Search Results - "Xiong, Aizhen"

Comprehensive Analysis of Serum and Fecal Bile Acid Profiles and Interaction with Gut Microbiota in Primary Biliary Cholangitis by Chen, Weihua, Wei, Yiran, Xiong, Aizhen, Li, Yanmei, Guan, Huida, Wang, Qixia, Miao, Qi, Bian, Zhaolian, Xiao, Xiao, Lian, Min, Zhang, Jun, Li, Bo, Cao, Qin, Fan, Zhuping, Zhang, Weici, Qiu, Dekai, Fang, Jingyuan, Gershwin, M. Eric, Yang, Li, Tang, Ruqi, Ma, Xiong

“…Accumulation of bile acids (BAs) contributes significantly to the pathogenesis of primary biliary cholangitis (PBC). Here, we sought to systematically…”
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Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM by Xiong, Aizhen, Zhang, Jiwei, Chen, Yan, Zhang, Yi, Yang, Fan

“…BACKGROUNDGlioblastoma (GBM) is the most aggressive type of primary brain tumor and is often resistant to current therapies. Tumor microenvironment-centered…”
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Comparative analysis of toxic components in different medicinal parts of Gynura japonica and its toxicity assessment on mice by Xiong, Aizhen, Shao, Youlin, Fang, Lianxiang, Yang, Xiao, Zhang, Suocai, Zheng, Jian, Ding, Wenxing, Yang, Li, Wang, Zhengtao

“…The roots of Gynura japonica are used as traditional medicine for treating blood stasis or traumatic injury even though hundreds of hepatic sinusoidal…”
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Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction by Xu, Jie, Xiong, Aizhen, Wang, Xunjiang, Yan, Xing, Chen, Yilin, Ye, Xuanling, Wang, Zhengtao, Ding, Lili, Yang, Li

“…Pyrrolizidine alkaloids (PAs) are potent hepatotoxins that can cause liver damage. Hyperoside (Hyp), a natural flavonoid, can be extracted from medicinal…”
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An integrative investigation on the efficacy of Plantaginis semen based on UPLC-QTOF-MS metabolomics approach in hyperlipidemic mice by Sun, Xiaomeng, Lan, Jiping, Tong, Renchao, Zhang, Haoyue, Sun, Shuai, Xiong, Aizhen, Wang, Zhengtao, Yang, Li

“…Plantaginis semen, the dried mature seed of Plantago asiatica L. or Plantago deprdssa Willd., has a prominent effect on the treatment of obesity, type 2…”
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Pyrrolizidine alkaloids: An update on their metabolism and hepatotoxicity mechanism by Xu, Jie, Wang, Weiqian, Yang, Xiao, Xiong, Aizhen, Yang, Li, Wang, Zhengtao

“…Pyrrolizidine alkaloids (PAs) are among the most hepatotoxic natural compounds that are widely distributed throughout the world. Most PAs are metabolically…”
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Characterization of the Principal Constituents of Danning Tablets, a Chinese Formula Consisting of Seven Herbs, by an UPLC-DAD-MS/MS Approach by Zhan, Changsen, Xiong, Aizhen, Shen, Danping, Yang, Li, Wang, Zhengtao

“…Danning Tablets are a traditional Chinese formula showing broad clinical applications in hepatobiliary diseases and containing a diversity of bioactive…”
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Quality Evaluation of Traditional Chinese Medicine Compounds in Xiaoyan Lidan Tablets: Fingerprint and Quantitative Analysis Using UPLC-MS by Yang, Na, Xiong, Aizhen, Wang, Rui, Yang, Li, Wang, Zhengtao

“…XiaoyanLidan tablets (XYLDTs) are traditional Chinese medicines frequently used for syndromes of the liver and gallbladder, cholecystitis and cholangitis. To…”
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Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice by Yang, Xiao, Wang, Hua, Ni, Hong-Min, Xiong, Aizhen, Wang, Zhengtao, Sesaki, Hiromi, Ding, Wen-Xing, Yang, Li

“…Pyrrolizidine alkaloids (PAs) are a group of compounds found in various plants and some of them are widely consumed in the world as herbal medicines and food…”
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Targeted bile acids metabolomics in cholesterol gallbladder polyps and gallstones: From analytical method development towards application to clinical samples by Wei, Jiaojiao, Chen, Tao, Liu, Yamin, Sun, Shuai, Yuan, Zhiqing, Zhang, Yixin, Xiong, Aizhen, Li, Linnan, Wang, Zhengtao, Yang, Li

