Search Results - "Xu, Fred. Y."

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells by Alizadeh, Javad, Zeki, Amir A., Mirzaei, Nima, Tewary, Sandipan, Rezaei Moghadam, Adel, Glogowska, Aleksandra, Nagakannan, Pandian, Eftekharpour, Eftekhar, Wiechec, Emilia, Gordon, Joseph W., Xu, Fred. Y., Field, Jared T., Yoneda, Ken Y., Kenyon, Nicholas J., Hashemi, Mohammad, Hatch, Grant M., Hombach-Klonisch, Sabine, Klonisch, Thomas, Ghavami, Saeid

“…The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP)…”
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HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells by Hombach‐Klonisch, Sabine, Kalantari, Forouh, Medapati, Manoj Reddy, Natarajan, Suchitra, Krishnan, Sai Nivedita, Kumar‐Kanojia, Aditya, Thanasupawat, Thatchawan, Begum, Farhana, Xu, Fred Y., Hatch, Grant M., Los, Marek, Klonisch, Thomas

“…Poly(ADP‐ribose) polymerase 1 inhibitors alone or in combination with DNA damaging agents are promising clinical drugs in the treatment of cancer. However,…”
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Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1) by Lu, Biao, Xu, Fred Y, Jiang, Yan J, Choy, Patrick C, Hatch, Grant M, Grunfeld, Carl, Feingold, Kenneth R

“…Cardiolipin (CL) is a phospholipid localized to the mitochondria, and its biosynthesis is essential for mitochondrial structure and function. We report here…”
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Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart by MULLIGAN, Christopher M, SPARAGNA, Genevieve C, HATCH, Grant M, MCCUNE, Sylvia A, MOORE, Russell L, CHICCO, Adam J, LE, Catherine H, DE MOOY, Anthony B, ROUTH, Melissa A, HOLMES, Michael G, HICKSON-BICK, Diane L, ZARINI, Simona, MURPHY, Robert C, XU, Fred Y

“…Cardiolipin (CL) is a tetra-acyl phospholipid that provides structural and functional support to several proteins in the inner mitochondrial membrane. The…”
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Cloning and characterization of murine 1-acyl- sn -glycerol 3-phosphate acyltransferases and their regulation by PPARα in murine heart by LU, Biao, JIANG, Yan J., ZHOU, Yaling, XU, Fred Y., HATCH, Grant M., CHOY, Patrick C.

“…AGPAT (1-acyl-sn-glycerol 3-phosphate acyltransferase) exists in at least five isoforms in humans, termed as AGPAT1, AGPAT2, AGPAT3, AGPAT4 and AGPAT5…”
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FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells by Hatch, Grant M, Smith, Anne J, Xu, Fred Y, Hall, Angela M, Bernlohr, David A

“…Biosynthesis of lipids was investigated in growing 293 cells stably expressing fatty acid (FA) transport protein 1 (FATP1), a bifunctional polypeptide with FA…”
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Glucose Uptake and Triacylglycerol Synthesis Are Increased in Barth Syndrome Lymphoblasts by Mejia, Edgard M., Zinko, James C., Hauff, Kristin D., Xu, Fred Y., Ravandi, Amir, Hatch, Grant M.

“…Barth syndrome (BTHS) is an X-linked genetic disease resulting in loss of cardiolipin (Ptd 2 Gro). Patients may be predisposed to hypoglycemia and exhibit…”
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Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells by Xu, Fred Y, Taylor, William A, Hurd, Jeffrey A, Hatch, Grant M

“…We examined the effect of etomoxir treatment on de novo cardiolipin (CL) biosynthesis in H9c2 cardiac myoblast cells. Etomoxir treatment did not affect the…”
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The mevalonate cascade as a target to suppress extracellular matrix synthesis by human airway smooth muscle by Schaafsma, Dedmer, Dueck, Gordon, Ghavami, Saeid, Kroeker, Andrea, Mutawe, Mark M, Hauff, Kristin, Xu, Fred Y, McNeill, Karol D, Unruh, Helmut, Hatch, Grant M, Halayko, Andrew J

“…Smooth muscle cells promote fibroproliferative airway remodeling in asthma, and transforming growth factor β1 (TGFβ1) is a key inductive signal. Statins are…”
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HMGA 2 as a functional antagonist of PARP 1 inhibitors in tumor cells by Hombach‐Klonisch, Sabine, Kalantari, Forouh, Medapati, Manoj Reddy, Natarajan, Suchitra, Krishnan, Sai Nivedita, Kumar‐Kanojia, Aditya, Thanasupawat, Thatchawan, Begum, Farhana, Xu, Fred Y., Hatch, Grant M., Los, Marek, Klonisch, Thomas

“…Poly(ADP‐ribose) polymerase 1 inhibitors alone or in combination with DNA damaging agents are promising clinical drugs in the treatment of cancer. However,…”
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The dynamics of cardiolipin synthesis post-mitochondrial fusion by Xu, Fred Y., McBride, Heidi, Acehan, Devrim, Vaz, Frédéric M., Houtkooper, Riekelt H., Lee, Raymond M., Mowat, Michael A., Hatch, Grant M.

