Search Results - "Xing, Zenan"
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Dynamic control of plant water use using designed ABA receptor agonists
Published in Science (American Association for the Advancement of Science) (25-10-2019)“…Drought causes crop losses worldwide, and its impact is expected to increase as the world warms. This has motivated the development of small-molecule tools for…”
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The fronds tonoplast quantitative proteomic analysis in arsenic hyperaccumulator Pteris vittata L
Published in Journal of proteomics (13-06-2014)“…Pteris vittata, the first known arsenic hyperaccumulating plant, can accumulate very high concentration arsenic in its aboveground tissues, while low in roots…”
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Functional genomic screening in Komagataella phaffii enabled by high-activity CRISPR-Cas9 library
Published in Metabolic engineering (01-09-2024)“…CRISPR-based high-throughput genome-wide loss-of-function screens are a valuable approach to functional genetics and strain engineering. The yeast Komagataella…”
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An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity
Published in Nature chemical biology (01-01-2024)“…Plants sense abscisic acid (ABA) using chemical-induced dimerization (CID) modules, including the receptor PYR1 and HAB1, a phosphatase inhibited by…”
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Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo
Published in Proceedings of the National Academy of Sciences - PNAS (21-09-2021)“…Abscisic acid (ABA) is a key plant hormone that mediates both plant biotic and abiotic stress responses and many other developmental processes. ABA receptor…”
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Rationalizing Diverse Binding Mechanisms to the Same Protein Fold: Insights for Ligand Recognition and Biosensor Design
Published in ACS chemical biology (16-08-2024)“…The engineering of novel protein–ligand binding interactions, particularly for complex drug-like molecules, is an unsolved problem, which could enable many…”
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Functional analysis of synthetic DELLA domain peptides and bioactive gibberellin assay using surface plasmon resonance technology
Published in Talanta (Oxford) (01-11-2015)“…DELLA proteins and phytohormone gibberellin act together to control convergence point of plant development. A gibberellin-bound nuclear receptor that interacts…”
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