Search Results - "Xu, Anlong"

HaploMerger2: rebuilding both haploid sub-assemblies from high-heterozygosity diploid genome assembly by Huang, Shengfeng, Kang, Mingjing, Xu, Anlong

“…De novo assembly is a difficult issue for heterozygous diploid genomes. The advent of high-throughput short-read and long-read sequencing technologies provides…”
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Generation of hepatobiliary organoids from human induced pluripotent stem cells by Wu, Fenfang, Wu, Di, Ren, Yong, Huang, Yuhua, Feng, Bo, Zhao, Nan, Zhang, Taotao, Chen, Xiaoni, Chen, Shangwu, Xu, Anlong

“…[Display omitted] •We established a system to generate hiPSC-derived hepatobiliary organoids in vitro.•To varying degrees, this model recapitulated several key…”
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Traditional medicine is the valuable resource for global health by Anlong Xu

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beta-Carboline alkaloids: biochemical and pharmacological functions by Cao, Rihui, Peng, Wenlie, Wang, Zihou, Xu, Anlong

“…beta-Carboline alkaloids are a large group of natural and synthetic indole alkaloids with different degrees of aromaticity, some of which are widely…”
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Immune states: integrated views of immunity by combining traditional Chinese medicine and modern medicine by Xu, Anlong, Zhi, Yuxing

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Characterization of GSDME in amphioxus provides insights into the functional evolution of GSDM-mediated pyroptosis by Wang, Xinli, Wei, Xuxia, Lu, Yan, Wang, Qinghuan, Fu, Rong, Wang, Yin, Wang, Qin, Wang, Xiangyan, Chen, Shangwu, Xu, Anlong, Yuan, Shaochun

“…Members of the gasdermin (GSDM) family are pore-forming effectors that cause membrane permeabilization and pyroptosis, a lytic proinflammatory type of cell…”
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Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing by Fu, Yonggui, Sun, Yu, Li, Yuxin, Li, Jie, Rao, Xingqiang, Chen, Chong, Xu, Anlong

“…Tandem 3' UTRs produced by alternative polyadenylation (APA) play an important role in gene expression by impacting mRNA stability, translation, and…”
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Application and Mechanisms of Triptolide in the Treatment of Inflammatory Diseases-A Review by Yuan, Kai, Li, Xiaohong, Lu, Qingyi, Zhu, Qingqing, Jiang, Haixu, Wang, Ting, Huang, Guangrui, Xu, Anlong

“…Bioactive compounds from medicinal plants with anti-inflammatory and immunosuppressive effects have been emerging as important sources of drugs for the…”
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Intravenous transplantation of bone marrow-derived mesenchymal stem cells improved behavioral deficits and altered fecal microbiota composition of BTBR mice by Jingyi, Li, Lin, Wang, Yuan, Chen, Lingling, Zhang, Qianqian, Jiang, Anlong, Xu, Yansong, Gao

“…It is recognized that autism spectrum disorder (ASD) is a highly complex neurodevelopmental disorder with communication deficits as well as multiple social…”
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Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis-NETosis Balance of Neutrophils by Li, Xiaohong, Yuan, Kai, Zhu, Qingqing, Lu, Qingyi, Jiang, Haixu, Zhu, Mengmeng, Huang, Guangrui, Xu, Anlong

“…Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by symmetric polyarthritis with swelling and pain at synovial joints. In RA patients,…”
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Cell Cycle Regulation by Alternative Polyadenylation of CCND1 by Wang, Qiong, He, Guopei, Hou, Mengmeng, Chen, Liutao, Chen, Shangwu, Xu, Anlong, Fu, Yonggui

“…Global shortening of 3′UTRs by alternative polyadenylation (APA) has been observed in cancer cells. However, the role of APA in cancer remains unknown. CCND1…”
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Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination by Huang, Shengfeng, Tao, Xin, Yuan, Shaochun, Zhang, Yuhang, Li, Peiyi, Beilinson, Helen A., Zhang, Ya, Yu, Wenjuan, Pontarotti, Pierre, Escriva, Hector, Le Petillon, Yann, Liu, Xiaolong, Chen, Shangwu, Schatz, David G., Xu, Anlong

