Search Results - "Xu, Adele F."

The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity by Simsek, Deniz, Tiu, Gerald C., Flynn, Ryan A., Byeon, Gun W., Leppek, Kathrin, Xu, Adele F., Chang, Howard Y., Barna, Maria

“…During eukaryotic evolution, ribosomes have considerably increased in size, forming a surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may…”
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Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics by Leppek, Kathrin, Byeon, Gun Woo, Kladwang, Wipapat, Wayment-Steele, Hannah K., Kerr, Craig H., Xu, Adele F., Kim, Do Soon, Topkar, Ved V., Choe, Christian, Rothschild, Daphna, Tiu, Gerald C., Wellington-Oguri, Roger, Fujii, Kotaro, Sharma, Eesha, Watkins, Andrew M., Nicol, John J., Romano, Jonathan, Tunguz, Bojan, Diaz, Fernando, Cai, Hui, Guo, Pengbo, Wu, Jiewei, Meng, Fanyu, Shi, Shuai, Participants, Eterna, Dormitzer, Philip R., Solórzano, Alicia, Barna, Maria, Das, Rhiju

“…Therapeutic mRNAs and vaccines are being developed for a broad range of human diseases, including COVID-19. However, their optimization is hindered by mRNA…”
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A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production by Genuth, Naomi R., Shi, Zhen, Kunimoto, Koshi, Hung, Victoria, Xu, Adele F., Kerr, Craig H., Tiu, Gerald C., Oses-Prieto, Juan A., Salomon-Shulman, Rachel E. A., Axelrod, Jeffrey D., Burlingame, Alma L., Loh, Kyle M., Barna, Maria

“…Recent findings suggest that the ribosome itself modulates gene expression. However, whether ribosomes change composition across cell types or control cell…”
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Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss by Sturzu, Anthony C, Rajarajan, Kuppusamy, Passer, Derek, Plonowska, Karolina, Riley, Alyssa, Tan, Timothy C, Sharma, Arun, Xu, Adele F, Engels, Marc C, Feistritzer, Rebecca, Li, Guang, Selig, Martin K, Geissler, Richard, Robertson, Keston D, Scherrer-Crosbie, Marielle, Domian, Ibrahim J, Wu, Sean M

“…Heart development is tightly regulated by signaling events acting on a defined number of progenitor and differentiated cardiac cells. Although loss of function…”
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Guanidinium-Rich, Glycerol-Derived Oligocarbonates: A New Class of Cell-Penetrating Molecular Transporters That Complex, Deliver, and Release siRNA by Wender, Paul A, Huttner, Melanie A, Staveness, Daryl, Vargas, Jessica R, Xu, Adele F

“…A highly versatile and step-economical route to a new class of guanidinium-rich molecular transporters and evaluation of their ability to complex, deliver, and…”
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