Search Results - "Xu, Congfeng"

Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation by Wang, Lingyu, Gong, Zizhen, Zhang, Xiuyuan, Zhu, Fangxinxing, Liu, Yuchen, Jin, Chaozhi, Du, Xixi, Xu, Congfeng, Chen, Yingwei, Cai, Wei, Tian, Chunyan, Wu, Jin

“…High-fat diet (HFD) leads to systemic low-grade inflammation, which has been involved in the pathogenesis of diverse metabolic and inflammatory diseases. Colon…”
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Curcumin suppresses NLRP3 inflammasome activation and protects against LPS‐induced septic shock by Gong, Zizhen, Zhou, Jiefei, Li, Hui, Gao, Yanhong, Xu, Congfeng, Zhao, Shengnan, Chen, Yingwei, Cai, Wei, Wu, Jin

“…SCOPE: The NLRP3 inflammasome responds to various pathogen‐derived factors and danger‐associated molecules, mediating IL‐1β maturation, therefore is involved…”
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Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis by Gong, Zizhen, Zhou, Jiefei, Zhao, Shengnan, Tian, Chunyan, Wang, Panliang, Xu, Congfeng, Chen, Yingwei, Cai, Wei, Wu, Jin

“…Accumulation of hydrophobic bile acids in the liver contributes to cholestatic liver injury. Inflammation induced by excessive bile acids is believed to play a…”
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Sacubitril/valsartan inhibits the proliferation of vascular smooth muscle cells through notch signaling and ERK1/2 pathway by Xu, Congfeng, Zhang, Ning, Yuan, Hong, Wang, Liren, Li, Yonghong

“…To explore the role and mechanism of Notch signaling and ERK1/2 pathway in the inhibitory effect of sacubitril/valsartan on the proliferation of vascular…”
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Establishing practical strategies to run high loading corn stover anaerobic digestion: Methane production performance and microbial responses by Wang, Haipeng, Li, Jiawei, Zhao, Yiquan, Xu, Congfeng, Zhang, Keqiang, Li, Jiajia, Yan, Lei, Gu, Ji-Dong, Wei, Dan, Wang, Weidong

“…•TS was increased gradually until CS AD system was acidized.•Methane production rate was the highest in 13% TS, 15% TS led to acidification.•Adding 30% CM…”
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Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination by Xu, Congfeng, Feng, Kuan, Zhao, Xiaonan, Huang, Shiqian, Cheng, Yiji, Qian, Liu, Wang, Yanan, Sun, Hongxing, Jin, Min, Chuang, Tsung-Hsien, Zhang, Yanyun

“…Autophagy is an evolutionarily conserved biological process involved in an array of physiological and pathological events. Without proper control, autophagy…”
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Deoxycholic Acid Triggers NLRP3 Inflammasome Activation and Aggravates DSS-Induced Colitis in Mice by Zhao, Shengnan, Gong, Zizhen, Zhou, Jiefei, Tian, Chunyan, Gao, Yanhong, Xu, Congfeng, Chen, Yingwei, Cai, Wei, Wu, Jin

“…A westernized high-fat diet (HFD) is associated with the development of inflammatory bowel disease (IBD). High-level fecal deoxycholic acid (DCA) caused by HFD…”
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Photoactivated adenylyl cyclases attenuate sepsis-induced cardiomyopathy by suppressing macrophage-mediated inflammation by Xia, Guofang, Shi, Hongyu, Su, Yuanyuan, Han, Beibei, Shen, Chengxing, Gao, Shiqiang, Chen, Zhong, Xu, Congfeng

“…Sepsis-induced myocardiopathy, characterized by innate immune cells infiltration and proinflammatory cytokines release, may lead to perfusion failure or even…”
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Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll‐like receptor‐mediated autophagy by Xu, Congfeng, Liu, Jin, Hsu, Li‐Chung, Luo, Yunping, Xiang, Rong, Chuang, Tsung‐Hsien

“…ABSTRACT Autophagy is one of the downstream effector mechanisms for elimination of intracellular microbes following activation of the Toll‐like receptors…”
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Modulation of cardiac resident macrophages immunometabolism upon high-fat-diet feeding in mice by Zhu, Simeng, Liu, Yujia, Xia, Guofang, Wang, Xiaoqing, Du, Ailian, Wu, Jin, Wang, Yanpeng, Wang, Yuanlong, Shen, Chengxing, Wei, Peng, Xu, Congfeng