“…Bile acids (BAs) are synthesized by the liver from cholesterol through several complementary pathways and aberrant cholesterol metabolism plays pivotal roles…”
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Metabolic Biomarkers for Prognostic Prediction of Pre-diabetes: results from a longitudinal cohort study by Zeng, Hailuan, Tong, Renchao, Tong, Wenxin, Yang, Qiaoling, Qiu, Miaoyan, Xiong, Aizhen, Sun, Siming, Ding, Lili, Zhang, Hongli, Yang, Li, Tian, Jingyan

“…To investigate the metabolic biomarkers of predicting the transition from pre-diabetes (pre-DM) to normal glucose regulation (NGR) and diabetes (DM) in a…”
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Blood microRNA Signatures Serve as Potential Diagnostic Biomarkers for Hepatic Sinusoidal Obstruction Syndrome Caused by Gynura japonica Containing Pyrrolizidine Alkaloids by Wang, Xunjiang, Zhang, Wei, Yang, Yongfeng, Chen, Yiran, Zhuge, Yuzheng, Xiong, Aizhen, Yang, Li, Wang, Zhengtao

“…The -induced hepatic sinusoidal obstruction syndrome (HSOS) is closely related to pyrrolizidine alkaloids (PAs), and its prevalence has been increasing…”
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A novel strategy for target profiling analysis of bioactive phenylethanoid glycosides in Plantago medicinal plants using ultra-performance liquid chromatography coupled with tandem quadrupole mass spectrometry by Qi, Meng, Xiong, Aizhen, Geng, Fang, Yang, Li, Wang, Zhengtao

“…Phenylethanoid glycosides are a group of phenolic compounds with diverse biological activities such as hypotensive, diuretic, and hypoglycemic effects. In this…”
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Mass‐spectrometry‐directed analysis and purification of pyrrolizidine alkaloid cis/trans isomers in Gynura japonica by Fang, Lianxiang, Xiong, Aizhen, Yang, Xiao, Cheng, Wenzhi, Yang, Li, Wang, Zhengtao

“…Pyrrolizidine alkaloids are highly hepatotoxic natural chemicals that produce irreversible chronic and acute hepatotoxic effects on human beings. Purification…”
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An application of target profiling analyses in the hepatotoxicity assessment of herbal medicines: comparative characteristic fingerprint and bile acid profiling of Senecio vulgaris L. and Senecio scandens Buch.-Ham by Xiong, Aizhen, Fang, Lianxiang, Yang, Xiao, Yang, Fan, Qi, Meng, Kang, Hong, Yang, Li, Tsim, Karl Wah-Keung, Wang, Zhengtao

“…The toxicity assessment of herbal medicines is important for human health and appropriate utilization of these medicines. However, challenges have to be…”
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Authentication of Senecio scandens and S. vulgaris based on the comprehensive secondary metabolic patterns gained by UPLC–DAD/ESI-MS by Yang, Xuejing, Yang, Li, Xiong, Aizhen, Li, Dingxiang, Wang, Zhengtao

“…A secondary metabolic pattern using ultra-performance liquid chromatography (UPLC)–DAD/ESI-MS was constructed to gain chemical information for authentication…”
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The volatile oil of Nardostachyos Radix et Rhizoma induces endothelial nitric oxide synthase activity in HUVEC cells by Maiwulanjiang, Maitinuer, Bi, Cathy W C, Lee, Pinky S C, Xin, Guizhong, Miernisha, Abudureyimu, Lau, Kei M, Xiong, Aizhen, Li, Ning, Dong, Tina T X, Aisa, Haji A, Tsim, Karl W K

“…Nardostahyos Radix et Rhizoma (NRR; the root and rhizome of Nardostachys jatamansi DC.) is a widely used medicinal herb. Historically, NRR is being used for…”
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The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS by Wang, Changhong, Li, Yan, Gao, Jiangguo, He, Yuqi, Xiong, Aizhen, Yang, Li, Cheng, Xuemei, Ma, Yueming, Wang, Zhengtao

“…Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world’s…”
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A Modified Chinese Herbal Decoction (Kai-Xin-San) Promotes NGF-Induced Neuronal Differentiation in PC12 Cells via Up-Regulating Trk A Signaling by Yan, Lu, Wei, Min, Gong, Amy G, Song, Pingping, Lou, Jianshu, Bi, Cathy W, Xu, Sherry L, Xiong, Aizhen, Dong, Tina T, Tsim, Karl W

“…Kai-Xin-San (KXS), a Chinese herbal decoction, has been applied to medical care of depression for thousands of years. It is composed of two functional…”
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Simultaneous Quantification of Four Indole Alkaloids in Catharanthus roseus Cell Line C20hi by UPLC-MS by HE, Lihong, YANG, Li, XIONG, Aizhen, ZHAO, Shujuan, WANG, Zhengtao, HU, Zhibi

“…An ultra-performance liquid chromatography/mass spectrometry method to simultaneously quantify vindoline, catharanthine, serpentine and ajmalicine in…”
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