“…Alteration in mitochondrial fusion may regulate mitochondrial metabolism. Since the phospholipid cardiolipin (CL) is required for function of the mitochondrial…”
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On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration by Webster, Jennifer, Jiang, Jenny Y, Lu, Biao, Xu, Fred Y, Taylor, William A, Mymin, Mathew, Zhang, Manna, Minuk, Gerald Y, Hatch, Grant M

“…CL (cardiolipin) is a major mitochondrial membrane phospholipid important for the regulation of mitochondrial function. We examined CL de novo biosynthesis and…”
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Mifepristone Treatment Results in Differential Regulation of Glycerolipid Biosynthesis in Baby Hamster Kidney Cells Expressing a Mifepristone-Inducible ABCA1 by Hauff, Kristin D., Mitchell, Ryan W., Xu, Fred Y., Dembinski, Thomas, Mymin, David, Zha, Xiaohui, Choy, Patrick C., Hatch, Grant M.

“…ATP binding cassette A1 (ABCA1) transports cholesterol, phospholipids and lipophilic molecules to and across cellular membranes. We examined if ABCA1…”
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Cardiolipin Synthase-1 mRNA Expression Does Not Correlate with Endogenous Cardiolipin Synthase Enzyme Activity In Vitro and In Vivo in Mammalian Lipopolysaccharide Models of Inflammation by Lu, Biao, Xu, Fred Y., Taylor, William A., Feingold, Kenneth R., Hatch, Grant M.

“…We examined if lipopolysaccharide (LPS) treatment of mice affected cardiolipin (CL) synthesis. Mice were injected i.p. with LPS, the liver harvested, and CL…”
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StARD13(Dlc-2) RhoGap mediates ceramide activation of phosphatidylglycerolphosphate synthase and drug response in Chinese hamster ovary cells by Hatch, Grant M, Gu, Yuan, Xu, Fred Y, Cizeau, Jeannick, Neumann, Shannon, Park, Ji-Seon, Loewen, Shauna, Mowat, Michael R A

“…To identify genes involved in etoposide drug response, we used promoter trap mutagenesis to isolate an etoposide-resistant Chinese hamster ovary (CHO) cell…”
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Stimulation of cardiac cardiolipin biosynthesis by PPARα activation by Jiang, Yan J., Lu, Biao, Xu, Fred Y., Gartshore, Jennifer, Taylor, William A., Halayko, Andrew J., Gonzalez, Frank J., Takasaki, Jun, Choy, Patrick C., Hatch, Grant M.

“…The role of peroxisome proliferator-activated receptor α (PPARα)-stimulated phospholipase A2 (PLA2) in cardiac mitochondrial cardiolipin (CL) biosynthesis was…”
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Lysophosphatidylethanolamine acyltransferase activity is elevated during cardiac cell differentiation by Fotheringham, Julie, Xu, Fred Y, Nemer, Mona, Kardami, Elissavet, Choy, Patrick C, Hatch, Grant M

“…We examined if elevation in lysophosphatidylethanolamine acyltransferase activity was associated with elevation in phosphatidylethanolamine content during…”
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On the mechanism of the phospholipase C-mediated attenuation of cardiolipin biosynthesis in H9c2 cardiac myoblast cells by Xu, F Y, Kelly, S L, Taylor, W A, Hatch, G M

“…The effect of phospholipase C treatment on cardiolipin biosynthesis was investigated in intact H9c2 cardiac myoblasts. Treatment of cells with…”
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RhoGAP mediates ceramide activation of phosphatidylglycerolphosphate synthase and drug response in Chinese hamster ovary cells by Hatch, Grant Michael, Gu, Yuan, Xu, Fred Y, Cizeau, Jeannick, Neumann, Shannon, Park, Ji‐Seon, Loewen, Shauna, Mowat, Michael R. A.

“…Promoter trap mutagenesis was used to isolate an etoposide resistant CHO cell line. This resistant CHO‐K1 line, named E91, showed cross resistance to…”
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The phospholipidosis-lnducing potential of the chemopotentiating drug, N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene) correlates with its stimulation of phosphatidylserine synthesis and exposure on the plasma membrane in MCF-7 breast cancer cells by Xu, Fred Y, Queen, Gary, Brandes, Lorne, Hatch, Grant M

“…N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE, tesmilifene), a potent chemopotentiating drug currently in Phase III clinical trials of metastatic…”
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