Search Results - "Xing, Shuaishuai"

Medicinal Prospects of Targeting Tyrosinase: A Feature Review by Wang, Yuanyuan, Xiong, Baichen, Xing, Shuaishuai, Chen, Ying, Liao, Qinghong, Mo, Jun, Chen, Yao, Li, Qi, Sun, Haopeng

“…Tyrosinase is a bifunctional polyphenol oxidase (PPO), catalyzing two oxidative reactions: monophenols to o-quinones (monophenolase activity) and o-diphenols…”
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Strategies for Structural Modification of Small Molecules to Improve Blood–Brain Barrier Penetration: A Recent Perspective by Xiong, Baichen, Wang, Yuanyuan, Chen, Ying, Xing, Shuaishuai, Liao, Qinghong, Chen, Yao, Li, Qi, Li, Wei, Sun, Haopeng

“…In the development of central nervous system (CNS) drugs, the blood–brain barrier (BBB) restricts many drugs from entering the brain to exert therapeutic…”
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Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism by Xing, Shuaishuai, Li, Qi, Xiong, Baichen, Chen, Yao, Feng, Feng, Liu, Wenyuan, Sun, Haopeng

“…Structural information of butyrylcholinesterase (BChE) and its variants associated with several diseases are discussed here. Pure human BChE has been proved…”
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Triazoles in Medicinal Chemistry: Physicochemical Properties, Bioisosterism, and Application by Guan, Qianwen, Xing, Shuaishuai, Wang, Lei, Zhu, Jiawei, Guo, Can, Xu, Chunlei, Zhao, Qun, Wu, Yulan, Chen, Yao, Sun, Haopeng

“…Triazole demonstrates distinctive physicochemical properties, characterized by weak basicity, various dipole moments, and significant dual hydrogen bond…”
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Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection by Li, Qi, Chen, Ying, Xing, Shuaishuai, Liao, Qinghong, Xiong, Baichen, Wang, Yuanyuan, Lu, Weixuan, He, Siyu, Feng, Feng, Liu, Wenyuan, Chen, Yao, Sun, Haopeng

“…Butyrylcholinesterase (BChE) has been considered as a potential therapeutic target for Alzheimer’s disease (AD) because of its compensation capacity to…”
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Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor by Li, Qi, Xing, Shuaishuai, Chen, Ying, Liao, Qinghong, Xiong, Baichen, He, Siyu, Lu, Weixuan, Liu, Yang, Yang, Hongyu, Li, Qihang, Feng, Feng, Liu, Wenyuan, Chen, Yao, Sun, Haopeng

“…To discover novel BChE inhibitors, a hierarchical virtual screening protocol followed by biochemical evaluation was applied. The most potent compound 8012-9656…”
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STING, a promising target for small molecular immune modulator: A review by Liu, Yijun, Lu, Xin, Qin, Nan, Qiao, Yuting, Xing, Shuaishuai, Liu, Wenyuan, Feng, Feng, Liu, Zongliang, Sun, Haopeng

“…Stimulator of interferon genes (STING) plays a crucial role in human innate immune system, which is gradually concerned following the emerging immunotherapy…”
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p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators by Chen, Ying, Li, Qi, Li, Qihang, Xing, Shuaishuai, Liu, Yang, Liu, Yijun, Chen, Yao, Liu, Wenyuan, Feng, Feng, Sun, Haopeng

“…p62/SQSTM1, encoded by gene SQSTM1, is widely known as an adaptor protein of selective autophagy to promote aggregate-prone proteins for degradation. It is…”
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NRF2 inhibitors: Recent progress, future design and therapeutic potential by Lv, Bingbing, Xing, Shuaishuai, Wang, Zhiqiang, Zhang, Ao, Wang, Qinjie, Bian, Yaoyao, Pei, Yuqiong, Sun, Haopeng, Chen, Yao

“…Nuclear factor erythroid 2-related factor 2 (NRF2) is a crucial transcription factor involved in oxidative stress response, which controls the expression of…”
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Review of triazole scaffolds for treatment and diagnosis of Alzheimer's disease by Li, Qi, Qi, Shulei, Liang, Jinxin, Tian, Yuqing, He, Siyu, Liao, Qinghong, Xing, Shuaishuai, Han, Lingfei, Chen, Xuehong

“…Triazole scaffolds, a series of 5-membered heterocycles, are well known for their high efficacy, low toxicity, and superior pharmacokinetics. Alzheimer's…”
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The Development and Design Strategy of Leucine-Rich Repeat Kinase 2 Inhibitors: Promising Therapeutic Agents for Parkinson’s Disease by Tang, Xu, Xing, Shuaishuai, Ma, Mingkang, Xu, Ziwei, Guan, Qianwen, Chen, Yuting, Feng, Feng, Liu, Wenyuan, Chen, Tingkai, Chen, Yao, Sun, Haopeng

