Search Results - "Xiouras, Christos"

Attrition-Enhanced Deracemization of NaClO3: Comparison between Ultrasonic and Abrasive Grinding by Xiouras, Christos, Van Aeken, Jasper, Panis, Joris, Ter Horst, Joop H, Van Gerven, Tom, Stefanidis, Georgios D

“…Ultrasound-enhanced grinding is a more practical alternative to glass bead-enhanced grinding for performing attrition-enhanced deracemization at large scale or…”
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Particle Breakage Kinetics and Mechanisms in Attrition-Enhanced Deracemization by Xiouras, Christos, Fytopoulos, Antonios A, Ter Horst, Joop H, Boudouvis, Andreas G, Van Gerven, Tom, Stefanidis, Georgios D

“…In this study, we report on experiments designed to deconvolute the particle breakage kinetics and mechanism from the parallel phenomena (growth-dissolution,…”
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Towards Deracemization in the Absence of Grinding through Crystal Transformation, Ripening, and Racemization by Xiouras, Christos, Van Cleemput, Emma, Kumpen, Andries, Ter Horst, Joop H, Van Gerven, Tom, Stefanidis, Georgios D

“…New insights into the obscure mechanisms of solid-state deracemization phenomena are obtained by crystal ripening experiments that, contrary to standard…”
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Fundamentals and applications of microwave heating to chemicals separation processes by Li, Hong, Zhao, Zhenyu, Xiouras, Christos, Stefanidis, Georgios D., Li, Xingang, Gao, Xin

“…The aim of this review is to discuss the applications of microwave heating to separation and purification processes in chemical engineering from the…”
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Unraveling the Role of Fluid Shear on Primary Nucleation of Paracetamol through an Energy-Dissipation Rate Analysis by Devos, Cedric, Xiouras, Christos, Van Gerven, Tom, Kuhn, Simon

“…The effect of fluid shear on the primary nucleation of paracetamol in water, isopropyl alcohol, and acetonitrile was investigated. First, experiments were…”
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Enabling technologies for process intensification in pharmaceutical research and manufacturing by Xiouras, Christos, Kuijpers, Koen, Fanfair, Dayne, Dorbec, Matthieu, Gielen, Bjorn

“…A perspective is given on the status and outlook of enabling technologies for process intensification in pharmaceutical research and manufacturing. We focus on…”
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Precise particle size control during spherical agglomeration of benzoic acid by modification of the bridging liquid phase using TWEEN 20 by Merkelbach, Nele, Xiouras, Christos, Vancleef, Arne, Thomassen, Leen C.J., Braeken, Leen

“…The interest in spherical agglomeration processes in the pharmaceutical industry is rising due to the possibility of direct tableting of Active Pharmaceutical…”
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Applications of Artificial Intelligence and Machine Learning Algorithms to Crystallization by Xiouras, Christos, Cameli, Fabio, Quilló, Gustavo Lunardon, Kavousanakis, Mihail E., Vlachos, Dionisios G., Stefanidis, Georgios D.

“…Artificial intelligence and specifically machine learning applications are nowadays used in a variety of scientific applications and cutting-edge technologies,…”
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Intensification of solventless production of hydrophobically-modified ethoxylated urethanes (HEURs) by microwave heating by Tzortzi, Ioanna, Xiouras, Christos, Tserpes, Chrysovalantis, Tzani, Andromachi, Detsi, Anastasia, Van Gerven, Tom, Stefanidis, Georgios D.

“…•Microwave heating has been applied to the solvent-free HEUR synthesis.•Faster melting of PEG and faster rate of polymerization is possible with…”
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Crystal Growth Kinetics of an Industrial Active Pharmaceutical Ingredient: Implications of Different Representations of Supersaturation and Simultaneous Growth Mechanisms by Quilló, Gustavo Lunardon, Bhonsale, Satyajeet, Gielen, Bjorn, Van Impe, Jan F, Collas, Alain, Xiouras, Christos

“…The crystal growth kinetics of a proprietary active pharmaceutical ingredient (API) was investigated by isothermal seeded batch de-supersaturation experiments…”
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Furfural Synthesis from d-Xylose in the Presence of Sodium Chloride: Microwave versus Conventional Heating by Xiouras, Christos, Radacsi, Norbert, Sturm, Guido, Stefanidis, Georgios D.

