Search Results - "Xu, Fengwen"
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MARCH8 inhibits influenza A virus infection by targeting viral M2 protein for ubiquitination-dependent degradation in lysosomes
Published in Nature communications (20-07-2021)“…The membrane-associated RING-CH (MARCH) proteins are E3 ligases that regulate the stability of various cellular membrane proteins. MARCH8 has been reported to…”
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The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection
Published in Cell host & microbe (16-10-2013)“…The interferon-inducible myxovirus resistance (Mx) proteins play important roles in combating a wide range of virus infections. MxA inhibits many RNA and DNA…”
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A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
Published in Cell reports (Cambridge) (05-01-2021)“…The cyclic GMP-AMP (cGAMP) synthase (cGAS) is a key DNA sensor that initiates STING-dependent signaling to produce type I interferons through synthesizing the…”
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SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation
Published in PLoS genetics (01-07-2015)“…The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses and long interspersed element 1 (LINE-1). Given that in dividing…”
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CRISPR-Cas13a Inhibits HIV-1 Infection
Published in Molecular therapy. Nucleic acids (04-09-2020)“…CRISPR-Cas provides bacteria and archaea with immunity against invading phages and foreign plasmid DNA and has been successfully adapted for gene editing in a…”
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Residual Immunity from Smallpox Vaccination and Possible Protection from Mpox, China
Published in Emerging infectious diseases (01-02-2024)“…Among persons born in China before 1980 and tested for vaccinia virus Tiantan strain (VVT), 28.7% (137/478) had neutralizing antibodies, 71.4% (25/35) had…”
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SERINC5 restricts influenza virus infectivity
Published in PLoS pathogens (12-10-2022)“…SERINC5 is a multi-span transmembrane protein that is incorporated into HIV-1 particles in producing cells and inhibits HIV-1 entry. Multiple retroviruses like…”
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IFITM3 Inhibits SARS-CoV-2 Infection and Is Associated with COVID-19 Susceptibility
Published in Viruses (01-11-2022)“…SARS-CoV-2 has become a global threat to public health. Infected individuals can be asymptomatic or develop mild to severe symptoms, including pneumonia,…”
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BST-2 restricts IAV release and is countered by the viral M2 protein
Published in Biochemical journal (01-03-2017)“…BST-2 (tetherin, CD317, and HM1.24) is induced by interferon and restricts virus release by tethering the enveloped viruses to the cell surface. The effect of…”
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MxB inhibits long interspersed element type 1 retrotransposition
Published in PLoS genetics (16-02-2022)“…Long interspersed element type 1 (LINE-1, also L1 for short) is the only autonomously transposable element in the human genome. Its insertion into a new…”
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Immunogenicity of a vaccinia virus-based severe acute respiratory syndrome coronavirus 2 vaccine candidate
Published in Frontiers in immunology (22-07-2022)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines provide essential tools for the control of the COVID-19 pandemic. A number of…”
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Rapid and sensitive one-tube detection of mpox virus using RPA-coupled CRISPR-Cas12 assay
Published in Cell reports methods (23-10-2023)“…Mpox is caused by a zoonotic virus belonging to the Orthopoxvirus genus and the Poxviridae family. In this study, we develop a recombinase polymerase…”
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Vaccinia virus viability under different environmental conditions and different disinfectants treatment
Published in Biosafety and health (01-02-2024)“…•Significance of the study Our study emphasizes the prolonged viability of poxviruses in the environment and presents a simple yet effective approach to…”
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Tetherin inhibits prototypic foamy virus release
Published in Virology journal (02-05-2011)“…Tetherin (also known as BST-2, CD317, and HM1.24) is an interferon- induced protein that blocks the release of a variety of enveloped viruses, such as…”
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IFP35 Is Involved in the Antiviral Function of Interferon by Association with the Viral Tas Transactivator of Bovine Foamy Virus
Published in Journal of Virology (01-05-2008)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A cloud-resolving modeling study of a torrential rainfall event over China
Published in Journal of Geophysical Research - Atmospheres (16-09-2007)“…A torrential rainfall event that occurred in Hunan, China in June 2004 is investigated using a two‐dimensional cloud‐resolving simulation. The model is…”
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Torrential rainfall responses to radiation and ice clouds over Jiang-Huai Valley, China in July 2007
Published in Asia-Pacific journal of atmospheric sciences (01-08-2013)“…The effects of radiation and ice clouds on a torrential rainfall event of Jiang-Huai Valley over China are investigated through a series of two-dimensional…”
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Dimerization of BTas is required for the transactivational activity of bovine foamy virus
Published in Virology (New York, N.Y.) (20-06-2008)“…Abstract The BTas protein of bovine foamy virus (BFV) is a 249-amino-acid nuclear regulatory protein which transactivates viral gene expression directed by the…”
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SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response
Published in Science signaling (12-04-2022)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the unprecedented coronavirus disease 2019 (COVID-19) pandemic. Critical cases of COVID-19…”
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PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing
Published in Science signaling (26-11-2019)“…Cyclic GMP-AMP synthase (cGAS) is a major sensor of cytosolic DNA from invading pathogens and damaged cellular organelles. Activation of cGAS promotes…”
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