“…A high-fat diet (HFD) contributes to various metabolic disorders and obesity, which are major contributors to cardiovascular disease. As an essential regulator…”
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Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation by Li, Dan, Zhou, Jiefei, Wang, Lingyu, Gong, Zizhen, Le, Huijuan, Huang, Ye, Xu, Congfeng, Tian, Chunyan, Cai, Wei, Wu, Jin

“…Abstract Background High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial…”
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Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release by Wu, Jin, Cai, Wei, Xu, Congfeng, Zhou, Jiefei, Wang, Lingyu, Tian, Chunyan, Du, Xixi, Gong, Zizhen, Zhao, Shengnan, Chen, Yingwei

“…We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3…”
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T cell immunoglobulin and mucin domain-containing protein 3 is highly expressed in patients with acute decompensated heart failure and predicts mid-term prognosis by Meng, Xin, Xia, Guofang, Zhang, Lili, Xu, Congfeng, Chen, Zhong

“…Background and aims T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is mainly expressed by immune cells and plays an immunomodulatory role…”
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Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesis of myasthenia gravis by Du, Ailian, Huang, Shiqian, Zhao, Xiaonan, Feng, Kuan, Zhang, Shuangyan, Huang, Jiefang, Miao, Xiang, Baggi, Fulvio, Ostrom, Rennolds S., Zhang, Yanyun, Chen, Xiangjun, Xu, Congfeng

“…Myasthenia gravis is an autoimmune disorder of the neuromuscular junction manifested as fatigable muscle weakness, which is typically caused by pathogenic…”
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A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition by Liu, Jin, Xu, Congfeng, Hsu, Li-Chung, Luo, Yunping, Xiang, Rong, Chuang, Tsung-Hsien

“…Toll-like receptors play important roles in regulating immunity against microbial infections. Toll-like receptor 8 (TLR8) belongs to a subfamily comprising…”
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Hepatitis B virus dampens autophagy maturation via negative regulation of Rab7 expression by Zhou, Tianhui, Jin, Min, Ding, Yongsen, Zhang, Yi, Sun, Ye, Huang, Shiqian, Xie, Qing, Xu, Congfeng, Cai, Wei

“…Hepatitis B virus (HBV) infection brings a huge challenge for medical health practitioners. It has been reported that invaded HBV escapes autophagic…”
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Adenylyl cyclase 6 activation negatively regulates TLR4 signaling through lipid raft-mediated endocytosis by Cai, Wei, Du, Ailian, Feng, Kuan, Zhao, Xiaonan, Qian, Liu, Ostrom, Rennolds S, Xu, Congfeng

“…Proper intracellular localization of TLRs is essential for their signaling and biological function. Endocytosis constitutes a key step in protein turnover, as…”
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Long-Term Mesophilic Anaerobic Co-Digestion of Swine Manure with Corn Stover and Microbial Community Analysis by Wang, Haipeng, Lim, Teng Teeh, Duong, Cuong, Zhang, Wei, Xu, Congfeng, Yan, Lei, Mei, Zili, Wang, Weidong

“…Long-term anaerobic co-digestion of swine manure (SM) and corn stover (CS) was conducted using semi-continuously loaded digesters under mesophilic conditions…”
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TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7 by Lai, Chao-Yang, Liu, Yi-Ling, Yu, Guann-Yi, Maa, Ming-Chei, Leu, Tzeng-Horng, Xu, Congfeng, Luo, Yunping, Xiang, Rong, Chuang, Tsung-Hsien

“…Highlights • TLR7/8 agonists are being investigated for using as anti-microbial agents and vaccine adjuvant for humans and domestic animals. • Rabbit TLR8 is…”
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Activation of rabbit TLR9 by different CpG-ODN optimized for mouse and human TLR9 by Liu, Jin, Xu, Congfeng, Liu, Yi-Ling, Matsuo, Hanako, Hsieh, Rebecca Pe-feng, Lo, Jeng-Fan, Tseng, Ping-Hui, Yuan, Chiun-Jye, Luo, Yunping, Xiang, Rong, Chuang, Tsung-Hsien

“…Abstract Synthetic CpG-oligodeoxynucleotides (CpG-ODN) are potent adjuvants that accelerate and boost antigen-specific immune responses. Toll-like receptor 9…”
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