Search Results - "Xu, Dengqiu"

AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1 by Xiao, Liwei, Liu, Jing, Sun, Zongchao, Yin, Yujing, Mao, Yan, Xu, Dengqiu, Liu, Lin, Xu, Zhisheng, Guo, Qiqi, Ding, Chenyun, Sun, Wanping, Yang, Likun, Zhou, Zheng, Zhou, Danxia, Fu, Tingting, Zhou, Wenjing, Zhu, Yuangang, Chen, Xiao-Wei, Li, John Zhong, Chen, Shuai, Xie, Xiaoduo, Gan, Zhenji

“…Mitochondria are essential for maintaining skeletal muscle metabolic homeostasis during adaptive response to a myriad of physiologic or pathophysiological…”
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FNIP1 abrogation promotes functional revascularization of ischemic skeletal muscle by driving macrophage recruitment by Sun, Zongchao, Yang, Likun, Kiram, Abdukahar, Yang, Jing, Yang, Zhuangzhuang, Xiao, Liwei, Yin, Yujing, Liu, Jing, Mao, Yan, Zhou, Danxia, Yu, Hao, Zhou, Zheng, Xu, Dengqiu, Jia, Yuhuan, Ding, Chenyun, Guo, Qiqi, Wang, Hongwei, Li, Yan, Wang, Li, Fu, Tingting, Hu, Shijun, Gan, Zhenji

“…Ischaemia of the heart and limbs attributable to compromised blood supply is a major cause of mortality and morbidity. The mechanisms of functional…”
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Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability by Zhou, Wang, Chen, Xi, Zhao, Guolin, Xu, Dengqiu, Jiang, Zhenzhou, Zhang, Luyong, Wang, Tao

“…Psoralen is a major component of the common traditional Chinese medicine (FP). In this study, we focused on psoralen to explore FP-induced hepatotoxicity and…”
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Possible role of hepatic macrophage recruitment and activation in triptolide-induced hepatotoxicity by Wang, Lu, Xu, Dengqiu, Li, Liping, Xing, Xin, Liu, Li, Ismail Abdelmotalab, Mohammed, Xiao, Li, Pang, Tao, Huang, Xin, Wang, Xinzhi, Wang, Tao, Jiang, Zhenzhou, Zhang, Luyong, Sun, Lixin

“…Hepatic macrophages are central players in the pathogenesis of some liver diseases, but few studies have examined the effect of triptolide (TP) on these cells…”
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A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1 by Xu, Dengqiu, Zhao, Lei, Jiang, Jingwei, Li, Sijia, Sun, Zeren, Huang, Xiaofei, Li, Chunjie, Wang, Tao, Sun, Lixin, Li, Xihua, Jiang, Zhenzhou, Zhang, Luyong

“…Background Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by the loss of dystrophin, which results in inflammation, fibrosis, and the…”
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TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy by Xu, Dengqiu, Li, Sijia, Wang, Lu, Jiang, Jingwei, Zhao, Lei, Huang, Xiaofei, Sun, Zeren, Li, Chunjie, Sun, Lixin, Li, Xihua, Jiang, Zhenzhou, Zhang, Luyong

“…Background Transforming growth factor‐β‐activated kinase 1 (TAK1) plays a key role in regulating fibroblast and myoblast proliferation and differentiation…”
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Drp1-associated mitochondrial dysfunction and mitochondrial autophagy: a novel mechanism in triptolide-induced hepatotoxicity by Hasnat, Muhammad, Yuan, Ziqiao, Naveed, Muhammad, Khan, Asifullah, Raza, Faisal, Xu, Dengqiu, Ullah, Aftab, Sun, Linxin, Zhang, Luyong, Jiang, Zhenzhou

“…Triptolide being an active ingredient of Chinese herbal plant Tripterygium wilfordii Hook f. has severe hepatotoxicity. Previous studies from our lab reported…”
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Comments on ‘FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics’ by Yin, Yujing, Xu, Dengqiu, Mao, Yan, Gan, Zhenji

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FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics by Yin, Yujing, Xu, Dengqiu, Mao, Yan, Xiao, Liwei, Sun, Zongchao, Liu, Jing, Zhou, Danxia, Xu, Zhisheng, Liu, Lin, Fu, Tingting, Ding, Chenyun, Guo, Qiqi, Sun, Wanping, Zhou, Zheng, Yang, Likun, Jia, Yuhuan, Chen, Xinyi, Gan, Zhenji

“…Metabolically beneficial beige adipocytes offer tremendous potential to combat metabolic diseases. The folliculin interacting protein 1 (FNIP1) is implicated…”
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A new therapeutic effect of fenofibrate in Duchenne muscular dystrophy: The promotion of myostatin degradation by Sun, Zeren, Xu, Dengqiu, Zhao, Lei, Li, Xihua, Li, Sijia, Huang, Xiaofei, Li, Chunjie, Sun, Lixin, Liu, Bing, Jiang, Zhenzhou, Zhang, Luyong