“…We investigate the existence of specific/nonthermal microwave effects for the dehydration reaction of xylose to furfural in the presence of NaCl. Such effects…”
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Sonocrystallisation: Observations, theories and guidelines by Jordens, Jeroen, Gielen, Bjorn, Xiouras, Christos, Hussain, Mohammed Noorul, Stefanidis, Georgios D., Thomassen, Leen C.J., Braeken, Leen, Van Gerven, Tom

“…•Ultrasound has been applied in several crystallization processes.•The mechanism behind ultrasound-enhanced nucleation is not fully understood.•Low frequencies…”
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One-Step versus Two-Step Synthesis of Hydrophobically Modified Ethoxylated Urethanes: Benefits and Limitations by Tzortzi, Ioanna, Xiouras, Christos, Choustoulaki, Chrysi, Tzani, Andromachi, Detsi, Anastasia, Michaud, Guillaume, Van Gerven, Tom, Stefanidis, Georgios D.

“…Associative thickeners, such as hydrophobically modified ethoxylated urethanes (HEURs), are an important class of rheological modifiers allowing precise…”
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Crystal Growth, Dissolution, and Agglomeration Kinetics of Sodium Chlorate by Fytopoulos, Antonios A, Kavousanakis, Michail E, Van Gerven, Tom, Boudouvis, Andreas G, Stefanidis, Georgios D, Xiouras, Christos

“…The analysis, development, and implementation of novel complex industrial crystallization processes requires kinetic knowledge of not only crystal growth and…”
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Coupling Viedma Ripening with Racemic Crystal Transformations: Mechanism of Deracemization by Xiouras, Christos, Ter Horst, Joop H, Van Gerven, Tom, Stefanidis, Georgios D

“…It has been recently observed that coupling Viedma ripening with a seeded in situ metastable racemic crystal to conglomerate transformation leads to…”
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Applications of ultrasound to chiral crystallization, resolution and deracemization by Xiouras, Christos, Fytopoulos, Antonios, Jordens, Jeroen, Boudouvis, Andreas G., Van Gerven, Tom, Stefanidis, Georgios D.

“…•Ultrasound has been applied to several chiral crystallization processes.•In diastereomeric crystallization, ultrasound can improve both yield and purity.•In…”
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On the Effect of Secondary Nucleation on Deracemization through Temperature Cycles by Cameli, Fabio, ter Horst, Joop H., Steendam, René R. E., Xiouras, Christos, Stefanidis, Georgios D.

“…Herein, the pivotal role of secondary nucleation in a crystallization‐enhanced deracemization process is reported. During this process, complete and rapid…”
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Toward Continuous Deracemization via Racemic Crystal Transformation Monitored by in Situ Raman Spectroscopy by Xiouras, Christos, Belletti, Giuseppe, Venkatramanan, Raghunath, Nordon, Alison, Meekes, Hugo, Vlieg, Elias, Stefanidis, Georgios D, Ter Horst, Joop H

“…In this work, we demonstrate a semibatch solid-state deracemization process for N-(2-chlorobenzylidene)­henylglycine amide­ (NCPA), a complex chiral…”
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Iterative model-based optimal experimental design for mixture-process variable models to predict solubility by Quilló, Gustavo Lunardon, Bhonsale, Satyajeet, Collas, Alain, Xiouras, Christos, Van Impe, Jan F.M.

“…Crystallization process design relies heavily on predictive solubility models. However, their calibration is resource- and labour-intensive, especially for…”
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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase by Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello, Bekkers, Mariette, Cornelissen, Ivo, Packman, Kathryn, Seierstad, Mark, Xiouras, Christos, Bembenek, Scott D., Alexander, Richard, Milligan, Cynthia, Balasubramanian, Sriram, Lebsack, Alec D., Venable, Jennifer D., Philippar, Ulrike, Edwards, James P., Hirst, Gavin

“…Bruton’s tyrosine kinase (BTK) is a Tec family kinase that plays an essential role in B-cell receptor (BCR) signaling as well as Fcγ receptor signaling in…”
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