“…Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting millions of people worldwide. Mutations in the gene encoding leucine-rich repeat…”
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Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases by Li, Qi, Xing, Shuaishuai, Chen, Ying, Liao, Qinghong, Li, Qihang, Liu, Yang, He, Siyu, Feng, Feng, Chen, Yao, Zhang, Jie, Liu, Wenyuan, Guo, Qinglong, Sun, Yuan, Sun, Haopeng

“…Neurodegenerative diseases are a variety of debilitating and fatal disorder in central nervous system (CNS). Besides targeting neuronal activity by influencing…”
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Optimizing drug-like properties of selective butyrylcholinesterase inhibitors for cognitive improvement: Enhancing aqueous solubility by disrupting molecular plane by Xing, Shuaishuai, Tang, Xu, wang, Leyan, Wang, Jun, Lv, Bingbing, Wang, Xiaolong, Guo, Can, Zhao, Ye, Feng, Feng, Liu, Wenyuan, Chen, Yao, Sun, Haopeng

“…Most recently, worldwide interest in butyrylcholinesterase (BChE) as a potential target for treating Alzheimer's disease (AD) has increased. In this study, the…”
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A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement by Li, Qi, Xiong, Baichen, Wang, Yuanyuan, Lyu, Weiping, Xing, Shuaishuai, Chen, Ying, Liao, Qinghong, He, Siyu, Feng, Feng, Liu, Wenyuan, Chen, Yao, Sun, Haopeng

“…Butyrylcholinesterase (BChE) has been more and more attractive for treating neurodegenerative diseases, especially Alzheimer's disease (AD). In this study, we…”
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Discovery of Resorcinol-Based Polycyclic Structures as Tyrosinase Inhibitors for Treatment of Parkinson’s Disease by Li, Qi, Mo, Jun, Xiong, Baichen, Liao, Qinghong, Chen, Ying, Wang, Yuanyuan, Xing, Shuaishuai, He, Siyu, Lyu, Weiping, Zhang, Ning, Sun, Haopeng

“…Tyrosinase is involved in the synthesis of neuromelanin in the substantia nigra, which is closely correlated with the pathogenesis of Parkinson’s disease…”
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Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment by He, Siyu, Chu, Xianglin, Wu, Yujia, Jiang, Jiheng, Fang, Pengfei, Chen, Yuting, Liu, Yang, Qiu, Zhixia, Xiao, Yibei, Li, Zhiyu, Pan, Di, Zhang, Qian, Xie, Huanfang, Xing, Shuaishuai, Feng, Feng, Liu, Wenyuan, Guo, Qinglong, Zhao, Li, Yang, Peng, Sun, Haopeng

“…Aldo-keto reductase 1C3 (AKR1C3) is correlated with tumor development and chemotherapy resistance. The catalytic activity of the enzyme has been recognized as…”
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Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease by Chen, Ying, Zhang, Weiting, Li, Qi, Xie, Huanfang, Xing, Shuaishuai, Lu, Xin, Lyu, Weiping, Xiong, Baichen, Wang, Yuanyuan, Qu, Wei, Liu, Wenyuan, Chi, Heng, Zhang, Xiaolong, Feng, Feng, Sun, Haopeng

“…Butyrylcholinesterase (BChE) has attracted wide interest as a promising target in Alzheimer's disease (AD) investigation. BChE is considered to play a…”
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Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance by He, Siyu, Liu, Yang, Chu, Xianglin, Li, Qi, Lyu, Weiping, Liu, Yijun, Xing, Shuaishuai, Feng, Feng, Liu, Wenyuan, Guo, Qinglong, Zhao, Li, Sun, Haopeng

“…As a crucial target which is overexpressed in a variety of cancers, aldo-keto reductase 1C3 (AKR1C3) confers chemotherapeutic resistance to many clinical…”
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Synthesis and bio-evaluation of a novel selective butyrylcholinesterase inhibitor discovered through structure-based virtual screening by Xing, Shuaishuai, Chen, Ying, Xiong, Baichen, Lu, Weixuan, Li, Qi, Wang, Yuanyuan, Jiao, Mengxia, Feng, Feng, Chen, Yao, Liu, Wenyuan, Sun, Haopeng

“…In recent years, butyrylcholinesterase (BChE) has gradually gained worldwide interests as a novel target for treating Alzheimer's disease (AD). Here, two…”
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