“…Background and Purpose Duchenne muscular dystrophy (DMD) is a degenerative muscle disease with no effective drug treatment. This study investigated the…”
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IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay by He, Shengqi, Fu, Tingting, Yu, Yue, Liang, Qinhao, Li, Luyao, Liu, Jing, Zhang, Xuan, Zhou, Qian, Guo, Qiqi, Xu, Dengqiu, Chen, Yong, Wang, Xiaolong, Chen, Yulin, Liu, Jianmiao, Gan, Zhenji, Liu, Yong

“…Skeletal muscle can undergo a regenerative process from injury or disease to preserve muscle mass and function, which is critically influenced by cellular…”
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A new hypoglycemic mechanism of catalpol revealed by enhancing MyoD/MyoG-mediated myogenesis by Xu, Dengqiu, Wang, Lu, Jiang, Zhenzhou, Zhao, Guolin, Hassan, Hozeifa M., Sun, Lixin, Fan, Sisi, Zhou, Zhixing, Zhang, Luyong, Wang, Tao

“…Enhancing myogenesis has been identified as a possible target to improve insulin sensitivity and protect against metabolic diseases. Catalpol, an iridoid…”
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TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma by Geng, Longpo, Zhu, Mingming, Luo, Dongjun, Chen, Huihui, Li, Binghua, Lao, Yuanxiang, An, Hongda, Wu, Yue, Li, Yunzheng, Xia, Anliang, Shi, Yi, Tong, Zhuting, Lu, Shanshan, Xu, Dengqiu, Wang, Xu, Zhang, Wenjun, Sun, Beicheng, Xu, Zhu

“…Hepatocellular carcinoma (HCC) stands as the fifth most prevalent malignant tumor on a global scale and presents as the second leading cause of cancer-related…”
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Mitochondrial dysfunction and inhibition of myoblast differentiation in mice with high‐fat‐diet‐induced pre‐diabetes by Xu, Dengqiu, Jiang, Zhenzhou, Sun, Zeren, Wang, Lu, Zhao, Guolin, Hassan, Hozeifa M., Fan, Sisi, Zhou, Wang, Han, Shuangshuang, Zhang, Luyong, Wang, Tao

“…Pre‐diabetes is characterized by impaired glucose tolerance (IGT) and/or impaired fasting glucose. Impairment of skeletal muscle function is closely associated…”
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Key role of organic cation transporter 2 for the nephrotoxicity effect of triptolide in rheumatoid arthritis by Shen, Qingqing, Wang, Jingjing, Yuan, Ziqiao, Jiang, Zhenzhou, Shu, Ting, Xu, Dengqiu, He, Jinyong, Zhang, Luyong, Huang, Xin

“…•Inflammation state aggravated the nephrotoxicity of TP in CIA rats and in cells.•Renal uptake of TP mainly depends on OCT2 in rat kidney slices and HEK-293T…”
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Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouse by Mao, Yan, Jin, Zhen, Yang, Jing, Xu, Dengqiu, Zhao, Lei, Kiram, Abdukahar, Yin, Yujing, Zhou, Danxia, Sun, Zongchao, Xiao, Liwei, Zhou, Zheng, Yang, Likun, Fu, Tingting, Xu, Zhisheng, Jia, Yuhuan, Chen, Xinyi, Niu, Feng-Nan, Li, Xihua, Zhu, Zezhang, Gan, Zhenji

“…Clinical evidence indicates a close association between muscle dysfunction and bone loss; however, the underlying mechanisms remain unclear. Here, we report…”
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Mitochondria-dependent apoptosis in triptolide-induced hepatotoxicity is associated with the Drp1 activation by Hasnat, Muhammad, Yuan, Ziqiao, Ullah, Aftab, Naveed, Muhammad, Raza, Faisal, Baig, Mirza Muhammad Faran Ashraf, Khan, Asifullah, Xu, Dengqiu, Su, Yuwen, Sun, Linxin, Zhang, Luyong, Jiang, Zhenzhou

“…How triptolide is associated with mitochondrial dysfunction and apoptosis in connection with its hepatotoxicity remains unclear. The objective of our study was…”
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Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action by Elhafiz, Muhanad, Zhao, Guolin, Ismail, Mohammed, Xu, Dengqiu, Das, Debanjan, Fan, Sisi, Cheng, Nong, Yousef, Bashir A., Jiang, Zhenzhou, Zhang, Luyong

“…The exact role of VD deficiency in the development of non-alcoholic fatty liver disease (NAFLD) remains unknown. In this study, we induced VD deficiency by…”
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8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity by Zhao, Guolin, Xu, Dengqiu, Yuan, Ziqiao, Jiang, Zhenzhou, Zhou, Wang, Li, Zhijian, Yin, Mengyue, Zhou, Zhixing, Zhang, Luyong, Wang, Tao

“…Graphical abstract…”
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Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis by Yang, Tingting, Mei, Huifang, Xu, Dengqiu, Zhou, Wang, Zhu, Xiaoyu, Sun, Lixin, Huang, Xin, Wang, Xue, Shu, Ting, Liu, Jia, Ding, Jiaxin, Hassan, H.M., Zhang, Luyong, Jiang, Zhenzhou

“…Hepatocyte polarization is essential for biliary secretion, and loss of polarity causes bile secretory failure and hepatotoxicity. Here, we showed that…”
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