/Bcl-2 Pathway by Cao, Zhao-hui, Yin, Wei-dong, Zheng, Quan-you, Feng, Shao-long, Xu, Gui-lian, Zhang, Ke-qin

“…TNF-α and IFN-γ are the major pro-inflammatory cytokines in the β-cell destruction. However, the underlying mechanism remains unclear. The present study used a…”
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Complement component 3 deficiency prolongs MHC-II disparate skin allograft survival by increasing the CD4+ CD25+ regulatory T cells population by Zheng, Quan-you, Liang, Shen-ju, Li, Gui-qing, Lv, Yan-bo, Li, You, Tang, Ming, Zhang, Kun, Xu, Gui-lian, Zhang, Ke-qin

“…Recent reports suggest that complement system contributes to allograft rejection. However, its underlying mechanism is poorly understood. Herein, we…”
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