Search Results - "Xiong, Zhiping Z."

Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase by Maynard, Andrew, Crosby, Renae M., Ellis, Byron, Hamatake, Robert, Hong, Zhi, Johns, Brian A., Kahler, Kirsten M., Koble, Cecilia, Leivers, Anna, Leivers, Martin R., Mathis, Amanda, Peat, Andrew J., Pouliot, Jeffrey J., Roberts, Christopher D., Samano, Vicente, Schmidt, Rachel M., Smith, Gary K., Spaltenstein, Andrew, Stewart, Eugene L., Thommes, Pia, Turner, Elizabeth M., Voitenleitner, Christian, Walker, Jill T., Waitt, Greg, Weatherhead, Jason, Weaver, Kurt, Williams, Shawn, Wright, Lois, Xiong, Zhiping Z., Haigh, David, Shotwell, J. Brad

“…A boronic acid moiety was found to be a critical pharmacophore for enhanced in vitro potency against wild-type hepatitis C replicons and known clinical…”
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Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization by Shotwell, J. Brad, Baskaran, Subramanian, Chong, Pek, Creech, Katrina L, Crosby, Renae M, Dickson, Hamilton, Fang, Jing, Garrido, Dulce, Mathis, Amanda, Maung, Jack, Parks, Derek J, Pouliot, Jeffrey J, Price, Daniel J, Rai, Roopa, Seal, John W, Schmitz, Uli, Tai, Vincent W. F, Thomson, Michael, Xie, Mi, Xiong, Zhiping Z, Peat, Andrew J

“…A series of imidazo­[1,2-a]­pyridines which directly bind to HCV Non-Structural Protein 4B (NS4B) is described. This series demonstrates potent in vitro…”
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