“…Co-option of RAG1 and RAG2 for antigen receptor gene assembly by V(D)J recombination was a crucial event in the evolution of jawed vertebrate adaptive…”
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Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis by Huang, Guangrui, Yuan, Kai, Zhu, Qingqing, Zhang, Shan, Lu, Qingyi, Zhu, Mengmeng, Sheng, Honghao, Yu, Ruipeng, Luo, Guangbin, Xu, Anlong

“…•TP alleviated AA by reducing neutrophil recruitment.•TP suppressing the expression of IL-6 and TNF-α in peripheral blood of AA mice.•TP suppressed the…”
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The role of alternative polyadenylation in the antiviral innate immune response by Jia, Xin, Yuan, Shaochun, Wang, Yao, Fu, Yonggui, Ge, Yong, Ge, Yutong, Lan, Xihong, Feng, Yuchao, Qiu, Feifei, Li, Peiyi, Chen, Shangwu, Xu, Anlong

“…Alternative polyadenylation (APA) is an important regulatory mechanism of gene functions in many biological processes. However, the extent of 3′ UTR variation…”
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Subchronic Toxicity Studies of Cortex Dictamni Extracts in Mice and Its Potential Hepatotoxicity Mechanisms in Vitro by Fan, Qiongyin, Zhao, Baosheng, Wang, Chunguo, Zhang, Jingxuan, Wu, Jinying, Wang, Ting, Xu, Anlong

“…Cortex Dictamni is a commonly-used traditional Chinese herbal medicine for the treatment of skin inflammation, tinea, and eczema. Recently, some studies…”
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A simple protocol to establish a conditionally immortalized mouse podocyte cell line by Huang, Yujiao, Geng, Jie, Wang, Mengdan, Liu, Wenbin, Hu, Haikun, Shi, Wei, Li, Mei, Huo, Guiyang, Huang, Guangrui, Xu, Anlong

“…Podocytes are specialized terminally differentiated cells in the glomerulus that are the primary target cells in many glomerular diseases. However, the current…”
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Functional regulation of an ancestral RAG transposon ProtoRAG by a trans-acting factor YY1 in lancelet by Liu, Song, Yuan, Shaochun, Gao, Xiaoman, Tao, Xin, Yu, Wenjuan, Li, Xu, Chen, Shangwu, Xu, Anlong

“…The discovery of ancestral RAG transposons in early deuterostomia reveals the origin of vertebrate V(D)J recombination. Here, we analyze the functional…”
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Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses by Ge, Yong, Huang, Jingrong, Chen, Rong, Fu, Yonggui, Ling, Tao, Ou, Xin, Rong, Xiaohui, Cheng, Youxiang, Lin, Yi, Zhou, Fengyi, Lu, Chuanjian, Yuan, Shaochun, Xu, Anlong

“…Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates mRNA isoforms with alternative 3' untranslated regions (3' UTRs)…”
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The gut microbiota intervenes in glucose tolerance and inflammation by regulating the biosynthesis of taurodeoxycholic acid and carnosine by Zhen, Jianhua, Zhang, Yunan, Li, Yini, Zhou, Yali, Cai, Yanan, Huang, Guangrui, Xu, Anlong

“…This study aims to investigate the pathogenesis of hyperglycemia and its associated vasculopathy using multiomics analyses in diabetes and impaired glucose…”
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HaploMerger: reconstructing allelic relationships for polymorphic diploid genome assemblies by Huang, Shengfeng, Chen, Zelin, Huang, Guangrui, Yu, Ting, Yang, Ping, Li, Jie, Fu, Yonggui, Yuan, Shaochun, Chen, Shangwu, Xu, Anlong

“…Whole-genome shotgun assembly has been a long-standing issue for highly polymorphic genomes, and the advent of next-generation sequencing technologies has made…”
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