Search Results - "Xu, Alexander"

Nanoneedle Platforms: The Many Ways to Pierce the Cell Membrane by He, Gen, Hu, Ning, Xu, Alexander M., Li, Xiangling, Zhao, Yunlong, Xie, Xi

“…Establishing techniques to efficiently and nondestructively access the intracellular milieu is essential for many biomedical and scientific applications,…”
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Nanostraws for Direct Fluidic Intracellular Access by VanDersarl, Jules J, Xu, Alexander M, Melosh, Nicholas A

“…Nanomaterials are promising candidates to improve the delivery efficiency and control of active agents such as DNA or drugs directly into cells. Here we…”
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Nanostraw–Electroporation System for Highly Efficient Intracellular Delivery and Transfection by Xie, Xi, Xu, Alexander M, Leal-Ortiz, Sergio, Cao, Yuhong, Garner, Craig C, Melosh, Nicholas A

“…Nondestructive introduction of genes, proteins, and small molecules into mammalian cells with high efficiency is a challenging, yet critical, process. Here we…”
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Mechanical Model of Vertical Nanowire Cell Penetration by Xie, Xi, Xu, Alexander M, Angle, Matthew R, Tayebi, Noureddine, Verma, Piyush, Melosh, Nicholas A

“…Direct access into cells’ interiors is essential for biomolecular delivery, gene transfection, and electrical recordings yet is challenging due to the cell…”
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Receptor Tyrosine Kinase Coactivation Networks in Cancer by XU, Alexander M, HUANG, Paul H

“…Cancer cells employ multiple mechanisms to evade tightly regulated cellular processes such as proliferation, apoptosis, and senescence. Systems-wide analyses…”
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Oncogenic EGFR signaling networks in glioma by Huang, Paul H, Xu, Alexander M, White, Forest M

“…The epidermal growth factor receptor (EGFR) is a primary contributor to glioblastoma (GBM) initiation and progression. Here, we examine how EGFR and key…”
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Quantification of nanowire penetration into living cells by Xu, Alexander M., Aalipour, Amin, Leal-Ortiz, Sergio, Mekhdjian, Armen H., Xie, Xi, Dunn, Alexander R., Garner, Craig C., Melosh, Nicholas A.

“…High-aspect ratio nanostructures such as nanowires and nanotubes are a powerful new tool for accessing the cell interior for delivery and sensing. Controlling…”
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Patients with prediabetes are at greater risk of developing diabetes 5 months postacute SARS-CoV-2 infection: a retrospective cohort study by Xu, Alexander Y., Wang, Stephen H., Duong, Tim Q.

“…IntroductionPatients with prediabetes who contract SARS-CoV-2 infection (COVID-19) could be at higher risk of developing frank diabetes compared those who do…”
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Fabrication of Sealed Nanostraw Microdevices for Oral Drug Delivery by Fox, Cade B, Cao, Yuhong, Nemeth, Cameron L, Chirra, Hariharasudhan D, Chevalier, Rachel W, Xu, Alexander M, Melosh, Nicholas A, Desai, Tejal A

“…The oral route is preferred for systemic drug administration and provides direct access to diseased tissue of the gastrointestinal (GI) tract. However, many…”
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Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood by Peng, Songming, Zaretsky, Jesse M., Ng, Alphonsus H.C., Chour, William, Bethune, Michael T., Choi, Jongchan, Hsu, Alice, Holman, Elizabeth, Ding, Xiaozhe, Guo, Katherine, Kim, Jungwoo, Xu, Alexander M., Heath, John E., Noh, Won Jun, Zhou, Jing, Su, Yapeng, Lu, Yue, McLaughlin, Jami, Cheng, Donghui, Witte, Owen N., Baltimore, David, Ribas, Antoni, Heath, James R.

“…Neoantigen-specific T cells are increasingly viewed as important immunotherapy effectors, but physically isolating these rare cell populations is challenging…”
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Shape Matters: Intravital Microscopy Reveals Surprising Geometrical Dependence for Nanoparticles in Tumor Models of Extravasation by Smith, Bryan Ronain, Kempen, Paul, Bouley, Donna, Xu, Alexander, Liu, Zhuang, Melosh, Nicholas, Dai, Hongjie, Sinclair, Robert, Gambhir, Sanjiv Sam

“…Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles…”
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Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line by Su, Yapeng, Ko, Melissa E., Cheng, Hanjun, Zhu, Ronghui, Xue, Min, Wang, Jessica, Lee, Jihoon W., Frankiw, Luke, Xu, Alexander, Wong, Stephanie, Robert, Lidia, Takata, Kaitlyn, Yuan, Dan, Lu, Yue, Huang, Sui, Ribas, Antoni, Levine, Raphael, Nolan, Garry P., Wei, Wei, Plevritis, Sylvia K., Li, Guideng, Baltimore, David, Heath, James R.

