A Review on Nanomaterial-based Strategies for Manipulating Tumor Microenvironment to Enhance Chemodynamic Therapy

A Review on Nanomaterial-based Strategies for Manipulating Tumor Microenvironment to Enhance Chemodynamic Therapy

Cancer is a leading cause of death worldwide, and a series of strategies has been reported for tumor-specific therapy. Currently, chemodynamic therapy (CDT) has become a research hotspot for antitumor treatment due to its advantages of high specificity, endogenous stimulation, and high biosafety. Ho...

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Bibliographic Details
Published in:Chemical research in Chinese universities Vol. 40; no. 2; pp. 202 - 212
Main Authors: Cao, Mengyu, Xing, Xiner, Shen, Xiaotong, Ouyang, Jin, Na, Na
Format: Journal Article
Language:English
Published: Changchun Jilin University and The Editorial Department of Chemical Research in Chinese Universities 01-04-2024
Springer Nature B.V
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Glutathione
Hydrogen peroxide
Hypoxia
Inorganic Chemistry
Nanomaterials
Organic Chemistry
Physical Chemistry
Review
Therapy
Chemodynamic therapy
Tumor microenvironment
Manipulating strategy
Nanomaterial
Fenton/Fenton-like reaction
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Summary:Cancer is a leading cause of death worldwide, and a series of strategies has been reported for tumor-specific therapy. Currently, chemodynamic therapy (CDT) has become a research hotspot for antitumor treatment due to its advantages of high specificity, endogenous stimulation, and high biosafety. However, the therapeutic effects of CDT are normally limited in the complex tumor microenvironment (TME), such as insufficient acidity, tumor hypoxia, low hydrogen peroxide (H 2 O 2 ), and high glutathione (GSH). Consequently, different kinds of multifunctional nanomaterials have been designed to manipulate TME conditions, which provided more opportunities to improve the efficiency of CDT. This review focuses on nanomaterial-based strategies for enhancing CDT through manipulating TME. Upon CDT enhancements, this review would provide a reference for the future development of efficient CDT nanomaterials.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-024-3267-6