“…The determination of individual cell trajectories through a high-dimensional cell-state space is an outstanding challenge for understanding biological changes…”
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HIV and prior exposure to antiretroviral therapy alter tumour composition and tumour: T‐cell associations in diffuse large B‐cell lymphoma by Coelho, Jenny, Roush, Sophia M., Xu, Alexander M., Puranam, Kaushik, Mponda, Marriam, Kasonkanji, Edwards, Mulenga, Maurice, Tomoka, Tamiwe, Galeotti, Jonathan, Brownlee, Amy, Ghadially, Hormas, Damania, Blossom, Painschab, Matthew, Merchant, Akil, Gopal, Satish, Fedoriw, Yuri

“…Summary Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of lymphoma worldwide, accounting for up to 40% of new non‐Hodgkin Lymphoma (NHL)…”
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Direct Intracellular Delivery of Cell‐Impermeable Probes of Protein Glycosylation by Using Nanostraws by Xu, Alexander M., Wang, Derek S., Shieh, Peyton, Cao, Yuhong, Melosh, Nicholas A.

“…Bioorthogonal chemistry is an effective tool for elucidating metabolic pathways and measuring cellular activity, yet its use is currently limited by the…”
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Epidemiology of Traumatic Esophageal Injury: An Analysis of the National Trauma Data Bank by Xu, Alexander A, Breeze, Janis L, Paulus, Jessica K, Bugaev, Nikolay

“…Existing literature on traumatic injury of the esophagus (TIE) is limited. We aimed to describe the clinical characteristics and outcomes of TIE. We reviewed…”
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Plasma Membrane and Actin Cytoskeleton as Synergistic Barriers to Nanowire Cell Penetration by Aalipour, Amin, Xu, Alexander M, Leal-Ortiz, Sergio, Garner, Craig C, Melosh, Nicholas A

“…Nanowires are a rapidly emerging platform for manipulation of and material delivery directly into the cell cytosol. These high aspect ratio structures can…”
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A Paratope-Enhanced Method to Determine Breadth and Depth TCR Clonal Metrics of the Private Human T-Cell Vaccine Response after SARS-CoV-2 Vaccination by Li, Dalin, Pavlovitch-Bedzyk, Ana Jimena, Ebinger, Joseph E, Khan, Abdul, Hamideh, Mohamed, Merchant, Akil, Figueiredo, Jane C, Cheng, Susan, Davis, Mark M, McGovern, Dermot P B, Melmed, Gil Y, Xu, Alexander M, Braun, Jonathan

“…Quantitative metrics for vaccine-induced T-cell responses are an important need for developing correlates of protection and their use in vaccine-based medical…”
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Rapid spatial and temporal controlled signal delivery over large cell culture areas by VanDersarl, Jules J, Xu, Alexander M, Melosh, Nicholas A

“…Controlled chemical delivery in microfluidic cell culture devices often relies on slowly evolving diffusive gradients, as the spatial and temporal control…”
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Integrated measurement of intracellular proteins and transcripts in single cells by Xu, Alexander M, Liu, Qianhe, Takata, Kaitlyn L, Jeoung, Sarah, Su, Yapeng, Antoshechkin, Igor, Chen, Sisi, Thomson, Matthew, Heath, James R

“…Biological function arises from the interplay of proteins, transcripts, and metabolites. An ongoing revolution in miniaturization technologies has created…”
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Rapid, Selective, and Ultra-Sensitive Field Effect Transistor-Based Detection of Escherichia coli by Zaidan, Liena, Novodchuk, Inna, H Xu, Alexander, Nica, Alexandru, Takaloo, Saeed, Lloyd, Christopher, Karimi, Reza, Sanderson, Joe, Bajcsy, Michal, Yavuz, Mustafa

“…( ) was among the first organisms to have its complete genome published (Genome Sequence of 1997 Science). It is used as a model system in microbiology…”
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